Methods, systems, and kits are provided for performing hemodialysis, hemodiafiltration, and peritoneal dialysis on a portable machine suitable for both clinical and home use. Peritoneal dialysate can be flowed into and out of the peritoneal cavity, and can also be regenerated within the system, without the need for introducing fresh dialysate. Common hardware and software can be utilized for both peritoneal dialysis and other forms of dialysis such as hemodialysis, hemofiltration, and hemodiafiltration, allowing for facile transition between different dialysis modes using the same dialysis machine.

A dialysis system (e.g., a hemodialysis (HD) system) can be designed to operate in alternative environments, such as disaster relief settings or underdeveloped regions. The dialysis system can include a solar panel for generating electricity to power the dialysis machine and an atmospheric water generator for extracting water from ambient air. The extracted water can be used to generate dialysate and saline on-site. One or more of the components of the dialysis machine can be discrete components that are configured to facilitate fast shipping and simple on-site assembly (e.g., at a remote location). In some implementations, the discrete components may be configured to be attached to an existing dialysis system (e.g., a dialysis system designed for operation in a traditional environment) to permit the dialysis system to operate in an alternative environment.

A dialysis system (e.g., a hemodialysis (HD) system) can be designed to operate in alternative environments, such as disaster relief settings or underdeveloped regions. The dialysis system can include a solar panel for generating electricity to power the dialysis machine and an atmospheric water generator for extracting water from ambient air. The extracted water can be used to generate dialysate and saline on-site. One or more of the components of the dialysis machine can be discrete components that are configured to facilitate fast shipping and simple on-site assembly (e.g., at a remote location). In some implementations, the discrete components may be configured to be attached to an existing dialysis system (e.g., a dialysis system designed for operation in a traditional environment) to permit the dialysis system to operate in an alternative environment.

Systems and methods include a heat transfer body with opposing major surfaces formed from a thermally conductive substrate in intimate thermal interaction with an alumina exterior surface that extends across the major surfaces of the body. In an illustrative example, the heat source may be a substantially planar, silicone-based heater source (P-SBHS). The heat transfer body may be configured to thermally interact, for example, heat from a heat source proximate a first of the major surfaces to a second of the major surfaces. A temperature sensor module may be located, for example, proximate to the first major surface such that a temperature sensor thermally interacts with the first major surface. The temperature sensor module may, for example, insulate the temperature sensor from the P-SBHS.

Systems and methods include a heat transfer body with opposing major surfaces formed from a thermally conductive substrate in intimate thermal interaction with an alumina exterior surface that extends across the major surfaces of the body. In an illustrative example, the heat source may be a substantially planar, silicone-based heater source (P-SBHS). The heat transfer body may be configured to thermally interact, for example, heat from a heat source proximate a first of the major surfaces to a second of the major surfaces. A temperature sensor module may be located, for example, proximate to the first major surface such that a temperature sensor thermally interacts with the first major surface. The temperature sensor module may, for example, insulate the temperature sensor from the P-SBHS.

In one aspect, a system includes a blood treatment machine; a dialyzer configured to be coupled to the blood treatment machine, the dialyzer including a dialyzer housing defining a blood inlet and a blood outlet; a bundle of hollow fibers within an interior of the dialyzer housing; a pumping device drivable to force blood received from the blood inlet through lumens of the bundle of hollow fibers and out the blood outlet; a dialysate inlet port in fluid communication with a dialysate flow path that includes space in the interior of the dialyzer housing between the bundle of hollow fibers; and a dialysate outlet port in fluid communication with the dialysate flow path. The system further includes a fluid conditioning system configured to (i) prepare and supply fresh dialysate to the dialyzer via the dialysate inlet port, and (ii) receive spent dialysate from the dialyzer via the dialysate outlet port, recycle the spent dialysate, and supply the recycled dialysate to the dialyzer via the dialysate inlet port.

Embodiments pertain to a peritoneal dialysate production and delivery (PD) system configured to produce fresh dialysate for use in peritoneal dialysis of a patient, the system comprising: a water inlet, a water treatment device that is fluidly connectable or connected via the water inlet to a water source and configured to treat water received from the water source to generate treated water; a concentrate supply device that is in fluid communication with the at least one water treatment device to add concentrate comprised in the concentrate supply device to the treated water to generate fresh dialysate fluid; tubing having a lumen for supplying the fresh dialysate fluid to a patient body via a flow path; and a tubing disinfectant supply device that contains and/or that is operable to receive disinfectant agents, wherein the tubing disinfectant supply device is in fluid connection with the tubing for disinfecting at least a portion of the tubing.

Damping devices, including damping devices for automated peritoneal dialysis (APD) systems, and associated systems, devices, and methods are disclosed herein. In one embodiment, a damping device includes a body portion, a first membrane, and a second membrane. The body portion can include a first side, a second side opposite the first side, an inlet, and a cavity fluidly coupled to the inlet. The cavity can be defined at least in part by a lumen in the body portion extending from the first side to the second side. The first membrane can be affixed to the first side of the body portion such that the first membrane hermetically seals the cavity at the first side. The second membrane can be affixed to the second side of the body portion such that the second membrane hermetically seals the cavity at the second side.

A peritoneal dialysis cassette and an interface between the cassette and a peritoneal dialysis system is provided. The peritoneal dialysis cassette can include one or more fluid passages connecting a plurality of inlet/outlet ports, with one or more linear actuators usable to selectively direct fluid through the peritoneal dialysis cassette.

A peritoneal dialysis cassette and an interface between the cassette and a peritoneal dialysis system is provided. The peritoneal dialysis cassette can include one or more fluid passages connecting a plurality of inlet/outlet ports, with one or more linear actuators usable to selectively direct fluid through the peritoneal dialysis cassette.