A wound dressing material comprising: a wound dressing carrier, N-acetyl cysteine or a salt or derivative thereof, and a stabilized ascorbate. Suitably, the stabilized ascorbate comprises an ascorbate-2-polyphosphate. Also provided are wound dressings comprising the materials, methods of treatment with the materials, and methods of making the materials.

Dermal filler hydrogel compositions, methods of making them, and methods of using them to treat soft tissue conditions, such as wrinkles, are provided. The compositions contain a crosslinked hyaluronic acid-based polymer and one or more additional ingredients, and are stable to sterilization by heat and/or pressure treatment. The additional ingredients include vasoconstrictive agents, antioxidant agents, such as a ascorbic acid agents, and/or anesthetic agents.

The present invention relates to a biopolymer-based hydrogel as a functional biomaterial produced by crosslinking in the presence of a photopolymerization initiator. The hydrogel of the present invention is elastic so as to be adapted to various shapes in both in vivo and in vitro applications. It is biocompatible, achieving maximum effects on wound healing as wound dressing and tissue adhesion preventing material. The present invention also relates to a method for producing the biocompatible hydrogel.

A new MANUFACTURING PROCESS FOR AN ADHERENT SILICONE HEALING TAPE/PAD/DRESSING OF SPECIFIC SHAPES, for application in the medical area aiming to provide greater results in the healing of keloid scars as a fibroproliferative disorder, since the following specific properties make silicone useful for dressings: safe, low thermal conductivity, low chemical reactivity, low toxicity and rare adverse reactions, as the silicone cannot be absorbed into the body, repels the water and creates a watertight seal, it does not support microbial growth, has high gas permeability, and is adherent to dry skin.

The instant disclosure is directed to devices and methods for facilitating bone growth. In one embodiment, a device may include a porous flexible tube comprising an electrospun fiber. The porous flexible tube may also comprise a closed end. The device may further comprise a filler material at least partially encased by the porous flexible tube. A method of manufacturing such a device may comprise electrospinning a polymer solution onto an end of a cylindrical mandrel to form the porous flexible tube, and removing the porous flexible tube from the end of the cylindrical mandrel. A method of facilitating bone growth may comprise obtaining such a device, and implanting the porous flexible tube into a subject's bone defect.

Provided herein are therapeutic acrylate compounds useful as medical adhesives, comprising a therapeutic agent covalently linked to a methacrylate or cyanoacrylate moiety. Adhesive compositions and kits, such as liquid sutures and bone cement also are provided along with uses for the compositions.

The invention concerns an intraocular lens implant for placement into an intracapsular space of a lens capsule of an eye and a composition, kit and methods related to the lens implant. The lens implant is designed for a placement into a posterior portion of the intracapsular space after removal of a native lens body and has a convex posterior surface. The lens implant is formed of one part and is manufactured from a suitable transparent non-structural cellular material. This keeps an anterior portion of the intracapsular space free of the implant which is dimensioned to comprise at most 40% of a volume of the native lens body.

Liquid embolic preparations and medical treatment methods of using those preparations are described. In some embodiments, the preparations or solutions can transition from a liquid to a solid for use in the embolization. The preparations can include biocompatible polymers with covalently bound radioactive iodine isotopes.

This invention relates generally to methods of inhibiting arterial rupture and the progression of an arterial aneurysm. In particular, the methods comprise applying a photosensitizer to an arterial wall and irradiating the arterial wall with photo-activating radiation to initiate crosslinking in the arterial wall and inhibit arterial rupture and the progression of an arterial aneurysm.

Balloon catheters, methods for preparing balloon catheters, and uses of balloon catheters are disclosed. The balloon catheter includes an elongate member, an expandable balloon, and a coating layer overlying an exterior surface of the expandable balloon. The coating layer includes a total drug load of a hydrophobic therapeutic agent and a combination of additives including a first additive and a second additive. The hydrophobic therapeutic agent is paclitaxel, rapamycin, or paclitaxel and rapamycin. The first additive is a surfactant. The second additive is a chemical compound having one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide, or ester groups.