The present invention relates to the unexpected discovery of novel hydrogel formulations that allow for the encapsulation and delivery of living cells and/or drugs to a subject in need thereof. In certain embodiments, the hydrogel compositions of the invention comprise bound bioactive molecules that promote long-term cell viability and allows for the development of vasculature. The invention further provides methods of delivering viable cells and/or drugs to a subject comprising administering the compositions of the invention to the subject in need thereof.

The present invention relates to the use of scaffolds to enhance the viability of cells implanted in the integumentary system such that the cell may release an agent. The scaffold is capable of protecting the cell, as well as allowing for adequate nutrient delivery at the implant site through vascularisation in and around the scaffold.

This invention relates to anti-microbial active particles, compositions and uses thereof for inhibiting bacterial growth on surfaces or devices. This invention further discloses methods of making such anti-microbial active particles.

The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human insulin in a mammal in response to glucose stimulation.

Encapsulation devices, systems and methods are provided. In some embodiments, encapsulation devices for housing cells and providing various therapeutic benefits to a patient or host are provided. Encapsulation devices are provided that include a matrix or scaffold within a cell-receiving area or void, and methods of forming and preparing such a matrix are disclosed. Encapsulation devices that include channels are further provided, and the channels of the present disclosure are operable to convey fluid to internal areas of devices without restricting vascularization.

Hydrogels and hydrogel prepolymer compositions are described which include micronized eggshell particles. The hydrogels have outstanding tunability in physical, chemical, and biological properties, and have favorable properties for biomedical applications. They enable tissue formation and regeneration and are suitable for applications involving mineralized tissues such as bone, cartilage, tooth, and tendon, as well as non-mineralized tissues.

The present disclosure related to a method of using high frequency sound waves directed toward an acoustically active particle. The high frequency sound waves may be configured to enlarge the acoustically active particle and oscillate the acoustically active particle, thereby facilitating extravasation of an agent to a tissue compartment of a region of interest.

A gel is to be disclosed, in particular for use in a wound treatment composition, with which a particularly high storage stability and long-term stability can be achieved with high microbiocidal activity. For this purpose, the gel according to the invention comprises an inorganic silicate as thickener and an electrochemically activated starting saline solution which has a free chlorine content of more than 300 mg/l. In addition, a colored gel having the properties described above can be obtained by adding suitable pigments.

The present invention, as disclosed herein, provides an isolated peptide, and a composition or material comprising a hydrogel, for the delivery of an active agent. The hydrogel comprises one or more isolated peptides and an active agent encapsulated in the hydrogel. The hydrogel is at least partially in a β-sheet conformation. Further provided are a method for the encapsulation of an active agent in a hydrogel, a method for treating or diagnosing a condition or disease in a subject in need thereof.

This invention relates to a pharmaceutical preparation for the treatment of compromised tissue such as skin wounds and ulcers in humans and animals and a method of preparation. This is a multifunctional natural matrix meant for the treatment of compromised tissues which also relates to the anti-cancer transdermal patch for melanoma therapy. Further, the invention comprises for the treatment of Alzheimer's, and multiple sclerosis also. The composition consists of water-solubilized nano-sized formulation of non-aqueous solvent extract of phyto-pharmaceuticals in herbal, animal or synthetic biocompatible gel or on matrix coated or both. The composition is used as a topical device for the treatment of compromised tissues in its preferred embodiment.