Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration. These various features may enable long-term application to all dialysis and ultrafiltration related therapies, and also to other therapies and to applications including implantables, portables and wearables.

The present disclosure relates to improved semipermeable membranes based on acrylonitrile copolymers for use in dialyzers for the extracorporeal treatment of blood in conjunction with hemodialysis, hemofiltration or hemodiafiltration. The present disclosure further relates to methods of producing such membranes.

A dialysis device comprising a dialysis circuit for providing dialysis fluid and returning purified fluid to the dialysis circuit. The device comprises an evaporator/condenser device, provided with an evaporator bag and a condenser bag. The evaporator bag receives dialysis fluid from the dialysis bag and produces steam, whereby a concentrated dialysis fluid is left and drained to a drain bag. The condenser bag receives the steam produced in the evaporation bag and condenses the steam for producing pure water for being returned to said dialysis circuit. The evaporation and condensation takes place at a subatmospheric pressure, such as between 30 and 70 mmHg at a temperature of about 30 to 44 C. Heat energy is provided to the evaporation bag and the condenser bag is cooled. The cooled energy may be absorbed by a heat pump for delivery of heat to the evaporator bag.

The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications.

The present invention relates to systems and methods for filtration and/or dilution of fluids, in particular for the dialysis of blood. The systems comprise a filter device (10) having a fluid chamber (18) and comprising a first lid (20) having arranged thereon a first fluid port (22). The filter device (10) further comprises a second lid (30) having arranged thereon at least a second fluid port (32). The filter device (10) further comprises a plurality of hollow fibers (40) arranged within the housing (12), wherein each of the plurality of hollow fibers (40) comprises a semi-permeable membrane and defines a fluid channel extending longitudinally through an interior of the respective hollow fiber (40). Also, the filter device (10) comprises a fourth fluid port (50) and a fifth fluid port (52) both provided at the fluid chamber (18).

A hemocompatible adsorber for separating protein-bound uremic toxins contained in the blood of a patient and having a molecular mass of <500 g/mol regarding their carrier proteins, to adsorb the uremic toxins during hemodialysis. The hemocompatible adsorber including a polymer based on a cyclic oligosaccharide or a derivative thereof which is disposed on a solid carrier component. A device for hemodiafiltration including an extracorporeal circuit for receiving blood to be purified and a hemodialyzer connected to the blood circulation of a patient, wherein a hemocompatible adsorber is provided for separating protein-bound uremic toxins contained in the blood of a patient and having a molecular mass of <500 g/mol regarding their carrier proteins. The hemocompatible adsorber, which is disposed on a solid carrier component in at least one layer on the blood side within the hemodialyzer, includes a polymer based on a cyclic oligosaccharide or a derivative thereof.

A blood purification system is provided that is capable of effectively utilizing accumulated histories stored during blood purification treatment and that helps take a quick and appropriate action in response to any event that occurs unsteadily or any transition of a parameter. The blood purification system includes an extracting unit that searches histories accumulated in a storage unit and extracts, as reference histories, a plurality of histories each including any of events having occurred during the current session of blood purification treatment or a plurality of histories each including a parameter approximate to that observed during the current session of blood purification treatment; a list-creating unit that creates a list of the plurality of reference histories extracted by the extracting unit; and a display control unit that controls the list created by the list-creating unit to be displayed on a display unit.

The specification discloses a portable dialysis machine having a detachable controller unit and base unit. The controller unit includes a door having an interior face, a housing with a panel, where the housing and panel define a recessed region configured to receive the interior face of the door, and a manifold receiver fixedly attached to the panel. The base unit has a planar surface for receiving a container of fluid, a scale integrated with the planar surface, a heater in thermal communication with the planar surface, and a sodium sensor in electromagnetic communication with the planar surface. Embodiments of the disclosed portable dialysis system have improved structural and functional features, including improved modularity, ease of use, and safety features.

Hemodialysis systems are described. A hemodialysis system may include a dialysate flow path through which dialysate is passed from a dialysate reservoir, which includes a valved vent to atmosphere, to an ultrafilter. The dialysate flow path includes a pneumatically actuated diaphragm-based dialysate pump for pumping fluid from the dialysate reservoir to the ultrafilter. The hemodialysis system may include a controller for controlling pneumatic actuation pressure delivered to the dialysate pump and at least one valve connecting the dialysate reservoir vent to the atmosphere. The hemodialysis system may be configured to actuate the dialysate pump and the at least one valve to introduce air into the dialysate flow path and expel liquid from the dialysate flow path to a drain.

The invention relates to a portable ultrafiltration unit A which comprises a blood pump 7 for conveying blood and an ultrafiltration pump 6 for conveying ultrafiltrate. The invention further relates to a stationary device B for supplying dialysate to the portable ultrafiltration unit A, and to a medical treatment system which comprises an ultrafiltration unit and a device for supplying dialysate to the ultrafiltration unit. The ultrafiltration unit according to the invention is in the form of a unit to be connected to a stationary device for supplying dialysate to the ultrafiltration unit, in such a way that a fluid connection can be established for feeding in fresh dialysate and removing used dialysate. As a result, the ultrafiltration unit can not only be used for ultrafiltration, but also, when used in conjunction with the stationary device for supplying dialysate to the ultrafiltration unit, for a blood treatment as carried out by a conventional blood treatment device. It is merely necessary to connect the ultrafiltration unit A to the device B for supplying dialysate to the ultrafiltration unit. There is no need to detach the patient connections 27A, 27B of the venous and arterial blood lines 27, 28 or to attach said connections to the patient, as result of which the preparation time for a blood treatment can be reduced.