There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.

Various embodiments disclosed relate to a lubricant. The lubricant includes a first non-amphiphilic triglyceride. The lubricant further includes a second non-amphiphilic triglyceride. The second non-amphiphilic triglyceride is different from the first non-amphiphilic triglyceride. The lubricant further includes a non-amphiphilic glycol ester.

Lubricious coatings for medical devices and their uses are described.

This disclosure is directed to a resilient interpositional arthroplasty implant. Such implants function to pad cartilage defects, cushion, and replace or restore the articular surface, which may preserve joint integrity, reduce pain and improve function. The implant may endure variable joint compressive and shear forces and cyclic loads. The implant may repair, reconstruct, and regenerate joint anatomy, and thereby improve upon joint replacement alternatives. The walls of this invention may capture, distribute and hold living cells until aggregation and hyaline cartilage regrowth occurs. The implant may be deployed into debrided joint spaces, molding and conforming to surrounding structures with sufficient stability so as to enable immediate limb use after outpatient surgery. Appendages of the implant may repair or reconstruct tendons or ligaments, and menisci by interpositional inflatable or compliant polymer arthroplasties that promote anatomic joint motion.

A method of using a film-forming material for pre-treating an area of skin to reduce friction-related skin irritation, resulting in a reduced risk of acquiring skin chafing and/or blisters, such as may be caused by the wearing of shoes that abrade skin, and particularly including heels, said method comprising the steps of providing a dispensing device containing a film-forming material that includes a friction-reducing and/or friction-blocking element, and applying such film-forming material to an area of skin to reduce friction and thereby reduce the risk of acquiring chafing and/or a blister.

Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.

Methods for viscosupplementation in a joint or surgical site of a human or animal subject are disclosed along with unique materials for achieving such beneficial outcomes. The methods generally comprise introducing into the joint or surgical site a plurality of porous viscoelastic solid hydrogel microparticles having a size of greater than about 30 pm, and substantially free of any cells, tissue, or therapeutic compounds. Kits for viscosupplementation in a joint or surgical site of a human or animal subject are also disclosed. The kits comprise the plurality of porous viscoelastic solid hydrogel microparticles having a size of greater than about 30 pm, and substantially free of any cells, tissue, or therapeutic compounds, and instructions for administering the same.

This disclosure is directed to a resilient interpositional arthroplasty implant. Such implants function to pad cartilage defects, cushion, and replace or restore the articular surface, which may preserve joint integrity, reduce pain and improve function. The implant may endure variable joint compressive and shear forces and cyclic loads. The implant may repair, reconstruct, and regenerate joint anatomy, and thereby improve upon joint replacement alternatives. The walls of this invention may capture, distribute and hold living cells until aggregation and hyaline cartilage regrowth occurs. The implant may be deployed into debrided joint spaces, molding and conforming to surrounding structures with sufficient stability so as to enable immediate limb use after outpatient surgery. Appendages of the implant may repair or reconstruct tendons or ligaments, and menisci by interpositional inflatable or compliant polymer arthroplasties that promote anatomic joint motion.

This invention relates to comfortable ophthalmic devices and methods of producing such devices.

This invention relates to comfortable ophthalmic devices and methods of producing such devices.