An oxygen supply apparatus is configured to directly supply oxygen-containing gas to an user for inhalation while facilitating blood circulation of a specific portion of the user. The oxygen supply apparatus includes a power supply; an oxygen-containing gas source for providing the oxygen-containing gas; a gas catheter having one end thereof connected to the oxygen-containing gas source; an inhalator connected to the other end of the gas catheter; and a circulation facilitating device at least partially attached to the specific portion of the user. The circulation facilitating device includes a sonic oscillation circuit and a housing. The sonic oscillation circuit is configured to produce oscillation at a frequency ranging from 20 Hz to 10 MHz, and the housing encloses the sonic oscillation circuit in a watertight manner

An oxygen supply apparatus is configured to directly supply oxygen-containing gas to an user for inhalation while facilitating blood circulation of a specific portion of the user. The oxygen supply apparatus includes a power supply; an oxygen-containing gas source for providing the oxygen-containing gas; a gas catheter having one end thereof connected to the oxygen-containing gas source; an inhalator connected to the other end of the gas catheter; and a circulation facilitating device at least partially attached to the specific portion of the user. The circulation facilitating device includes a sonic oscillation circuit and a housing. The sonic oscillation circuit is configured to produce oscillation at a frequency ranging from 20 Hz to 10 MHz, and the housing encloses the sonic oscillation circuit in a watertight manner

A blood loop system for controlling blood oxygen saturation includes a conduit loop, a pump, a flow cell, a matter source, an aeration chamber, a collection chamber and an oxygen probe. The pump is coupled to the conduit loop and positioned to circulate blood through the conduit loop. The flow cell is positioned to measure a characteristic of the blood circulated through the conduit loop. The matter source includes a gas. The aeration chamber is coupled to the conduit loop and is in fluid communication with the matter source to enable the gas to combine with the blood. The collection chamber is in fluid communication with the aeration chamber and is positioned to receive the blood. The oxygen probe is positioned to measure an amount of oxygen in the blood.

A gas delivery system is provided. The gas delivery system includes a pump operable to receive blood from a patient. A gas transfer unit is in fluid communication with the pump and operable to receive the blood from the pump and deliver a therapeutic amount of xenon gas to the blood. A patient connector withdraws and/or infuses the blood into the patient.

According to some embodiments, a system may treat blood outside the body of a patient. The system may include one or more pumps configured to draw blood from a patient into a fluid flow path at a rate, for example, of 5-7 liters per minute. The system may include one or more heat exchangers coupled to the fluid flow path and configured to heat the blood, for example, to a temperature above 42 degrees Celsius and below 43.2 degrees Celsius.

According to some embodiments, a system may treat blood outside the body of a patient. The system may include one or more pumps configured to draw blood from a patient into a fluid flow path at a rate, for example, of 5-7 liters per minute. The system may include one or more heat exchangers coupled to the fluid flow path and configured to heat the blood, for example, to a temperature above 42 degrees Celsius and below 43.2 degrees Celsius.

A system for cardiopulmonary bypass, including: a cardiopulmonary bypass reservoir configured to store a blood; a pump in fluid communication with the cardiopulmonary bypass reservoir configured to provide pressure to the system; an oxygen source including a pressure regulator configured to regulate an oxygen pressure; an oxygenator fluidly connected to the pressure regulator of the oxygen source via an sweep gas inlet, wherein the sweep gas inlet is configured to have a subatmospheric pressure and the oxygenator is configured to oxygenate the blood; a vacuum regulator fluidly connected to the oxygenator via an sweep gas outlet, and configured to provide the subatmospheric pressure; a flow restrictor fluidly connected to the sweep gas inlet and configured to allow for a pressure drop from the oxygen source to the oxygenator; and an arterial filter fluidly connected to a blood outlet of the oxygenator and to the cardiopulmonary bypass reservoir.

A system for cardiopulmonary bypass, including: a cardiopulmonary bypass reservoir configured to store a blood; a pump in fluid communication with the cardiopulmonary bypass reservoir configured to provide pressure to the system; an oxygen source including a pressure regulator configured to regulate an oxygen pressure; an oxygenator fluidly connected to the pressure regulator of the oxygen source via an sweep gas inlet, wherein the sweep gas inlet is configured to have a subatmospheric pressure and the oxygenator is configured to oxygenate the blood; a vacuum regulator fluidly connected to the oxygenator via an sweep gas outlet, and configured to provide the subatmospheric pressure; a flow restrictor fluidly connected to the sweep gas inlet and configured to allow for a pressure drop from the oxygen source to the oxygenator; and an arterial filter fluidly connected to a blood outlet of the oxygenator and to the cardiopulmonary bypass reservoir.

The invention is a cooling unit for a heat exchanger, which preferably is a heat exchanger integrated in an oxygenator for the purpose of controlling the temperature of blood conveyed in an extracorporeal blood circuit. The cooling unit has a reservoir in which a liquid is stored, a reaction vessel comprises a reactant and which, in conjunction with the liquid, is able to initiate an endothermal reaction. A fluidic access is generated between the reservoir and the reaction vessel. A fluid line extends at least in part inside the reaction vessel which has an inlet line and outlet line, which are each connectable or connected in a fluid-tight manner to a hose system of the heat exchanger, which together with the hose system of the heat exchanger, provides least part of a fluid circuit.

The invention is a cooling unit for a heat exchanger, which preferably is a heat exchanger integrated in an oxygenator for the purpose of controlling the temperature of blood conveyed in an extracorporeal blood circuit. The cooling unit has a reservoir in which a liquid is stored, a reaction vessel comprises a reactant and which, in conjunction with the liquid, is able to initiate an endothermal reaction. A fluidic access is generated between the reservoir and the reaction vessel. A fluid line extends at least in part inside the reaction vessel which has an inlet line and outlet line, which are each connectable or connected in a fluid-tight manner to a hose system of the heat exchanger, which together with the hose system of the heat exchanger, provides least part of a fluid circuit.