The present invention relates to an apparatus comprising at least one multi-lumen tube, wherein the tube has a first group of lumens and a second group of lumens wherein the lumens of the second group are arranged around the lumen(s) of the first group, and wherein the lumen(s) of the first group serve the transportation of at least one first fluid, and wherein the lumens of the second group are filled with at least one functional fluid, wherein the apparatus furthermore comprises at least one actuator which is in communication with at least one of the second lumens and is configured such that at least one property of the functional fluid can be changed by means of the actuator.

The invention relates to a treatment device (100) which is designed for extracorporeal blood treatment of blood of a subject (2) for an immunotolerance enhancement of the subject (2), comprising at least one container (10) which has an interior (11) for receiving a blood sample (1) of blood of the subject (2) and an exchange device (20) designed to supply and/or discharge the blood sample (1) into or out of the interior (11) of the container (10) and comprising a cell exposure device (30) which is positioned in the container (10) and has biological cell material (31) with surface molecules, said cell material being arranged in the interior (11) of the container (10) for a material interaction with the blood sample (1), including a reaction of endogenous immune cells in the blood with the surface molecules of the cell material. The invention also relates to a kit for extracorporeal blood treatment and to a method for operating the treatment device.

A system for controlling a fluid procedure comprising a reusable separation apparatus controlled by a microprocessing controller. A sterile circuit is configured to associate with the reusable separation apparatus and provide a first fluid flow path in association with a pressure sensor in communication with the controller and a first pump configured to transmit pulsatile pressure signals to the pressure sensor during operation in association with the first fluid flow path. The reusable apparatus and the controller are configured to receive from the pressure sensor pressure signals comprising the pulsatile pressure signals, perform a frequency analysis of the pressure signals received by the pressure sensor over a time duration, derive a first rotation rate of the first pump or a first fluid flow rate at the first pump from the frequency analysis, and provide a response action based on the first rotation rate or the first fluid flow rate.

This disclosure relates to a blood treatment system including a blood treatment machine, a dialyzer configured to be coupled to the blood treatment machine, a blood line having a first end configured to be connected to the dialyzer and a second end configured to be connected to a needle for insertion into a patient, and one or more sensors operable to transmit, to the blood treatment machine, data related to tension along the blood line. The blood treatment machine is configured to take action in response to the data received from the one or more sensors.

An extracorporeal blood treatment device and a method for automatic priming of an extracorporeal blood treatment device. The device includes an extracorporeal circuit, a dialyser, a dialysis liquid circuit and a control unit. The control unit is designed to control the priming such that a liquid is delivered from the dialysis liquid circuit via a membrane of the dialyser to the extracorporeal circuit, and to actuate valves and/or pumps in the dialysis liquid circuit such that pressure builds up in the dialyser on the dialysis liquid side. The control unit actuates a flow machine in the extracorporeal circuit to perform a push cycle, in which the flow machine pushes air into the extracorporeal circuit, and a pull cycle, in which the flow machine draws air out from the extracorporeal circuit, to assist a transfer of the liquid through the membrane of the dialyser during the priming process.

The present invention generally relates to hemodialysis and similar dialysis systems, including a variety of systems and methods that would make hemodialysis more efficient, easier, and/or more affordable. One aspect of the invention is generally directed to new fluid circuits for fluid flow. In one set of embodiments, a hemodialysis system may include a blood flow path and a dialysate flow path, where the dialysate flow path includes one or more of a balancing circuit, a mixing circuit, and/or a directing circuit. Preparation of dialysate by the preparation circuit, in some instances, may be decoupled from patient dialysis. In some cases, the circuits are defined, at least partially, within one or more cassettes, optionally interconnected with conduits, pumps, or the like. In one embodiment, the fluid circuit and/or the various fluid flow paths may be at least partially isolated, spatially and/or thermally, from electrical components of the hemodialysis system. In some cases, a gas supply may be provided in fluid communication with the dialysate flow path and/or the dialyzer that, when activated, is able to urge dialysate to pass through the dialyzer and urge blood in the blood flow path back to the patient. Such a system may be useful, for example, in certain emergency situations (e.g., a power failure) where it is desirable to return as much blood to the patient as possible. The hemodialysis system may also include, in another aspect of the invention, one or more fluid handling devices, such as pumps, valves, mixers, or the like, which can be actuated using a control fluid, such as air. In some cases, the control fluid may be delivered to the fluid handling devices using an external pump or other device, which may be detachable in certain instances. In one embodiment, one or more of the fluid handling devices may be generally rigid (e.g., having a spheroid shape), optionally with a diaphragm contained within the device, dividing it into first and second compartments.

The present disclosure relates to an effluent bag for collecting accumulated blood treatment effluent. The effluent bag comprises a closeable effluent opening or connection to an exterior of the effluent bag. The disclosure further relates to methods, a blood treatment apparatus, and a discharge hose system.

Methods and systems for bidirectional priming of a blood circuit while a catheter is connected to the circuit that delivers gas-enriched blood to a patient. The system primes the circuit while the catheter is connected to the circuit by controlling a first flow control mechanism to close to prevent blood flow through the draw line to a catheter and causes a pump to circulate blood in a first direction through a mixing chamber and/or through a bubble trap that removes air bubbles from the circuit. The system controls a second flow control mechanism to close to prevent blood flow in a return line to the catheter while causing the first flow control mechanism to open after the second flow control mechanism is closed and while causing the pump to circulate the blood in a second, opposite direction through the mixing chamber that removes air bubbles from the circuit.

Embodiments herein relate to medical devices and methods for monitoring and/or treatment including the use of synthetic polymers exhibiting specific binding for compounds such as disease state markers or toxic substances. In an embodiment, a method of testing a patient for a disease state is included, the method can include withdrawing a fluid sample from the patient and contacting the fluid sample with an extracorporeal monitoring device. The extracorporeal monitoring device can include a microporous membrane. The microporous membrane can include a synthetic polymer, wherein the synthetic polymer exhibits binding specificity with a disease state marker. The method can further include evaluating the extracorporeal monitoring device for the presence of the disease state marker. Other embodiments are included herein.

A monitoring device of a dialysis machine and a method for detecting a venous needle disconnection via venous pressure monitoring based on a threshold value setting. The device includes a button, preferably arranged on a screen of the dialysis machine. The button is configured, upon actuation, to set a lower threshold value and an upper threshold value depending on an actual pressure and to detect an incremental decrease in the venous pressure.