A system for intra-operative blood salvage autotransfusion is provided. The system comprises at least one inlet configured to receive whole blood of a patient; at least one curvilinear microchannel in fluid flow connection with the at least one inlet, the at least one curvilinear microchannel being adapted to isolate circulating tumor cells in the whole blood, based on cell size, along at least one portion of a cross-section of the at least one curvilinear microchannel; and at least two outlets in fluid flow connection with the at least one curvilinear microchannel, at least one outlet of the at least two outlets being configured to flow the circulating tumor cells isolated from the whole blood, and at least one other outlet of the at least two outlets being configured to flow at least a portion of a remainder of the whole blood, cleansed of the isolated circulating tumor cells, for return to the patient.

A system for washing red blood cells, comprising a separator configured to separate a quantity of blood into concentrated red blood cells having a hematocrit of at least 60% and a volume of 150-250 mL, and a supernatant component. The system comprises a flow controller configured to remove the supernatant component to provide an initial red blood cell concentrate; combine 50-500 mL of an additive solution with the red blood cell concentrate to provide an intermediate red blood cell product intended for storage for 42 days or less, wherein the intermediate red blood cell product at the end of storage has an osmolarity value between 202-479 mOsm/L; and wash the intermediate red blood cell product comprising the osmolarity value between 202-479 mOsm/L with a washing solution having an osmolarity value higher than that of the intermediate red blood cell product comprising the osmolarity value between 202-479 mOsm/L.

Flexible housing filters for filtration of fluids and methods of making such filters are disclosed. The filters may include one or more peripheral seals in the flexible housing.

A process for the sequential processing of opaque and transparent biological fluids such as whole blood, apheresis blood, bone marrow blood, umbilical cord blood, buffy coat or cultured cells by processing steps in a hollow cylindrical centrifugal processing chamber (300) which is part of a disposable set. At least three different procedures selected from washing, incubation, transduction, separation, density gradient separation, dilution and volume adjustment are each carried out once or repeated a number of times according to a given processing profile in the processing chamber. Each procedure involves an input into the processing chamber, an operation in the processing chamber and an output from the processing chamber by displacement of a piston (310). The at least three different procedures are sequentially chained one after the other to constitute an overall sequential operation in the processing chamber and its disposable set. A first application is incubation for binding magnetic beads with human blood cells or stem cells. A second application is transduction by which foreign genetic material is inserted into human blood cells or stem cells by a virus. A third application is reconditioning biological fluids to achieve reproducible concentration and volumes of blood cells or stem cells.

The present technology discloses a cost-effective, single use bag or container for storing biological substances that incorporates on its inner wall an electronic device that is configured to measure physiological and/or physical parameters of the enclosed biological substances, such as source history, identification, demographics, time stamping, temperature, pH, conductivity, glucose, O.sub.2, CO.sub.2 levels etc. The electronic device of the disclosed bag comprises a sensor configured to measure physiological and/or physical parameters of the biological substances enclosed within the bag, and a radio-frequency (RF) device communicably coupled to the sensor and configured to: (a) acquire from the sensor data associated with the measured parameters, (b) store the acquired sensor data in nonvolatile memory, and (c) communicate the stored data wirelessly to a RF reader.

A blood processing apparatus (1) comprises a measurement device (8) having a first chamber element (80) for measuring a haematocrit value of a blood fluid, the first chamber element (80) comprising a first inlet port (800) connectable to a first reservoir container (2) for allowing a flow from the first reservoir container (2) into the first chamber element (80) and a first outlet port (801) for allowing a flow out of the first chamber element (80), and the second chamber element (81) comprising a second inlet port (810) for allowing a flow into the second chamber element (81) and a second outlet port (811) connectable to a second reservoir container (3) for allowing a flow out of the second chamber element (81) towards the second reservoir container (3). The blood processing apparatus furthermore comprises a first pump mechanism (600) for pumping a blood fluid in a flow direction (F1) from the first reservoir container (2) towards the blood processing apparatus (1), and a second pump mechanism (610) for pumping a blood fluid in a flow direction (F2) from the blood processing apparatus (1) towards the second reservoir container (2). Herein, the first pump mechanism (600) is located upstream of the first inlet port (800) of the first chamber element (80) and the second pump mechanism (610) is located upstream of the second inlet port (810) of the second chamber element (81). In this way a blood processing apparatus comprising a measurement device is provided which in an easy and reliable manner allows for a measurement of in particular a haematocrit value in the incoming blood flow as well as the outgoing blood flow.

