A flow regulation device is disclosed. The flow regulation device is fluidly located between a fluid source and a dialysis machine. In some embodiments, the flow regulation device includes an inlet in fluid communication with the fluid source to receive a fluid and an outlet in fluid communication with the dialysis machine to provide the fluid. The flow regulation device also includes a closed volume defined by walls that are configured to expand and contract to provide a variable internal volume. A cross-sectional width of the variable internal volume of the flow regulation device is larger than diameters of the inlet and the outlet to smooth changes in a draw rate of the fluid from the dialysis machine.

A blood processing apparatus includes an optional heat exchanger and a gas exchanger disposed within a housing. In some instances, the gas exchanger can include a screen filter spirally wound into the gas exchanger such that blood passing through the gas exchanger passes through the screen filter and is filtered by the spirally wound screen filter a plurality of times.

Systems, methods, and/or apparatuses may be operative to perform a dialysis process that includes a displacer infusion process. In one embodiment, a method for determining a displacer compound may include constructing a plurality of target protein quantitative structure-activity relationship (QSAR) models, one for each of the plurality of binding sites, analyzing a set of candidate compounds using the plurality of QSAR models to determine a set of at least one potential compound with an affinity for binding to each of the plurality of binding sites, and selecting at least one displacer compound from the set of at least one potential compound. Other embodiments are described.

Dialysis machines comprising a feed arrangement to supply a dialysis fluid to a dialyzer during dialysis treatment and a return arrangement to remove the dialysis fluid from the dialyzer during dialysis treatment and forward it to an exit; a feed recirculation circuit to allow a fluid of the feed arrangement to be re-circulated in a fluid loop path comprising, at least a portion of, the feed arrangement and the feed recirculation circuit and a return recirculation circuit to allow a fluid of the return arrangement to re-circulate in an auxiliary fluid loop path comprising, at least a portion of, the return arrangement and the return recirculation circuit. A controller configured to perform disinfection by re-circulating a disinfectant and/or a heated fluid through said fluid loop path and/or through said auxiliary fluid loop path. The dialysis machine further comprises a feed forward arrangement connected to the fluid loop path and arranged to enable a fluid of the feed arrangement to be forwarded to the exit by-passing the auxiliary fluid loop path.

The present invention relates to a pump, comprising a pump actuator (2) having at least one electroactive polymer, as well as at least one return element (8, 9) which returns a displacement element (5) of the pump after a pump stroke to a defined position. The invention further relates to a metering unit and to a medical apparatus comprising such a pump.

The present invention relates to a pump, comprising a pump actuator (2) having at least one electroactive polymer, as well as at least one return element (8, 9) which returns a displacement element (5) of the pump after a pump stroke to a defined position. The invention further relates to a metering unit and to a medical apparatus comprising such a pump.

Systems, methods, and/or apparatuses may be operative to perform a dialysis process that includes a displacer infusion process. The dialysis machine may include at least one processor and a memory coupled to the at least one processor, the memory comprising instructions that, when executed by the processor, may cause the at least one processor to access dialysis information for a dialysis process performed by a dialysis machine, the dialysis information indicating a target substance to be displaced from a binding compound by a displacer, and determine an infusion profile for infusing the displacer into a patient during a displacer infusion process of the dialysis process, the infusion profile determined based on the dialysis information and an infusion constraint. Other embodiments are described.

A system and method is provided for training operators (e.g., users), including new nurses or nephrologists as well as patients or their family members, to learn the intricacies of dialysis (e.g., hemodialysis) treatment through a simulation. The simulation may afford users the ability to fail catastrophically in simulated dialysis treatment, see the consequences, learn and internalize complex algorithms, and develop the ability to think in a time pressured situation. The simulation may thereby provide a safe learning environment for experiencing decisions and consequences of these decisions when performing a dialysis treatment. In some instances, the simulation may be in a mobile application form factor to encourage more ubiquitous use on personal devices, which may provide ease of access for the dialysis training. The simulation may further include time-based simulated scenarios that increase in difficulty and complexity between levels.

A dual lumen drainage cannula configured for use in a veno-arterial extracorporeal membrane oxygenation (VA ECMO) system includes a first drainage tube having a proximal end, a distal end, and at least one aperture defined proximate its distal end and in fluid communication with the lumen of the first drainage tube, and a second drainage tube having a proximal end, a distal end, and at least one aperture defined proximate its distal end and in fluid communication with the lumen of the second drainage tube. The dual lumen drainage cannula further includes a flow restrictor disposed within the lumen of at least one of the first and second drainage tubes, configured to adjust the flow distribution of blood flow through the lumens of the first and second drainage tubes.

An oxygenator having a plurality of porous hollow fiber membranes for gas exchange to treat blood is manufactured by dissolving a silicone compound in an organic solvent having a surface tension of less than 70 dyn/cm to prepare a coating solution, and bringing an inner surface of the hollow fiber membranes into contact with the coating solution under a negative pressure of 50 hPa or more and 150 hPa or less to form a silicone compound-containing coating layer on the inner surface. An antithrombotic polymer compound-containing coat can be provided directly on an outer surface of the hollow fiber membranes.