An aspiration system comprises an aspiration catheter, an aspiration source fluidly coupled to the aspiration catheter to create an aspiration flow path between the aspiration catheter and the aspiration source, a pressurized fluid source, and a passive pressure oscillation assembly fluidly coupled between the pressurized fluid source and the aspiration flow path. The passive pressure oscillation assembly is configured for being operated between a normal mode that prevents fluid communication between the pressurized fluid source and the aspiration flow path, and an oscillatory mode that pulses fluid communication between the pressurized fluid source and the aspiration flow path. The passive pressure oscillation assembly is configured for being triggered to switch from the normal mode to the oscillatory mode in response to a clog in the aspiration catheter.

An adapter for an evacuator for increasing a suction power of the evacuator includes a suction assembly adapted to be coupled with the evacuator. The suction assembly has a housing, an impeller arranged inside the housing and configured to provide a suction, and an inlet conduit to facilitate a flow of fluid to the impeller. The suction assembly also includes an outlet conduit arranged inside the housing and adapted to be coupled to the evacuator. The outlet conduit is in fluid communication with the impeller and facilitates a flow of the fluid from the suction assembly to the evacuator.

A system for aspirating thrombus including an aspiration catheter having a supply lumen, an aspiration lumen, and a first connector hydraulically coupled to the proximal end of the aspiration lumen, and a pressure sensor having an internal passageway and having a distal connector configured to hydraulically couple to the first connector, a proximal connector configured to couple to a vacuum source, and a valve disposed between the distal connector and the proximal connector, the valve having an open state and a closed state.

An adapter for an evacuator for increasing a suction power of the evacuator includes a suction assembly adapted to be coupled with the evacuator. The suction assembly has a housing, an impeller arranged inside the housing and configured to provide a suction, and an inlet conduit to facilitate a flow of fluid to the impeller. The suction assembly also includes an outlet conduit arranged inside the housing and adapted to be coupled to the evacuator. The outlet conduit is in fluid communication with the impeller and facilitates a flow of the fluid from the suction assembly to the evacuator.

A system for aspiration includes an aspiration catheter including an elongate shaft including an aspiration lumen, and an open distal end, an extension tube, the lumen of the extension tube configured to be hydraulically coupled to the aspiration lumen, a peristaltic pump configured for driving fluid through the extension tube, a compressible portion disposed between the distal end and the proximal end of the extension tube, the compressible portion configured to be coupled to the peristaltic pump, such that operation of the peristaltic pump drives fluid from the aspiration lumen from the distal end of the extension tube to the proximal end of the extension tube, and a controller configured to receive a first signal from the first sensor and configured to vary the operation of the peristaltic pump based at least in part on a first signal received from a first sensor coupled to the aspiration lumen or extension tube related to a change in the characteristic of flow.

A system for aspirating thrombus includes an aspiration catheter including a supply lumen and an aspiration lumen each extending within an elongate shaft, and an opening at or near the distal end of the supply lumen, the opening configured to allow the injection of pressurized fluid into the aspiration lumen at or near the distal end of the aspiration lumen when the pressurized fluid is pumped through the supply lumen, a tubing set including tubing and having a distal end configured to couple to the aspiration lumen of the aspiration catheter and a proximal end configured to couple to a vacuum source, a tubing compression element configured to externally engage the tubing of the tubing set, and an activation interface configured to activate the tubing compression element to compress the tubing at a location between the proximal end of the tubing set and the distal end of the tubing set.

A system for aspirating thrombus including an aspiration catheter including a supply lumen and an aspiration lumen, the supply lumen having a proximal end and a distal end, the aspiration lumen having a proximal end and an open distal end. An opening at or adjacent the distal end of the supply lumen, in fluid communication with the interior of the aspiration lumen, is located proximally of the open distal end of the aspiration lumen. The opening is configured to create a jet when pressurized fluid is pumped through the supply lumen. A connector is hydraulically coupled to the proximal end of the aspiration lumen, the connector having an interior cavity, a proximal end and a distal end.

A method for removing thrombus from a patient, the method including providing an aspiration catheter having a supply lumen, an aspiration lumen, an opening at or adjacent a distal end of the supply lumen, and a connector hydraulically coupled to the aspiration lumen, the connector having an interior cavity. The method includes placing the aspiration catheter through an inner lumen of a guiding catheter and into the blood vessel, coupling the aspiration catheter to a fluid source and a vacuum source, causing an injection of fluid from the fluid source through the supply lumen via a first pump with the vacuum source actively coupled to the aspiration lumen, and determining that aspiration of the thrombus through the aspiration lumen is not occurring at a desired thrombus aspiration rate.

A system for aspirating thrombus including an aspiration catheter including a supply lumen, an aspiration lumen, an opening at or adjacent a distal end of the supply lumen, in fluid communication with an interior of the aspiration lumen, the opening located proximally of an open distal end of the aspiration lumen. The opening is configured to create a jet when pressurized fluid is pumped through the supply lumen. A connector is hydraulically coupled to the aspiration lumen, the connector having an interior cavity having an inner surface, a proximal end and a distal end, wherein the connector includes a first sideport communicating with the interior cavity of the connector and in fluid communication with the aspiration lumen, and wherein the first sideport includes the nearest significant interruption of the inner surface to the distal end of the connector.

A first connector configured for removable connection proximal to an aspiration catheter, the first connector comprising a body having an interior, a distal end comprising a connection configured to sealably couple to a aspiration lumen of the aspiration catheter, a proximal end comprising an openable and closable seal configured for sealing over a guidewire, an aspiration port in fluid communication with an interior of the body and configured to couple to a vacuum source, and a pressure sensor in fluid communication with the interior of the body.