There is described inter alia a device having a surface comprising a layered coating wherein the outer coating layer comprises a plurality of cationic hyperbranched polymer molecules characterized by having (i) a core moiety of molecular weight 14-1,000 Da (ii) a total molecular weight of 1,500 to 1,000,000 Da (iii) a ratio of total molecular weight to core moiety molecular weight of at least 80:1 and (iv) functional end groups, whereby one or more of said functional end groups have an anti-coagulant entity covalently attached thereto.

This disclosure is directed to a resilient interpositional arthroplasty implant for application into a knee joint to pad cartilage defects, cushion a joint, and replace or restore the articular surface, which may preserve joint integrity, reduce pain and improve function. The implant may endure variable joint compressive and shear forces and cyclic loads. The implant may repair, reconstruct, and regenerate joint anatomy, and thereby improve upon joint replacement alternatives. Rather than using periosteal harvesting for cell containment in joint resurfacing, the walls of this invention may capture, distribute and hold living cells until aggregation and hyaline cartilage regrowth occurs. The implant may be deployed into debrided joint spaces, molding and conforming to surrounding structures with sufficient stability to avoid extrusion or dislocation. Appendages of the implant may repair or reconstruct tendons or ligaments, and an interior of the implant that is inflatable may accommodate motions which mimic or approximate normal joint motion.

A sanitary device for insertion into a body cavity having a perforated casing in which a medicant is located within a distal portion of the casing and a semi-rigid absorbent material is located within a proximal portion of the casing. A plunger extends into the casing from the proximal portion and is movable to force the semi-rigid absorbent material into contact with the medicant which forces the medicant out of the distal portion of the casing. Unwanted body fluids can drain into the proximal portion and are absorbed by the semi-rigid absorbent material.

A second embodiment of the invention includes an applicator for inserting a body insert into the body cavity. The body insert includes a semi-rigid absorbent material surrounded by a thin sheet of a lubricating material such as Telfa. The body insert may also include a medicant in the form of a gel material.

Provided herein is a method for storing an emulsion-adjuvanted vaccine in a medical injection device having a lubricant coating, said method including the steps of: (a) providing a medical injection device having a barrel having an inner surface; (b) forming a silicone oil layer on at least a part of the inner surface of the barrel that is intended to be in contact with the vaccine; (c) carrying out an oxidizing plasma treatment of the layer so as to crosslink at least part of the silicone oil layer and form a lubricant coating; and (d) filling the barrel with the emulsion-adjuvanted vaccine. The invention also relates to a medical injection device obtained directly from this method and to the use of plasma-treated silicone oil as a lubricant coating.

This disclosure is directed to a resilient interpositional arthroplasty implant for application into a knee joint to pad cartilage defects, cushion a joint, and replace or restore the articular surface, which may preserve joint integrity, reduce pain and improve function. The implant may endure variable joint compressive and shear forces and cyclic loads. The implant may repair, reconstruct, and regenerate joint anatomy, and thereby improve upon joint replacement alternatives. Rather than using periosteal harvesting for cell containment in joint resurfacing, the walls of this invention may capture, distribute and hold living cells until aggregation and hyaline cartilage regrowth occurs. The implant may be deployed into debrided joint spaces, molding and conforming to surrounding structures with sufficient stability to avoid extrusion or dislocation. Appendages of the implant may repair or reconstruct tendons or ligaments, and an interior of the implant that is inflatable may accommodate motions which mimic or approximate normal joint motion.

A sanitary device for insertion into a body cavity having a perforated casing in which a medicant is located within a distal portion of the casing and a semi-rigid absorbent material is located within a proximal portion of the casing. A plunger extends into the casing from the proximal portion and is movable to force the semi-rigid absorbent material into contact with the medicant which forces the medicant out of the distal portion of the casing. Unwanted body fluids can drain into the proximal portion and are absorbed by the semi-rigid absorbent material. A second embodiment of the invention includes an applicator for inserting a body insert into the body cavity. The body insert includes a semi-rigid absorbent material surrounded by a thin sheet of a lubricating material such as Telfa. The body insert may also include a medicant.

Methods are provided for surface-modifying a rubber vulcanizate or a thermoplastic elastomer. The methods allow these objects to have a lubricating surface layer chemically fixed thereon and thus exhibit excellent lubricity and excellent lubricant durability, instead of having a resin coating which has drawbacks such as reduction in lubricity due to e.g. separation or peeling of the coating during movement within a vessel or tract. Further, the methods have good productivity and good economic efficiency. Included is a method for surface-modifying an object made of a rubber vulcanizate or a thermoplastic elastomer, the method including: step 1 of forming polymerization initiation points on a surface of the object; and step 2 of radically polymerizing a monomer starting from the initiation points by irradiation with UV of 300-400 nm to grow polymer chains on the surface so that a modification layer of 70-1200 nm thickness is formed on the surface.

The present invention relates to a device for assisting childbirth and/or preventing obstructed labour, a method of making the device, and a method of assisting childbirth and/or preventing obstructed labour. The invention also extends to use of a hydrogel to assist childbirth and/or prevent obstructed labour.

A catheter system for draining a fluid from a bladder. The system includes a catheter combined with an amount of chlorine dioxide adapted to reduce infection in catheter associate urinary tract infections. The chlorine dioxide is adapted for use with at least one of a hydrophilic coating on an outer surface of the catheter, a wetting fluid that interacts with the hydrophilic coating and a lubricant in contact with the outer surface of the catheter.

According to various embodiments, a glove is provided with improved hydration characteristics and low dermatitis potential. The glove comprises a substrate and a polymer system that coats a surface of the substrate. The polymer system comprises: a polyol, a botanical extract, an emollient agent, a silicone copolymer dispersion, a lubricant, and a surfactant. The substrate may be free of sulphur and accelerators. An example formulation of the polymer system may comprise glycerol, Aloe vera, a carnauba wax dispersion, dimethicone, a polyalkylene glycol (PAG), and polyoxyethylene (20) sorbitan monooleate. The polymer system may be applied to the\surface of the substrate by dipping the surface into a water-based dispersion of the polymer system, or spraying the water-based dispersion onto the interior surface. The polymer system may be blended into water at a total solids content of 0.8% to 1.2% w/w to form the water-based dispersion.