Transcervical access systems for providing transcervical movement of fluids are described. The transcervical access systems are effective for transferring a broad range of fluids, including the delivery of hydrogel precursors, saline, and imaging fluids, to the uterine cavity. The transcervical access systems are also effective for removing fluids from the uterine cavity, such as residual bodily fluids, residual fluids from a procedure, or tissue. The transcervical access systems described include flow limiters, such as egress limiters and/or cervical plugs. Methods of use of the transcervical access systems are also described. Methods include using the transcervical access systems to transcervical access the uterine cavity and install hydrogel. The transcervical access systems and associated methods can be useful for providing degradable hydrogel in the uterine cavity, including the cervical canal, for the prevention of adhesions following intrauterine procedures.

A preparation of nano silver/dual modified chitosan antibacterial hydrogel dressing with discoloration effect for wound infection judgement and hydrogel dressing prepared by the same provided. The preparation includes the following: carrying out quaternization water-soluble modification on high molecular weight chitosan, and carrying out catecholamination water-soluble modification to prepare dual water-soluble modified chitosan; reducing silver nitrate by using the dual water-soluble modified chitosan to prepare a nano silver/dual water-soluble modified chitosan solution; adding the dual water-soluble modified chitosan, the nano silver/dual water-soluble modified chitosan, curcumin, zwitterion, acrylamide, a cross-linking agent and an initiator into deionized water in sequence, mixing and stirring uniformly, centrifugal de-foaming and casting, to prepare a nano silver/dual modified chitosan antibacterial color-changing hydrogel dressing by one-pot in-situ radical polymerization. The nano silver/dual modified chitosan antibacterial hydrogel dressing exhibits great potential for application in fields such as intelligent indicative wound repair hydrogel dressing and the like.

The present invention is directed to an adherent resorbable matrix for use in surgical applications. The adherent resorbable matrix includes a biocompatible adherent material including chitosan.

The present invention relates to a material for preparing an intraocular lens. In particular, it relates to an ophthalmic medical material suitable for manufacture of micro-incision intraocular lens, having suitable water content and a suitable refractive index.

Ink formulations comprising bioactive particles, methods of printing the inks into three-dimensional (3D) structures, and methods of making the inks are provided. Also provided are objects, such as tissue growth scaffolds and artificial bone, made from the inks, methods of forming the objects using 3D printing techniques, and method for growing tissue on the tissue growth scaffolds. The inks comprise a plurality of bioactive ceramic particles, a biocompatible polymer binder, optionally at least one bioactive factor, and a solvent.

Disclosed are adjustable accommodating intraocular lenses and methods of adjusting accommodating intraocular lenses post-operatively. In one embodiment, an adjustable accommodating intraocular lens comprises an optic portion and a peripheral portion. At least one of the optic portion and the peripheral portion can be made in part of a composite material comprising an energy absorbing constituent and a plurality of expandable components. At least one of a base power and a cylindricity of the optic portion can be configured to change in response to an external energy directed at the composite material.

The present disclosure relates to the development of hydrogels with extreme stiffness and high-strength. In particular, an hydrogel comprising poly(2-hydroxyethyl methacrylate) and graphene material with a specific oxidation degree. The hydrogels of the present disclosure may be used in medicine, veterinary or cosmetic, namely as scaffold, cartilage, intervertebral disc and blood contact device such as: catheters, vascular grafts, heart valves, stents, artificial kidneys, artificial lungs, ventricular assist devices or drug delivery system. Uses in other areas can be envisaged, like in soft robotics, packaging, sealing and sensors.

A gel is to be disclosed, in particular for use in a wound treatment composition, with which a particularly high storage stability and long-term stability can be achieved with high microbiocidal activity. For this purpose, the gel according to the invention comprises an inorganic silicate as thickener and an electrochemically activated starting saline solution which has a free chlorine content of more than 300 mg/l. In addition, a colored gel having the properties described above can be obtained by adding suitable pigments.

The invention relates to a functional wound dressing being able to detect and indicate the state of the wound, in particular with regard to infections for example caused by toxins produced by bacteria such Staphylococcus aureus and Pseudomonas aeruginosa. The present wound dressing can be used in moist wound healing and contains a substance being able to absorb wound exudate from the wound and to provide moisture to the wound.

An embodiment includes a system comprising a thermoset polyurethane shape memory polymer (SMP) foam that includes at least one antimicrobial agent. The antimicrobial agent may include at least one phenolic acid that is a pendent group chemically bonded to a polyurethane polymer chain of the SMP foam. Other embodiments are described herein.