Medical devices and methods thereof for determining bacterial infections in blood. The medical devices and methods thereof can utilize a coating including an antibody conjugated to a reporter protein configured to indicate a bacterial infection in a patient's blood by way of an antigen thereof. Exemplary medical devices include, but are not limited to, a catheter assembly, an AV fistula needle set, an extension set for either a catheter assembly or an AV fistula needle set, and a hemodialysis tubing set. The medical devices and methods thereof can utilize immunochromatographic separation of the antibody and an antigen-antibody complex to indicate a bacterial infection in a patient's blood.

A detector assembly configured for use in a dialysis (e.g., a hemodialysis) system is disclosed herein. The detector assembly including a wetness detector configured to detect blood, fluid, a leak, etc. The detector assembly being operatively coupled to, and more preferably, including an inertial measurement unit (IMU). Thus arranged, the detector assembly is configured to measure, read, obtain, provide, etc. additional information or data during a dialysis treatment, which information or data can be transmitted and/or used to, for example, provide greater insight into the system and/or to make better decisions. In one embodiment, the detector assembly can be used to determine when and how a patient is moving and feed that information back to the dialysis machine. In use, the information or data can be used in combination with other information to make an improved determination as to the requirement for an alert and/or stoppage of the dialysis treatment.

An embodiment provides a method for treating a body fluid of a patient with an inflammatory cytokine storm, including: removing the body fluid from a patient; applying a treatment to the body fluid, wherein the treatment comprises an antibody that joins with an antigen in the body fluid to form an antibody -antigen complex; removing the antibody-antigen complex from the body fluid; and returning the body fluid to the patient. Other aspects are described and claimed.

The present invention relates to an organizer for releasably accommodating components of blood tube sets for different extracorporeal blood treatment options, in particular for dialysis methods, by means of a blood treatment apparatus, as well as methods for manufacturing and preparing an organizer of the invention.

An optical blood monitoring system and corresponding method avoid the need to obtain a precise intensity value of the light impinging upon the measured blood layer during the analysis. The system is operated to determine at least two optical measurements through blood layers of different thickness but otherwise substantially identical systems. Due to the equivalence of the systems, the two measurements can be compared so that the bulk extinction coefficient of the blood can be calculated based only on the known blood layer thicknesses and the two measurements. Reliable measurements of various blood parameters can thereby be determined without certain calibration steps.

Apparatus and methods for providing extracorporeal blood circulation and oxygenation control include seven-stage de-airing of blood to provide automated cardiopulmonary replacement to sustain patient life during a medical procedure comprising repairing or replacing the heart valve in a patient.

A tubing set suitable for use in co-operation with a hemodialysis machine includes an out-tube for supplying the blood from the patient to a filter of the machine, an in-tube for supplying the blood from the filter back to the patient, a drip chamber placed along one of the tubes, adapted to let the blood drip through an air buffer, and a vial gate for the connection of vials containing drugs to be delivered into the blood. The vial gate includes a delivery lumen, suitable for delivering the drug from the vial to the drip chamber, and a vent lumen, suitable for providing air inside the vial in order to replace the delivered drug.

A load suspension and weighing system for a removable reservoir unit of a portable dialysis machine includes a centrally located flexure assembly. The flexure assembly includes magnets and a number of flexure rings which allow for movement of the magnets about a fixed circuit board. Sensors in the circuit board sense changes in the magnetic field as the magnets move in relation to the circuit board. The magnetic field changes produce a voltage output which is used by a processor to generate weight calculations. The top of the flexure assembly is attached to the interior of the dialysis machine. The entirety of the reservoir unit is suspended by a first internal frame that is attached to the bottom of the flexure assembly. Having a single flexure assembly positioned above the reservoir unit provides more accurate weight measurements while also preventing damage to the assembly from water spillage.

A method for filling and venting a device for extracorporeal blood treatment is disclosed, such as a patient module in a heart-lung machine, without attached patient. A filling liquid from a filling liquid container located higher than the device flows by gravity via a venous side of the system into a reservoir and flows onwards into a blood pump located at the lower end of the reservoir, wherein a first controllable valve (HC1) for a venting line of a filter is opened and, after the response of an upper filling level sensor in the reservoir, is closed. An upper level of the filter is positioned higher than the upper filling level sensor, and a start-stop motion of the blood pump is performed, as a result of which a stepped flooding of the filter is made providing for an advantageous de-airing of the device.

The present invention concerns a package comprising an acidic citrate containing concentrate, an acidic citrate containing concentrate (or acidic citrate containing solution), and a system wherein the acidic citrate containing concentrate is included for providing a dialysis treatment. The acidic citrate containing concentrate contains citric acid and citrate in a molar ratio of 75:25 to 85:15, and has a pH of between 2 and 3.