A multi-stage system for warming blood that enables safe and rapid blood transfusions in the field. The first stage of the system is a rapid blood warming device that heats blood quickly from cold storage to body temperature. This stage may use a high-energy power source, such as AC power, that is available in a facility such as a hospital. The second stage is a portable heated blood transport device into which heated blood bags are placed for transportation to a patient. This device keeps the blood bags warm using battery power. Because blood bags are pre-heated with the rapid warming device, the transport device can be lightweight and portable. An optional third stage is a transfusion temperature regulating device that boosts the final temperature of blood just before it enters the patient. All three devices may have sensors and controllers that maintain blood temperature within desired ranges.

The invention relates to a system, and the associated method for using said system, for treating haemorrhagic fluid previously taken from a patient for the purpose of autotransfusion, comprising a unit for treating (100) haemorrhagic fluid, said treatment unit (100) comprising: a filtration device (110) for tangential filtration comprising a filtration membrane (113) arranged in a housing (114) so as to separate an intake chamber (111) from a discharge chamber (112), the intake chamber (111) and the discharge chamber (112) each having an inlet (111a; 112a) and an outlet (111b; 112b) for fluids; a treatment pouch (140) having an inlet (140a) and an outlet (140b) fluidically connected by a recirculation line (150) to the outlet (111b) and to the inlet (111a) of the intake chamber (111) of the filtration device (110), respectively, allowing haemorrhagic fluid to circulate in the recirculation line (150) in a direction going from the outlet (140b) of the treatment pouch (140) to the inlet (140a) of the treatment pouch (140) through the intake chamber (111) of the filtration device (110); a cleaning line (180) fluidically connected to the inlet (112a) of the discharge chamber (112) of the filtration device (110) to convey cleaning fluid into said discharge chamber (112); and a first flow regulation member (181) arranged to regulate the flow in the cleaning line (180) and a second flow regulation member (131) arranged to regulate the flow in a discharge line (130) fluidically connected to the outlet (112b) of the discharge chamber (112) of the filtration device (110), so as to be able to control the pressure of cleaning fluid in the discharge chamber (112).

A platelet incubator usable as a lid for a refrigerated container includes a heating plate and a transparent cover. The heating plate has an aluminum top plate, an aluminum middle plate with an opening into which a silicon mat heater is placed, and a 5052 aluminum alloy bottom plate, with an aperture through which the wires providing electrical energy to the silicon mat heater are placed. The temperature is continuously monitored, and a log is kept for printout, allowing the platelet incubator to meet relevant compliance requirements. An alarm is activated if the temperature of the platelets exceeds twenty-three degrees Celsius, or falls under twenty-one degrees Celsius.

A method of treating soft tissue conditions. A harvesting device is provided. The harvesting device is operably connected to a tissue processing device using tubing. An aperture is formed in a bone. The bone has an interior. The harvesting device is inserted through the aperture in the bone and into the interior of the bone. The harvesting device is manipulated to dissociate connective tissue progenitor cells in the interior of the bone. Tissue is aspirated from the interior of the bone. The connective tissue progenitor cells are separated from the aspirated tissue. The separated connective tissue progenitor cells are injected in a region of a body that is experiencing a soft tissue condition to treat the soft tissue condition.

The present invention relates to a filter assembly for filtering a body fluid comprising a filter holder and a filter system downstream of the filter holder; wherein the filter system and the filter holder are in contact with each other, wherein the filter system comprises a cuboid frame structure with six rectangular surface areas A1-A6, and wherein five of the six surface areas A1-A5 are covered by a filtering media, and wherein the sixth surface area A6 is in contact with the filter holder.

The present disclosure provides apparatuses and systems for delivering a measureable absorbed-dose of a gaseous activating agent to a fluid including a biological liquid and/or cells. The apparatuses or systems include a gas-fluid contact device configured to controllably rotate or oscillate a control member having an interior surface in contact with the fluid and a control system configured to control rotation or oscillation of the contact member by the gas-fluid contact device. In some embodiments, the control system is further configured to control absorption of the gaseous activating agent by the fluid. The present disclosure also provides methods of treating a fluid including a biological liquid or cells with a gaseous activating agent to controllably activate the fluid.

Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, positioning a distal portion of a catheter proximate to the clot material within the blood vessel. The method can further include coupling a pressure source to the catheter via a tubing subsystem including a valve or other fluid control device and, while the valve is closed, activating the pressure source to charge a vacuum. The valve can then be opened to apply the vacuum to the catheter to thereby aspirate at least a portion of the clot material from the blood vessel and into the catheter.

A device for aseptic delivery of biological material from a vial includes a tubular barrel, a filter assembly, and a dispersion funnel assembly. The tubular barrel includes a receiving end to accept at least a portion of the vial within the tubular barrel, and a dispensing end opposite the receiving end. The filter assembly is fluidly connected to the dispensing end of the tubular barrel. The dispersion funnel assembly is configured to connect to the vial, and to be disposed at least partially within the tubular barrel. The dispersion funnel assembly has an open configuration to disperse the biological material from the vial into the tubular barrel between the dispersion funnel assembly and the filter assembly, and a closed configuration to force the dispersed biological material through the filter assembly when the dispersion funnel assembly is moved toward the dispensing end of the tubular barrel.

Process and system for acellular therapy in a human subject are provided. The process and system relate to an acellular therapy using therapeutic extracellular vehicles fused to biological material obtained from the subject, via transfusion by extracorporeal systems. The process for acellular therapy is in a subject in need of such therapy.

A method is provided for removing red blood cells from a suspension comprising red blood cells, white blood cells, platelets and plasma using a spinning membrane separator. The method comprises: a) flowing whole blood into the gap of the spinning membrane separator; b) collecting red blood cells and white blood cells in the gap and passing plasma and platelets through the membrane; c) introducing a first quantity of lysing buffer into the gap; d) incubating the red blood cells, white blood cells and lysing buffer in the gap for a period of time to cause a lysis reaction with the red blood cells; e) introducing a second quantity of lysing buffer into the gap to displace the first quantity of lysing buffer and a first quantity of red blood cell debris out of the gap; f) introducing a first quantity of wash buffer into the gap to quench the lysis reaction and displace the second quantity of lysing buffer and a second quantity of red blood cell debris out of the gap; and g) introducing a second quantity of wash buffer into the gap to flow washed white blood cells out of the housing.