Medical devices and methods thereof for determining bacterial infections in blood. The medical devices and methods thereof can utilize a coating including an antibody conjugated to a reporter protein configured to indicate a bacterial infection in a patient's blood by way of an antigen thereof. Exemplary medical devices include, but are not limited to, a catheter assembly, an AV fistula needle set, an extension set for either a catheter assembly or an AV fistula needle set, and a hemodialysis tubing set. The medical devices and methods thereof can utilize immunochromatographic separation of the antibody and an antigen-antibody complex to indicate a bacterial infection in a patient's blood.

The present disclosure describes a flow reversing valve, along with associated methods and systems for providing forward flow, reverse flow, and bypass flow modes of operation, and integrating them into patient treatment systems, including those used for treating and inducing hyperthermia.

A mechanical kidney transplant designed may include a four modules designed to interconnect to clean blood. The first module may include a plurality of pump modules and a resin gel regeneration module, wherein the first module is operatively attached to a patient's iliac artery, iliac vein, and bladder. The second module may be operatively attached to the first module and may include storage and pump systems. The third module may be operatively attached to the first and fourth modules and may include a housing with ports for inflow/outflow of the blood and the physiologic resin gel between the first module and the fourth module. The fourth module may include at least one dialyzer fiber sized to accommodate a volume of blood flowing therethrough and an area surrounding the dialyzer fiber may be sized to accommodate a volume of a physiologic resin gel flowing counter current to the blood.

The invention relates to an artificial womb system for supporting newborns, in particular extremely premature infants between the 21/0 and 28/0 week of pregnancy, comprising the following: a chamber (1) of the artificial womb, said chamber being formed by an at least partially ultrasound-permeable wall (2) and comprising a lumen (14) for maintaining a physiologically intraamnial pressure and for receiving the artificial amniotic fluid (15) and a newborn or a premature infant, at least one access for supplying the premature infant in the artificial womb with nutrients, a dialysis device (9), and an oxygenator (8) and/or a gassing device for supplying oxygen to the newborn or premature infant, wherein means are provided in order to maintain an intraamnial pressure of >0 mBar in the chamber (1) of the artificial womb, said pressure acting on the newborn, in addition to the atmospheric pressure.

Described is an endovascular cannula (L1b, L2b) for defining a border of a transport volume (TrV) for an in-vivo fluid transport, the cannula (L1b, L2b) comprising:—a lumen portion (LP) that extends between a proximal end of the cannula (L1b, L2b) and a distal end of the cannula (L1b, L2b), the lumen portion (LP) defining an inner lumen, and—an expandable arrangement that has a non-expanded state and an expanded state, wherein the expandable arrangement can be switched from the non-expanded state to the expanded state, wherein in the expanded state the expandable arrangement is adapted to define at least one border of the transport volume (TrV), and wherein the border is configured to separate the transport volume from a body fluid circuit (BC).

A system configured to enclose a premature fetus within an extracorporeal environment to promote growth of the fetus and increase viability of the fetus. The system includes a chamber having an interior space configured to enclose the fetus, a first fluid circuit that delivers sterile fluid to the chamber, and a second fluid system that transfers oxygen to the fetus. The system chamber includes a stop mechanism including a clamp and an actuator, the clamp positioned in the interior space, the actuator coupled to the clamp such that movement of the actuator moves the clamp, and the actuator positioned at least partially outside the interior space.

A holder for a curved duct portion of a tube pump. The holder includes a supply-side connector which includes a first cavity and a first plate connected together, the first cavity being adapted for receiving an end of the curved duct portion, and a discharge-side connector including a second cavity and a second plate connected together, the second cavity being adapted for receiving another end of the curved duct portion, where the connectors are movable the one with respect to the other between a storage configuration, in which the supply-side connector is positioned away to the discharge-side connector, and an operating configuration, in which the supply-side connector is close to the discharge-side connector and in which the first and second plate are engaged together substantially on a same plane.

A dialysis fluid system includes a dialysis fluid inlet; a dialysis fluid outlet; a pump positioned and arranged to pump dialysis fluid through the dialysis fluid inlet and the dialysis fluid outlet; and an inductive heater located between the dialysis fluid inlet and the dialysis fluid outlet, the inductive heater including a fluid flowpath positioned and arranged to receive non-heated dialysis fluid from the dialysis fluid inlet and to output heated dialysis fluid to the a dialysis fluid outlet, a conductive heater element located within the fluid flowpath so as to be or act as a secondary coil of a transformer, and a primary coil of the transformer located outside of the fluid flowpath and positioned so as to magnetically induce a current into the conductive heater element, causing the conductive heater element and surrounding fluid to heat.

Methods and devices are disclosed that enable safe, rapid and relatively short and straight access to the cerebral arteries for the introduction of interventional devices to treat acute ischemic stroke. In addition, the disclosed methods and devices provide means to securely close the access site to the cerebral arteries to avoid the potentially devastating consequences of a transcervical hematoma.

The present disclosure pertains to control units for non-occlusive blood pumps of an extracorporeal circulatory support as well as systems comprising such a control unit and corresponding methods. Accordingly, a control unit for a non-occlusive blood pump of an extracorporeal circulatory support is configured to receive a flow value of the extracorporeal circulatory support, to receive a measurement of an arterial pressure and an ECG signal of a supported patient over a predetermined period of time, to determine a mean arterial pressure of the extracorporeal circulatory support or of the supported patient from the measurement of the arterial pressure and an energy equivalent pressure from the flow value and the arterial pressure.