Manifolds suitable for use in hemodialysis, hemofiltration, hemodiafiltration, and peritoneal dialysis are provided. One or more of the manifolds can include a manifold body and an external tube. The manifold body can include at least one conduit including a first conduit and at least one port including a first port in fluid communication with the first conduit. The external tube can be in fluid communication with the first port and can include a main segment, a first branch segment, and a second branch segment containing at least one bacterial filter. The first branch segment and/or second branch segment can include at least one flow restrictor. Dialysis machines, systems, and kits including one or more such manifold are also provided, as are methods of performing hemodiafiltration using such manifolds.

A device for extracorporeal blood treatment and a method for operating an extracorporeal blood treatment device provide for an ultrafiltrate pump of an ultrafiltration apparatus to be operated in a first and second operating mode. The ultrafiltrate pump is operated in the first operating mode in such a way that the pressure on the blood-side of the semipermeable membrane is higher than the pressure on the dialysate-side of the semipermeable membrane of a dialyser, so that during the first operating mode a predetermined amount of fluid is removed from an extracorporeal blood circuit via the semipermeable membrane of the dialyser. In the second operating mode, the ultrafiltrate pump is operated in such a way that the pressure on the blood-side of the semipermeable membrane is, at successive intervals, alternately higher and lower than the pressure on the dialysate-side of the semipermeable membrane of the dialyser, so that fluid is continuously removed from and supplied to the extracorporeal blood circuit via the semipermeable membrane (push/pull mode). Additional components, in particular a separate push/pull pump, are not required for operation of the blood treatment device in push/pull mode. This results in both lower dimensions and lower weight. Operation in push/pull mode can increase the service life of the dialyser and the clearance of the dialysis treatment can also be increased for certain substances.

The present invention pertains to an extracorporeal blood treatment device (1), preferably a hemodialysis device, hemofiltration device, or hemodiafiltration device, comprising a fluidic system (2) having a connection point (20) for adding substances, a detection arrangement (4) for detecting a flow of a substance at the connection point (20), wherein the detection arrangement is configured to generate a flow signal, when a flow of a substance is detected at the connection point (20), and a control unit (5), which is communicatively connected to the detection arrangement (4). The control unit (5) is furthermore configured to output a signal (50) in reaction to a received flow signal. The present invention furthermore pertains to a corresponding method for monitoring at least one connection point.

The present invention relates to an insert piece for a blood tubing set that includes a first connection site for connecting a first tubing portion of the blood tubing set to the insert piece; a second connection site for connecting a second tubing portion of the blood tubing set to the insert piece; a third connection site for connecting a third tubing portion of the blood tubing set to the insert piece; a first main line for conducting a first liquid through the insert piece; a second main line for conducting the first liquid through the insert piece; a secondary line for conducting a second liquid into at least one of the first main line, and the second main line; and a connection portion which connects both main lines to each other or to the second connection site.

An apparatus for extracorporeal treatment of fluid and a process of setting up a medical apparatus for the delivery or collection of fluids are disclosed. According to the apparatus and the process, a control unit (10) is configured calculate set values of two or more of the fluid flow rates by imposing that an emptying time of containers of fresh fluid (16, 20, 21, 26) and/or a filling time of a waste container is substantially same as, or multiple of, the emptying time of one or more of the other containers of fresh fluid.

A servicing regime for a disposable set of a medical fluid therapy machine is disclosed. In an example, a medical fluid delivery system includes a medical fluid therapy machine operating with a disposable set over multiple treatments to mix for each treatment at least one concentrate with purified water to form a medical fluid. The medical fluid delivery system also includes a sensor configured to measure an accuracy of the medical fluid mixed by the medical fluid therapy machine. The sensor is configured to produce a mixing accuracy output. The medical fluid delivery system further includes a computer programmed to analyze the mixing accuracy output provided by the sensor to determine whether the disposable set needs to be replaced.

A method for detecting occult hemorrhages is provided. The method comprises: obtaining, by a medical system comprising a blood monitoring system, a first hematocrit concentration prior to infusing a saline solution into a bloodstream of the patient; infusing, by the medical system, the saline solution into the bloodstream of the patient; obtaining, by the medical system, a second hematocrit concentration after infusing the saline solution into the bloodstream; determining, by the medical system, a first absolute blood volume based on the first hematocrit concentration and the second hematocrit concentration; generating, by the medical system, a notification indicating a potential occult hemorrhage based on the first absolute blood volume and a pre-defined absolute blood volume threshold; and providing, by the medical system, the notification indicating the potential occult hemorrhage.

The present disclosure relates to a blood line (108) comprising an infusion site (145) intended to inject into the line a solution comprising: —a first main channel (200) having a first passage section, —a second main channel (220) having a second passage section, —means for the formation (210) of a turbulence area located downstream from the first main channel, located upstream from the second main channel, these formation means comprising a first fluid passage means (224) defining a reduction (225) in the passage section and whose smallest passage section is smaller than the first passage section and smaller than the second fluid passage section, —a secondary channel (230) comprising an inlet (231) for letting in the solution and an outlet (232) in fluid communication with the first main channel or the means for the formation of a turbulence area or the second main channel.

The invention relates to a blood treatment device having at least one metering line which opens into a fluid circuit, wherein a conveyor module is arranged in the metering line and comprises a membrane pump and a valve which is arranged at the pressure side thereof and which can act both as a blocking valve and as a restricting valve.

A system for filling multiple sterile containers includes a filter with an inlet port and multiple outlet ports, the outlet ports being pre-attached to sterile containers by respective filling lines of each container. Each container has an interior and each of the respective filling lines are connected to a respective container interior. The respective filling lines are sealed to the outlet ports and the containers such that the container interiors are isolated from an external environment except the inlet port, via the filter, forming a combined interior volume which is sterile. A container that is connectable to an outlet port the system has a bladder, a first tube and a second tube connected to the bladder, and a sterilizing filter. The container, the first tube and the second tube, and the sterilizing filter are sterile before water is flowed through the sterilizing filter into the bladder.