A fluid collection loop includes a flexible tube having a first end and a second end, a connector, and a fluid component collection bladder. The connector is configured to couple the first end of the flexible loop and the fluid component collection bladder. The fluid component collection bladder includes a first chamber defined between a top end and a flow chamber separator, and a second chamber defined between a bottom end and the flow chamber separator. The flow chamber separator extends from a first end of the fluid component collection bladder towards a second end of the fluid component collection bladder and a gap exists between the fluid component collection bladder and the second end of the fluid component collection bladder.

A method includes detecting a beginning of a donation process; in response to detecting the beginning of the donation process, providing an output; determining an amount of time remaining for the donation process; in response to detecting the amount of time remaining for the donation process, updating the output; detecting a loss in pressure; in response to detecting the loss in pressure, updating the output; detecting an ending of the donation process; and in response to detecting the ending of the donation process, updating the output. The donation process may include a plasma donation using an apheresis machine. The detecting the beginning of the donation process may include detecting a flow of fluid. The output may include one or more of a light and a sound. The output may be provided on a side of an apheresis machine.

An apheresis system at least partially defines a chamber and includes centrifuge that is movable between lock and unlock states. The centrifuge includes a base, cover, lock assembly, and latch assembly. The cover engages the base and defines slots. The lock assembly is coupled to the base and rotates between latched and unlatched states. The lock assembly includes tabs and a protrusion. The tabs are in the slots of the cover. The protrusion at least partially defines a receptacle. The latch assembly is coupled to the base and includes a lever and engagement component attached thereto. In the latched state, the protrusion engages the engagement component to reduce or prevent rotation of the lock assembly. In the unlatched state, the lock assembly can rotate. In the lock state, the tabs are at least partially within the slots. In the unlock state, the cover is movable with respect to the base.

A method includes detecting a startup of an apheresis machine; in response to detecting start up, transmitting data to a server; determining, based on the data, whether software of the apheresis machine is current; receiving, in response to the data, a response from the server; and preventing usage of apheresis machine if the response indicates the software is not current. The data transmitted to the server may include one or more of a data log, a firmware version identifier, and an error log. The response may include a lockout signal. The response may include a software update. The software update may include a firmware update. The method may include automatically initiating installation of the software update. The method may include ceasing prevention of usage of the apheresis machine following installation of the software update.

A pump for fluids includes a rotor sub-assembly, a tubing pressure block, an inlet guide, an outlet guide, and a tubing guard. The rotor sub-assembly includes at least one roller. The tubing pressure block includes a raceway and at least one projection. The tubing pressure block is movable between a first position and a second position. The inlet guide includes an inlet tubing channel and is disposed proximate to a first side of the tubing pressure block. The outlet guide includes an outlet tubing channel and is disposed proximate to a second side of the tubing pressure block. The tubing guard is configured to engage with the inlet guide and the outlet guide when the tubing guard is in a closed position and is configured to expose the rotor sub-assembly, the tubing pressure block, the inlet guide, and the outlet guide when in an open position.

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

A device for separating blood plasma from whole blood includes a first reservoir and a second reservoir. The first reservoir is configured to receive a sample of whole blood including red blood cells and includes a collection region and a constricted region. The second reservoir is fluidically connected to the constricted region of the first reservoir, such that, responsive to centrifugal force applied to the device, the sample of whole blood disposed within the first reservoir separates into a first fraction and a second fraction. The first fraction is located in the collection region and includes blood plasma from which substantially all red blood cells have been removed. The second fraction is located in the second reservoir and includes blood plasma and red blood cells that have been removed from the first fraction by the centrifugal force. The constricted region inhibits the second fraction from entering the collection region.

The present disclosure provides a system for using an in-line processing device with an apheresis device. The system includes a pressure system that includes a container configured to receive cells collected using the apheresis device and is configured to change a pressure of the container so as to direct the cells collected using the apheresis device to the in-line processing device.

Method consists of placing a flexible container within a rigid frame and expanding the container by pneumatic or hydraulic pressure such that the walls of the container conform to the inside walls of the rigid frame thus forming a well-defined chamber. The system has the capability of reducing the volume of the chamber by adjusting the distance between the walls of the rigid container. The methods and systems so described are applicable to closed sterile systems that employ immunomagnetic isolation or purging of components from blood products. By providing a fixed volume and at least one surface upon which targeted entities can be magnetically deposited, target cells in the case of positive isolations can be magnetically held, flushed with wash buffers over them to remove entrapped cells and finally the recovery of product of extremely high purities and at high yields.

A system for increasing blood flow through a user's limb during a blood collection procedure includes an inflatable cuff that is worm around the user's limb. A pump and a deflation valve are in fluid communication with the inflatable cuff. A heating element and a temperature sensor are attached to the inflatable cuff. The system also includes a motion sensor. A controller is in communication with the pump, the deflation valve, the heating element and the temperature and motion sensors and detects a blood pressure or blood flow of the user, controls inflation and deflation of the inflatable cuff and controls energization of the heating element based on data from the motion sensor and the temperature sensor.