A tubing set suitable for use in co-operation with a hemodialysis machine includes an out-tube for supplying the blood from the patient to a filter of the machine, an in-tube for supplying the blood from the filter back to the patient, a drip chamber placed along one of the tubes, adapted to let the blood drip through an air buffer, and a vial gate for the connection of vials containing drugs to be delivered into the blood. The vial gate includes a delivery lumen, suitable for delivering the drug from the vial to the drip chamber, and a vent lumen, suitable for providing air inside the vial in order to replace the delivered drug.

Simple-to-use systems, methods, and devices for priming replacement blood treatment devices, for swapping the blood treatment devices out, for replacing swapped-out blood treatment devices, and other related operations are described. In embodiments, a blood treatment device can be primed while a therapy is still running. When the replacement blood treatment device is needed, the therapy can be stopped momentarily (less than a minute) for the rapid and safe swap of the blood treatment device. Blood loss can be minimized. The down time from therapy can be minimized.

The invention relates to generally to a vascular access graft that includes a magnetic element disposed about a flow tube for guiding a blood flow between an arterial end adapted for arterial anastomosis to a portion of an artery, and a venous end adapted for venous anastomosis to a portion of a vein. The magnetic element may include a plurality of magnets disposed about the flow tube so that a magnetic field may be applied to blood flowing therein; the magnetic element may alternatively include a circuitry configured to generate a magnetic field applied to the flow tube.

The present invention concerns an extracorporeal circuit for regional scoagulation of blood comprising a line for taking the blood from the patient, a first filtering unit, and a line for returning the blood to the patient defining a main circuit, the extracorporeal circuit comprising a secondary circuit for recirculation of the plasma water comprising: a calcium removal assembly adapted to provide a solution with low calcium content in said main circuit;
the extracorporeal circuit further comprising: first means for the infusion of said solution with low calcium content into said main circuit upstream of said first filtering unit and of said calcium removal assembly with respect to the blood flow direction in the main circuit and second means for the infusion of an electrolytic re-establishment solution located downstream of said first means with respect to the direction of the blood flow in said main circuit.

The present invention concerns a package comprising an acidic citrate containing concentrate, an acidic citrate containing concentrate (or acidic citrate containing solution), and a system wherein the acidic citrate containing concentrate is included for providing a dialysis treatment. The acidic citrate containing concentrate contains citric acid and citrate in a molar ratio of 75:25 to 85:15, and has a pH of between 2 and 3.

A method of collecting plasma includes receiving donor parameters at a controller of a plasma collection device electronically from a donor management system. The method includes storing a target volume for raw plasma which is based at least in part on donor height and weight used to calculate total donor blood volume, the target volume for raw plasma based on the total donor blood volume. The method includes setting the target volume for raw plasma and controlling the plasma collection device to operate draw and return phases to withdraw whole blood from a donor and separate the whole blood into the plasma product and a second blood component comprising red blood cells and to return the second blood component to the donor. The controller operates the draw and return phases until a volume of raw plasma in the collection container equals the target volume of raw plasma.

A system, method or apparatus to detect abnormalities in delivery of a fluid may include an infusion apparatus that is controllable to cause one or more perturbations in a fluid flow (e.g., each of the one or more perturbations in the fluid flow may result in a measurable perturbed force response). A force signal representative of the perturbed force response may be used to determine an integrated perturbed force response value (e.g., using integration of the force signal over a perturbation time period; the integrated perturbed force response value being representative of an additional force caused by the at least one perturbation over an equilibrium force). A ratio between the integrated perturbed force response value and a normalizing value (e.g., based at least on a maximum perturbation force of the perturbed force response) may be used to determine if fluid flow is occluded.

A system is provided for separating a plasma-containing fluid into separated plasma and a concentrated fluid. The system cooperates with a fluid flow circuit including a fluid separation chamber and a plasma outlet line associated therewith for removing separated plasma from the fluid separation chamber. The system includes an optical sensor assembly to monitor the contents of the plasma outlet line and produce an output indicative of the concentration of free plasma hemoglobin in the plasma outlet line. A controller of the system calculates the amount of free plasma hemoglobin in at least a portion of the concentrated fluid based at least in part on the output of the optical sensor assembly. The controller may periodically calibrate the optical sensor assembly by determining an instrument-specific correlation between optic output and free hemoglobin concentration and comparing it to experimentally determined data to ensure continued reliability of the optical sensor assembly.

A medical fluid management assembly includes a pneumatic manifold, a pump and valve engine, and a fluid manifold. The pneumatic manifold includes a plurality of pneumatic passageways and a plurality of pneumatic connectors. The pump and valve engine includes a plurality of valve chambers, at least one pump chamber, and a plurality of pneumatic connectors mated sealingly and releasably with the pneumatic connectors of the pneumatic manifold. The pump and valve engine also includes a plurality of fluid connectors. The fluid manifold includes a plurality of fluid pathways and a plurality of fluid connectors mated sealingly and releasably with the fluid connectors of the pump and valve engine.

A microfluidic photoreactor for treating excess bilirubin in blood, having: a microfluidic channel module; an illumination module comprising one or more illumination sources disposed about the microfluidic channel module and configured to illuminate blood passing through at least one microfluidic channel of the microfluidic channel module; and a heat exchanger module coupled to the at least one microfluidic channel module, wherein the heat exchanger module is configured to extract heat from the at least one microfluidic channel. A system including a microfluidic photoreactor and a method of treating excess bilirubin in blood.