An artificial lung has a gas exchanger portion with an external circulation-type gas exchanging hollow fiber membrane bundle and a heat exchanger portion with a heat exchanging element. Various design parameters of the gas exchanger and heat exchanger portions are configured to obtain a predetermined performance factor. In one embodiment, the design parameters are adjusted so that when a heat exchange performance coefficient of the artificial lung, a blood filling amount of the artificial lung, and a blood side pressure loss of the artificial lung are measured, they result in a performance factor equal to or greater than 1.5, wherein the performance factor is defined as heat exchange performance coefficient/(blood filling amountblood side pressure loss).

An artificial lung has a gas exchanger portion with an external circulation-type gas exchanging hollow fiber membrane bundle and a heat exchanger portion with a heat exchanging element. Various design parameters of the gas exchanger and heat exchanger portions are configured to obtain a predetermined performance factor. in one embodiment, the design parameters are adjusted so that when a gas exchange performance, a heat exchange performance coefficient, a blood filling amount, and a blood side pressure loss are measured, they result in a performance factor between 1.5 and 2.5, wherein the performance factor is defined as (gas exchange performanceheat exchange performance coefficient)/(blood filling amountblood side pressure loss).

A blood purifier comprises hollow fiber membranes allowing a dialysing fluid or a filtrated fluid to flow outside. The membrane has an effective length of 10 mm or more and 150 mm or less. A maximum value of a permeation flux Jv obtained by dividing a volume of a permeate fluid permeating through the membranes by a membrane area of the hollow fiber membranes and time, is represented as Jvmax. A linear velocity of blood flowing in the membrane is represented as uB. A pressure difference between blood flowing inside the membranes and a fluid flowing outside the membranes is represented as TMP. When a filling blood volume into the membranes per unit membrane area is 20 mL/m.sup.2 or more and 35 mL/m.sup.2 or less and Jvmax/uB has a value of 0.00015 or more and 0.0006 or less, a TMP change rate is 0.95 or more and 1.05 or less.

A patient fluid removal compensation volume may be determined to make up for the patient fluid removal that does not occur during machine down times, and the patient fluid removal rate may be increased until the compensating volume is satisfied.

Extracorporeal systems and methods for treating blood-borne diseases in a subject or for developing drugs to treat blood-borne diseases include various environmental and treatment modules that can be tailored to a specific disease or infection. In certain embodiments of the systems and methods, a blood sample is treated with cold plasma and optionally with hydrostatic pressure, a pulsed electrical field, a pharmaceutical agent, microwave, centrifugation, sonification, radiation, or a combination thereof, under environmental conditions that are effective for the treatment.

An extracorporeal blood cooling or heating circuit includes an intravenous catheter for withdrawing a patient's blood coupled to a combined pump/heat exchanger device. One or more sensors are provided upstream and/or downstream of the pump/heat exchanger device for measuring pressure, temperature, fluid flow, blood oxygenation, and other parameters. A controller is operatively coupled to the pump/heat exchanger device and the one or more sensors to control the speed of the pump inside the pump/heat exchanger device and regulate the blood temperature by controlling the operation of the heat exchanger. The combined pump/heat exchanger device includes a housing having at least one inlet and at least one outlet, a pump portion defining a blood circuit inside the housing, and a heat exchanger portion contained within the housing for selectively heating or cooling the blood.

A miniaturized cardiopulmonary bypass circuit for a mouse comprises at least one venous catheter connected to a patient, a dual channel peristaltic pump having one channel to move the blood by tubing from the patient, an oxygenator that removes gases from the blood and mixes the blood with fresh gases to oxygenate the blood, the blood being moved from the oxygenator to the arterial catheter by the dual channel peristaltic pump, and an arterial catheter. The blood is pumped by a two-channel roller pump into an inlet nozzle, where the flow of blood is transformed from tubular flow to planar flow. Gas exchange occurs inside the case while the blood flows down the central component. Blood then flows down the central component into the arterial reservoir. The arterial reservoir is connected to the second channel of the pump, and returned to the patient through a cannula.

The application is directed to an extracorporeal blood processing system capable of using dialysate to prime the system. A plastic molded compact manifold supports molded blood and dialysate fluidic pathways along with relevant sensors, valves and pumps. The compact manifold is also disposable in one embodiment and can be detachably installed in the dialysis machine. A two-way valve in the manifold is used to direct the dialysate flow through the blood circuit to prime the circuit for use in treatment.

An extracorporeal blood cooling or heating circuit includes an intravenous catheter for withdrawing a patients blood coupled to a combined pump/heat exchanger device. One or more sensors are provided upstream and/or downstream of the pump/heat exchanger device for measuring pressure, temperature, fluid flow, blood oxygenation, and other parameters. A controller is operatively coupled to the pump/heat exchanger device and the one or more sensors to control the speed of the pump inside the pump/heat exchanger device and regulate the blood temperature by controlling the operation of the heat exchanger. The combined pump/heat exchanger device includes a housing having at least one inlet and at least one outlet, a pump portion defining a blood circuit inside the housing, and a heat exchanger portion contained within the housing for selectively heating or cooling the blood.

A dialysis machine for extracorporeal blood therapy is configured to interface with a disposable blood line that is available in at least two different sizes. A memory in the dialysis machine is arranged to store configuration data that associates the different sizes of the blood line with a respective predefined limit value of fluid removal when the dialysis machine is operated by a controller to perform extracorporeal blood therapy. The controller is configured to execute a configuration procedure, which comprises obtaining size data indicative of a selected size of the blood line for use in the extracorporeal blood therapy in relation to a patient; determining, by use of the configuration data and based on the selected size, a maximum rate of said fluid removal from blood, and configuring the dialysis machine to maintain the fluid removal below the maximum rate during the extracorporeal blood therapy.