A fluid processing system includes a fluid processing device and a fluid flow circuit. The device includes a pump configured to convey a priming fluid through the circuit. The pressure in a conduit of the circuit is measured while the pump is operated at a particular rate. When the magnitude of the pressure is less than the magnitude of a predetermined pressure at the end of a time interval, the pump is operated at an increased rate. When the magnitude of the pressure is greater than the magnitude of the predetermined pressure at the end of the time interval, the pump is instead operated at a decreased rate. The magnitude of the pressure in the conduit is again compared to the magnitude of the predetermined pressure after the pump has operated at the increased or decreased rate for the time interval to determine how to next adjust the operational rate.

A fluid processing method and an associated system are provided. The fluid processing method includes a first and second incubation stage which are performed sequentially without any intermediate steps. The fluid processing method creates a second incubation fluid product from a biological fluid.

A fluid processing system includes a fluid processing device and a fluid flow circuit. The device includes a pump configured to convey a priming fluid through the circuit. The pressure in a conduit of the circuit is measured while the pump is operated at a particular rate. When the magnitude of the pressure is less than the magnitude of a predetermined pressure at the end of a time interval, the pump is operated at an increased rate. When the magnitude of the pressure is greater than the magnitude of the predetermined pressure at the end of the time interval, the pump is instead operated at a decreased rate. The magnitude of the pressure in the conduit is again compared to the magnitude of the predetermined pressure after the pump has operated at the increased or decreased rate for the time interval to determine how to next adjust the operational rate.

The invention relates to a method performed ex vivo for removal of tumor cells from intraoperatively collected blood salvage, wherein a trifunctional antibody is used to bind a leukocyte, a tumor cell and an Fc-receptor positive cell. The invention also relates to the use of said ex vivo method for removal of tumor cells from intraoperatively collected blood salvage followed by reintroducing the so obtained purified blood salvage or of concentrates of erythrocytes purified by said method to a patient from whom said intraoperatively collected blood was obtained.

Devices and methods are provided herein for exchange between a first agent and a second agent. The device includes a first chamber having a first inlet and a first outlet with a first flow passageway extending between the first inlet and the first outlet for flowing a first agent through the first chamber. The device also includes a second chamber having a second inlet and a second outlet with a second flow passageway extending between the second inlet and the second outlet for flowing a second agent through the second chamber and a membrane positioned between the first flow passageway and the second flow passageway to allow exchange through the membrane of the first agent with the second agent. Methods of nitrosylating blood and methods of manufacturing the device are also provided.

A portable apheresis system for separating blood into blood components includes a cellular modem configured to transmit and receive information to and from the apheresis device via a cellular connection, and a connector operatively coupled with the cellular modem. The connector is configured to control the cellular modem to transmit and receive apheresis device registration information, establish, using the cellular modem, a cellular communication connection between an apheresis device and a cellular network after detecting the cellular network, transmit registration information relating to the apheresis device to a registration and connectivity computer software server via the wireless communication connection, receive an apheresis registration response from the registration and connectivity computer software server, the apheresis registration response including information relating to the apheresis device registration process, the registration process causing direct or indirect apheresis device communication with a blood establishment computer system remotely positioned relative to the apheresis device.

A method for determining a flow model for fluid within an apheresis machine includes determining a starting flow model for an apheresis procedure, determining details of a secondary device, and generating an updated flow model based on the starting flow model and the details of the secondary device. The secondary device is configured to connect to the apheresis machine for the apheresis procedure.

A kit for reduction of blood components in a blood-related medium (12) is disclosed, wherein it comprises a gel bead container (1) containing gel beads (2) and provided with an outlet tube (3), a drip chamber (4) provided with an inlet tube (5) and an outlet tube (6), a collection container (10) provided with an inlet tube (11), and a medium container (13) adapted to contain a blood-related medium (12) and provided with an outlet tube (15), wherein the outlet tube (3) of the gel bead container (1) is connectable with the inlet tube (5) of the drip chamber (4) via a sterile connecting device, wherein the outlet tube (6) of the drip chamber is connectable with the inlet tube (11) of the collection container (10) via a sterile connecting device, and wherein the outlet tube (15) of the medium container (13) is connectable to the inlet tube (5) of the drip chamber (4) via a sterile connecting device, as well as a method for reduction of blood components in a blood-related medium (12) by use of said kit.

A system for blood cell separation, comprising: a separation chamber (10) comprising an inlet port for blood (12), an outlet port for plasma (14) and at least an outlet port for cellular blood components (16) for the separation of whole blood; a blood pump (20) for pumping whole blood into the inlet port for blood (12); a plasma pump (22) for pumping plasma and/or target cells from the outlet port for plasma (14) out of the separation chamber (10); a red blood cell tube (30) comprising a first end (32) and a second end (34), wherein the first end (32) of the red blood cell tube (30) is connected to the outlet port for cellular blood components (16) for allowing red blood cells to leave the separation chamber (10); and a drip chamber (40) comprising a reservoir (42) and an inlet (46), wherein the second end (34) of the red blood cell tube (30) is connected to the inlet (46), wherein the second end (34) of the red blood cell tube (30) extends into the volume of the reservoir (42) for pressure equalization during pumping from the outlet port for plasma (14).