A portable hemodialysis system is provided including a dialyzer, a closed loop blood flow path which transports blood from a patient to the dialyzer and back to the patient, and a closed loop dialysate flow path which transports dialysate through the dialyzer. In addition, the hemodialysis system includes two reservoirs which can be alternately placed in the dialysis flow path using various controllable fluid valves. The weight, and therefore the level of dialysate, of each reservoir is measured by a preferred level sensor having a strain measuring device which includes a load cell and a tilt sensor. The load cell and tilt sensor are electrically connected to a processor for sending force and tilt measurements to the processor. The processor may analyze the tilt measurements to correct for any inaccurate measurements of the load cell caused by the tilt.

Techniques and apparatus for de-priming processes are described. For example, in one embodiment, an apparatus may include at least one processor and a memory coupled to the at least one processor, the memory may include instructions that, when executed by the processor, may cause the at least one processor to determine a priming volume of a primer fluid infused into a priming system associated with the patient during a priming phase of the dialysis treatment, cause an ultrafiltration rate of an ultrafiltration pump of the dialysis machine in fluid communication with the patient to be changed from a treatment ultrafiltration rate to a de-priming ultrafiltration rate to remove the priming volume over a de-priming time period, and cause, after the de-priming time period, the ultrafiltration rate of the ultrafiltration pump to be changed back the treatment ultrafiltration rate. Other embodiments are described.

Compounds, systems, kits, methods, and/or apparatuses may be operative to reduce amyloid beta (Aβ) peptide in a patient, including a central nervous system (CNS) of the patient and/or a periphery (non-CNS portion) of the patient. In some embodiments, a displacer fluid comprising a Aβ displacer may be introduced to the patient to bind to a blood protein, such as albumin, that binds Aβ (for instance, Aβ peptide or non-plaque Aβ) in the patient periphery. Binding of the displacer to the blood protein may facilitate more free Aβ peptide (for instance, Aβ monomers) in the periphery for clearance via natural processes, such as through the liver or kidneys, and/or artificial processes, such as dialysis. Increased removal of the free Aβ peptide in the periphery may ultimately lead to less Aβ peptide in the CNS, which may decrease Aβ plaque formation in Alzheimer's Disease (AD) patients. Other embodiments are described.

The present invention relates to an organizer for releasably accommodating components of blood tube sets for different extracorporeal blood treatment options, in particular for dialysis methods, by means of a blood treatment apparatus, as well as methods for manufacturing and preparing an organizer of the invention.

Apparatus and method for photo-chemical oxidation are disclosed herein. In one embodiment, a system for treating a dialysis fluid includes: a nanostructured photo-electrochemical anode; a source of light configured to illuminate the photo-electrochemical anode; and a cathode that is permeable to oxygen provided to the dialysis fluid and non-permeable to a liquid of the dialysis fluid. The photo-electrochemical anode is configured to remove urea from the dialysis fluid by converting the urea in the dialysis fluid into oxidation products through a photo electrochemical reaction.

The present invention relates to a dialysis machine having an extracorporeal circuit in which a dialyzer is located which has a chamber on the blood side which is flowed through by blood and a first pressure sensor, which is located upstream of the chamber on the blood side in the direction of flow of the blood, for determining a first pressure value and a second pressure sensor, which is located downstream of the chamber on the blood side in the direction of flow of the blood, for determining a second pressure value, wherein the dialysis machine has first means for determining the pressure difference between the second pressure value and the first pressure value, second means for determining the dynamic viscosity of the blood on the basis of the determined pressure difference, of the blood flow rate through the chamber on the blood side and of one or more characteristic properties of the dialyzer and third means for determining the hematocrit or the hemoglobin value of the blood on the basis of the determined viscosity, and wherein the dialysis machine has a control or regulation unit which is configured such that it sets the blood flow rate and/or the dilution rate and/or the ultrafiltration rate such that the time change of the hematocrit and/or of the hemoglobin value does not exceed a limit value or lies in a desired value range.

The present invention concerns an extracorporeal circuit for regional scoagulation of blood comprising a line for taking the blood from the patient, a first filtering unit, and a line for returning the blood to the patient defining a main circuit, the extracorporeal circuit comprising a secondary circuit for recirculation of the plasma water comprising: a calcium removal assembly adapted to provide a solution with low calcium content in said main circuit;
the extracorporeal circuit further comprising: first means for the infusion of said solution with low calcium content into said main circuit upstream of said first filtering unit and of said calcium removal assembly with respect to the blood flow direction in the main circuit and second means for the infusion of an electrolytic re-establishment solution located downstream of said first means with respect to the direction of the blood flow in said main circuit.

A hemodialysis system includes a dialyzer; a dialysis fluid circuit including a fresh dialysis fluid pump, and a used dialysis fluid pump; a blood circuit including a blood pump operable with an arterial line upstream of the dialyzer, a medical fluid source in fluid communication with the arterial line between a patient end of the arterial line and the blood pump, a drip chamber located along a venous line; a blood rinseback sequence wherein blood is transferred to the patient by the medical fluid, wherein the medical fluid is introduced from its source into the arterial line between an arterial line patient end and the blood pump, and flowed through the dialyzer, through the venous drip chamber along the venous line; and a blood circuit priming sequence initiated in the blood circuit via the arterial line.

The present disclosure describes a device and method to clear solutes from a patient's blood while maintaining fluid balance. In some implementations, the device and method is used to assist the filtration functions of a patient's liver or kidney. The device includes a plurality of hollow fibers that pass through a sequence of alternating filtration chambers and infusion chambers. The filtration chambers filter the patient's blood while the infusion chambers rehydrate the filtered blood.

A medical fluid management assembly includes a pneumatic manifold, a pump and valve engine, and a fluid manifold. The pneumatic manifold includes a plurality of pneumatic passageways and a plurality of pneumatic connectors. The pump and valve engine includes a plurality of valve chambers, at least one pump chamber, and a plurality of pneumatic connectors mated sealingly and releasably with the pneumatic connectors of the pneumatic manifold. The pump and valve engine also includes a plurality of fluid connectors. The fluid manifold includes a plurality of fluid pathways and a plurality of fluid connectors mated sealingly and releasably with the fluid connectors of the pump and valve engine.