A column for removal of a component from a fluid is disclosed. The column has a compartment with a cross sectional area. The compartment contains beads having a diameter. A ligand selected to bind to the component is coupled to the beads. The cross-sectional area and bead diameter are selected to maintain a flow velocity of the fluid within the compartment below a first threshold, thereby reducing leaching of the ligand into the fluid. Also described herein is an adsorbent comprising a ligand that is attached to a substrate by an amine bond, wherein the ligand is resistant to dissociation from the substrate.

Devices, systems, and methods herein relate to controlling a temperature (e.g., thawing) of a low volume biological substance. In some variations, a container enclosure for use with a device configured to control a temperature of a biological substance may comprise an adapter configured to receive a container comprising the biological substance.

A system for splitting a fluid includes a source support configured to support a source container and a satellite support configured to support a satellite container fluidly connected to the source container. A weight scale is associated with each of the supports. The system also includes a clamp system and a controller. The controller determines a plurality of possible distributions of the fluid between the source container and the satellite container based at least in part on the concentration or amount of said constituent and the combined weight measured by each weight scale, then controls the clamp system to selectively allow and prevent fluid flow from the source container to the satellite container so as to distribute the fluid between the source container and the satellite container according to one of the distributions, with at least one of the possible distributions being an uneven distribution of the fluid.

A column for removal of a component from a fluid is disclosed. The column has a compartment with a cross sectional area. The compartment contains beads having a diameter. A ligand selected to bind to the component is coupled to the beads. The cross-sectional area and bead diameter are selected to maintain a flow velocity of the fluid within the compartment below a first threshold, thereby reducing leaching of the ligand into the fluid. Also described herein is an adsorbent comprising a ligand that is attached to a substrate by an amine bond, wherein the ligand is resistant to dissociation from the substrate.

Disclosed is a polymer for capturing or separating leukocytes. The polymer is prepared by a polymerization reaction of monomers containing an amino and a hydroxyl. The monomer containing an amino and a hydroxyl has the structure of formula (1): ##STR00001##
In formula (1), R1 is independently selected from the group consisting of a hydrogen, a methyl, an ethyl, a hydroxyl, any one of C1 to C12 long carbon chains, and a benzene ring, R2 is independently selected from the group consisting of a hydrogen, a methyl, an ethyl, any one of from C1 to C6 long carbon chains, an amino and a benzene ring, and n is an integer of 1 to 5.

The present invention relates to an X-ray irradiator for single blood bags, comprising: an X-ray irradiator main body provided with a chamber configured to safely hold a single blood bag therein and an X-ray tube configured to irradiate the chamber with X-rays; a loading part configured to load the blood bag; and a transfer part configured to transfer the blood bag between the loading part and the chamber to which X-rays are to be emitted. The X-ray irradiator for single blood bags according to the present invention can treat a single blood bag with X-rays, such that treatment optimized for a small amount of a blood bag can be performed, and a system configuration can be simplified by using an X-ray tube.

A blood processing filter includes a container having 2 ports respectively functioning as an inlet for a liquid to be processed and as an outlet for the processed liquid, and a filtration medium filled in the container, wherein an airflow resistance of the filtration medium is 55.0 kPa.Math.s/m or more and less than 85.0 kPa.Math.s/m, the filtration medium includes a filter material A having an airflow resistance per unit basis weight of 0.01 kPa.Math.s.Math.m/g or more and less than 0.04 kPa.Math.s.Math.m/g and a filter material B having an airflow resistance per unit basis weight of 0.04 kPa.Math.s.Math.m/g or more, at least a part of the filter material A is disposed on a side closer to the inlet for a liquid to be processed than the filter material B, and a sum of airflow resistances of the filter material A is 6.0 kPa.Math.s/m or more.

A device for pooling a blood component stored in source containers includes a pump or pumps configured to pump a fluid in a first direction and a second direction and receive a pump line having a first end connected to the source containers. A pool clamp is configured to receive a pool line having a first end connected to a second end of the pump line and a second end connected to a pool container. A wash clamp is configured to receive a wash line having a first end connected to the second end of the pump line and a second end connected to a wash media container. A controller is configured to open the pool clamp, close the wash clamp and operate the pump in the first direction and to alternatively close the pool clamp, open the wash clamp and operate the pump in the second direction.

Provided herein are compositions and kits including a pathogen-inactivated cryoprecipitate suitable for infusion into a subject at least 1 day after thawing. The methods are useful in the efficient preparation of cryoprecipitates with desirable characteristics, including pathogen-inactivated cryoprecipitates that are suitable for infusion into a subject at least 1 day after thawing.

A filter material for removing leukocytes including a nonwoven fabric composed of polyester fibers, the nonwoven fabric having a first endothermic peak at a melting point and a second endothermic peak having a maximum in a temperature range from 155° C. to 225° C. in a DSC curve obtained by differential scanning calorimetry (DSC).