A cell washing apparatus is provided to wash a cell-containing fluid. The apparatus is arranged to exchange one or more exchangeable entities from a cell-containing first fluid, and comprises, a first fluid conduit and a second fluid conduit, the second fluid conduit separated from the first fluid conduit by a semi-permeable membrane disposed therebetween; the first fluid conduit having a first fluid inlet and a first fluid outlet, the first fluid conduit arranged to transport the first fluid in a first direction between the first fluid inlet and the first fluid outlet; the second fluid conduit being arranged to house a second fluid; wherein the semi-permeable membrane comprises a plurality of pores arranged to permit transport of said one or more exchangeable entities from the first fluid to the second fluid; wherein the one or more exchangeable entities comprise free haemoglobin and/or blood plasma; and wherein the first fluid is whole blood isolated from a human body, or packed red blood cells. The cell washing apparatus of the present invention aims to solve the problem of harmful species that accumulate in a cell-containing fluid (such as, for example, transfusion blood) during storage and other applications, in which it is desired to transfer red blood cells to a clean suspending liquid.

Provided are methods for preparing pathogen-inactivated whole blood and other pathogen-inactivated blood product compositions, as well as kits and compositions related thereto.

A blood processing apparatus (1) comprises a measurement device (8) having at least one chamber element (80, 81) for receiving a blood fluid, wherein the at least one chamber element (80, 81) extends along a longitudinal axis (L) and comprises a circumferential wall (804, 814) extending about the longitudinal axis (L), a bottom wall (803, 813) and a top wall (805, 815) together defining a flow chamber (802, 812), the at last one chamber element (80, 81) further comprising an inlet port (800, 810) for allowing a flow of a blood fluid into the flow chamber (802, 812) and an outlet port (801, 811) for allowing a flow of a blood fluid out of the flow chamber (802, 812). The blood processing apparatus (1) further comprises a holder device (9) for holding the measurement device (8), the holder device (9) comprising a base (90) having a reception opening (900) for receiving the measurement device (8) and a closure element (91) movably arranged on the base (90) for locking the measurement device (8) in an inserted position in the reception opening (900). An ultrasonic sensor element (92, 93) of the holder device (9) is arranged on the base (90) and adapted to produce an ultrasonic sensor signal (P) for measuring a haematocrit value of a blood fluid in the flow chamber (802, 812). Herein, the ultrasonic sensor element (92, 93), in the inserted position of the measurement device (8), faces the bottom wall (803, 813) of the at least one chamber element (80, 81) for transmitting the ultrasonic signal (P) into the flow chamber (802, 812) through the bottom wall (803, 813). In this way a blood processing apparatus comprising a holder device for a measurement device is provided which allows to easily insert the measurement device into the holder device and allows for a reliable measurement of, in particular, a haematocrit value of a blood flow through the measurement device.

A tubing set for use in a blood processing apparatus comprises a measurement device (8) having at least one chamber element (80, 81) for measuring a haematocrit value of a blood fluid, wherein the at least one chamber element (80, 81) extends along a longitudinal axis (L) and comprises a circumferential wall (804, 814) extending about the longitudinal axis (L) and encompassing a flow chamber (802, 812), the at last one chamber element (80, 81) further comprising an inlet port (800, 810) for allowing a flow of a blood fluid into the flow chamber (802, 812) and an outlet port (801, 811) for allowing a flow of a blood fluid out of the flow chamber (802, 812). The tubing set furthermore comprises an inlet-side tube section (21, 31) connected to the inlet port (800, 810) and an outlet-side tube section (22, 30) connected to the outlet port (801, 811). Herein, the inlet port (800, 810) and the outlet port (801, 811) are arranged on the circumferential wall (804, 814) and are displaced with respect to each other along the longitudinal axis (L). In this way a tubing set comprising a measurement device is provided which in an easy and reliable manner allows for the measuring of a haematocrit value of a blood fluid.