Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

A medical device includes a case obtained by mating a liquid-phase-portion case and a gas-phase-portion case to each other, a membrane member as an elastic member with which a liquid-phase portion covered by the liquid-phase-portion case and a gas-phase portion covered by the gas-phase-portion case are separated from each other, fixing parts and at which the liquid-phase-portion case and the gas-phase-portion case that are mated to each other are fixed to each other, holding surfaces and between which a peripheral edge of the membrane member is held, and a sealing part that seals the entirety of the peripheral edge of the membrane member held between the holding surfaces and. The medical device has a releasing part that releases the pressure in an air gap produced between the sealing part and the fixing parts.

A blood purification apparatus that includes a blood circuit including an arterial blood circuit provided with an arterial puncture needle and a venous blood circuit provided with a venous puncture needle with which an access vessel is puncturable, the blood circuit allowing blood of the patient to extracorporeally circulate; a blood purifier connected to the arterial blood circuit and to the venous blood circuit and that purifies the blood flowing through the blood circuit; a blood pump provided to the arterial blood circuit; a recirculating-blood-detecting unit capable of detecting recirculating blood when the blood of the patient is caused to extracorporeally circulate through the blood circuit by activating the blood pump, the recirculating blood being blood once returned to the patient from the venous blood circuit and reintroduced into the arterial blood circuit; and a recirculation-rate-calculating unit capable of calculating recirculation rate, the recirculation rate being a proportion of the recirculating blood in the blood flowing in the arterial blood circuit. The blood purification apparatus includes a control unit capable of executing a treatment mode in which blood purification treatment is performed with the blood purifier while the blood of the patient is caused to extracorporeally circulate through the blood circuit by activating the blood pump in a state of normal connection where an upstream part of the access vessel is punctured with the puncture needle at a distal end of the arterial blood circuit and a downstream part of the access vessel is punctured with the puncture needle at a distal end of the venous blood circuit; and a measurement mode in which the detection of recirculating blood by the recirculating-blood-detecting unit and the calculation of recirculation rate by the recirculation-rate-calculating unit are performed while the blood of the patient is caused to extracorporeally circulate through the blood circuit by activating the blood pump in a state of reverse connection where the downstream part of the access vessel is punctured with the puncture needle at the distal end of the arterial blood circuit and the upstream part of the access vessel is punctured with the puncture needle at the distal end of the venous blood circuit, the calculated recirculation rate being used in calculating blood flow rate in the access vessel that is calculable in the measurement mode

A blood purification apparatus that accurately calculates the colloid osmotic pressure of a patient's blood. A dialyzer included in the blood purification apparatus has thereinside blood flow routes and dialysate flow routes that are separated from each other by hollow fibers. An ultrafiltration pump draws out water from the blood in the blood flow routes through the hollow fibers into the dialysate flow routes. Four detecting units measure the pressures of liquid flowing into the blood flow routes, the liquid discharged from the blood flow routes, dialysate flowing into the dialysate flow routes, and the dialysate discharged from the dialysate flow routes. The pressures at the four positions, the transmembrane pressure difference can be calculated. The blood flow routes are filled with a priming solution, and the transmembrane pressure difference (TMPa) is measured. Subsequently, the blood flow routes are filled with the patient's blood, and the transmembrane pressure difference (TMPb) is measured. Referencing TMPa and TMPb, the colloid osmotic pressure of the patient's blood can be calculated. Referencing colloid osmotic pressure, the plasma total protein can be calculated. Referencing plasma total protein, the patient's state of nutrition can be estimated.

A blood purification apparatus including a blood circuit including an arterial blood circuit and a venous blood circuit and that allows a patient's blood to extracorporeally circulate from a distal end of the arterial blood circuit to a distal end of the venous blood circuit; a blood purifier between the arterial blood circuit and the venous blood circuit that purifies the blood flowing through the blood circuit having a blood flow route through which the blood extracorporeally circulating through the blood circuit flows and a dialysate flow route through which dialysate flows, the blood flow route and the dialysate flow route being separated from each other by a blood purification membrane for purifying the blood; an ultrafiltration unit that performs ultrafiltration by filtering out water from the blood in the blood flow route through the blood purification membrane and draining the water through the dialysate flow route; and a substitution-fluid supply unit that supplies substitution fluid into the blood circuit. The blood purification apparatus includes a plasma-flow-rate-acquiring unit that acquires a plasma flow rate or a correlation value of plasma flow rate with reference to a blood concentration detected from the patient's blood and a plasma total protein detected from the blood flowing through the blood circuit.