Featured are a biocompatible, injectable, self-setting, cohesive, bone-bonding and remodeling calcium phosphate composite material and its use in methods of repairing defective bone, e.g., in vertebroplasty augmentation and kyphoplasty.

This disclosure relates to devices, method, and material compositions. Specifically, the present invention related to a delivery device to deliver a material composition that seals a tract, for example during a percutaneous intervention.

A cartridge loader is provided. The cartridge loader can include a loader body, a top loader bay slidingly engaged to the loader body, and a bottom loader bay slidingly engaged to the loader body. The cartridge loader can further include a cleaning assembly coupled to the loader body. The cartridge loader can be manipulated from a first configuration to a second configuration, such that when in the first configuration, the cartridge loader can receive a cartridge shield containing a cartridge therein, and when in the second configuration, if no cartridge shield is received, the cleaning assembly is configured to disinfect the cartridge loader.

In some aspects, the present disclosure pertains to radiopaque crosslinked hydrogel compositions that comprise a crosslinked reaction product of (a) a polyamino iodinated compound and (b) a reactive polymer that comprises a plurality of reactive groups that are reactive with the amino groups of the polyamino iodinated compound. In other aspects, the present disclosure pertains to systems for forming a hydrogel composition that comprise (a) a polyamino iodinated compound and (b) a reactive polymer that comprises a plurality of reactive groups that are reactive with the amino groups of the polyamino iodinated compound. In further aspects, the present disclosure pertains to methods of treatment using such systems.

Described herein are fluid complex coacervates that produce solid adhesives in situ. Oppositely charged polyelectrolytes were designed to form fluid adhesive complex coacervates at ionic strengths higher than the ionic strength of the application site, but an insoluble adhesive solid or gel at the application site. When the fluid, high ionic strength adhesive complex coacervates are introduced into the lower ionic strength application site, the fluid complex coacervate is converted to a an adhesive solid or gel as the salt concentration in the complex coacervate equilibrates to the application site salt concentration. In one embodiment, the fluid complex coacervates are designed to solidify in situ at physiological ionic strength and have numerous medical applications. In other aspects, the fluid complex coacervates can be used in aqueous environment for non-medical applications.

In some embodiments, the present invention provides compositions that comprise: (1) a biodegradable polymer matrix; and (2) at least one biodegradable reinforcing particle that is dispersed in the matrix. In some embodiments, the biodegradable reinforcing particle is selected from the group consisting of porous oxide particles and porous semiconductor particles. In additional embodiments, the compositions of the present invention further comprise a (3) porogen particle that is also dispersed in the matrix. In further embodiments, the compositions of the present invention are also associated with one or more active agents. In various embodiments, the active agents are associated with the biodegradable polymer matrix, the biodegradable reinforcing particle, and/or the porogen particle. In various embodiments, the compositions of the present invention may be utilized as scaffolds, such as scaffolds for treating bone defects. Further embodiments of the present invention pertain to methods of making the compositions of the present invention.

Methods and apparatuses, including computer program products, are described for secure validation of financial transactions. A server computing device registers a mobile device to receive notification messages from the server computing device. The server computing device transmits a notification message via a first communication channel to a notification agent executing on the registered mobile device, where the message identifies activity associated with a financial account of a user of the registered mobile device. The server computing device receives a response to the notification message via a second communication channel from an application executing on the registered mobile device, if the notification message requires a response. The server computing device stores the response in a database coupled to the server computing device, and determines whether to (i) allow, (ii) deny, or (iii) deny and report as fraud the identified activity based upon the response.

The present invention relates to a paste-powder binary bone cement used in arthroplasty or vertebroplasty, and, more particularly, to a paste-powder binary bone cement which can be directly used at a site to be treated without additionally waiting it to the site by dissolving predetermined chemically-unreactive powdered compositions in a liquid monomer to form paste having high viscosity and then mixing other powdered components with the paste in a minimum amount of air, and to an apparatus for injecting the same.

Bioactive implant for myocardial regeneration and ventricular chamber support including an elastomeric microporous membrane. The elastomeric microporous membrane being at least one non-degradable polymer and at least one partially degradable polymer. The non-degradable polymer is selected from polyethylacrylate and polyethylacrylate copolymerized with a hydroxyethylacrylate comonomer. The partially degradable polymer is selected from caprolactone 2-(methacryloyloxy)ethyl ester and caprolactone 2-(methacryloyloxy)ethyl ester copolymerized with ethylacrylate. The elastomeric microporous membrane further includes a nanofiber hydrogel, and cells. The bioactive implant, having one or two helical loops, contributes to the restoration of the heart conical shape. Cardiac wrapping by ventricular support bioprostheses of the present invention, having reinforcement bands spatially distributed as helicoids, recovers the sequential contraction of the myocardium resulting in the successive shortening and lengthening of the ventricles, therefore improving the ejection (systolic function) and suction of blood (diastolic function).

This disclosure features elongated prosthetic devices that can be used to repair, e.g., resurface or occlude, a defect of a semicircular canal, e.g., a superior semicircular canal dehiscence, as wellmethods of making and using these devices. For example, the devices can be made using three-dimensional (3D) printing.