Some embodiments provide in-line negative pressure wound therapy (NPWT) sampling assessment systems, comprising: a housing; a wound fluid input port configured to fluidly couple with a first wound fluid lumen extending from a wound treatment site; a wound fluid output port configured to fluidly couple with a NPWT control unit; an in-line sampling chamber positioned within the housing and comprising a theranostic sampling element, wherein the first in-line sampling chamber is configured to: removably and fluidly couple between the input port and the output port in-line with a wound fluid path between the wound treatment site and the NPWT control unit with the first theranostic sampling element positioned so that at least some of the wound fluid contacts at least a portion of the first theranostic sampling element; and decouple out of the wound fluid path without interrupting a negative pressure treatment process applied at the wound treatment site.

Provided are drainage systems that may include a drainage manifold and may be suitable for draining fluid from a tissue site. The drainage manifold may include a plurality of elongate members having a moveable end that may be adapted to configure the drainage manifold to treat a uniquely shaped tissue site. The drainage manifold may be coupled to a drainage tube with a transitional connector to provide a drainage system capable of distributing reduced pressure to the tissue site to enhance the drainage of fluids.

Disclosed herein are systems and methods for providing reduced or negative pressure, and more particularly cyclical reduced pressure, to treat a wound. The system can include a wound dressing, a fluid collection container, a suction source, filters, and conduits. In addition, the system can include a control device and sensors. The sensors may be configured to monitor certain physiological conditions of a patient such as temperature, pressure, blood flow, blood oxygen saturation, pulse, cardiac cycle, and the like. Application of cyclical reduced pressure between two or more values below atmospheric pressure may be synchronized with the physiological conditions monitored by the sensors. Certain embodiments of the system utilize an air reservoir and one or more valves and pressure sensors or gauges to allow for rapid cycling of the level of reduced pressure within the wound dressing between two or more reduced pressure values.

Provided are drainage systems that may include a drainage manifold and may be suitable for draining fluid from a tissue site. The drainage manifold may include a plurality of elongate members having a moveable end that may be adapted to configure the drainage manifold to treat a uniquely shaped tissue site. The drainage manifold may be coupled to a drainage tube with a transitional connector to provide a drainage system capable of distributing reduced pressure to the tissue site to enhance the drainage of fluids.

Embodiments of tissue monitoring in combination with negative pressure wound therapy systems and methods are disclosed. In some embodiments, a monitoring and therapy system comprises collecting video images of a tissue site and amplifying said video images via Eulerian Video Magnification. Depending upon the changes detected via Eulerian Video magnification, negative pressure wound therapy may be delivered to the tissue site, stopped, or altered in some manner.

A pump generates a vacuum at a wound site via first tubing. A negative pressure circuit is defined by a canister, the first tubing and the wound site. A controller of a therapy device operates the pump to apply a first negative pressure to the entirety of the negative pressure circuit, following which ambient air is allowed to flow into the negative pressure circuit. The controller also operates the pump to apply a second negative pressure to a selected portion of the negative pressure circuit exclusive of the wound site, following which ambient air is allowed to flow into the selected portion. A quantity of fluid to be delivered to the wound site via a second tubing is determined by comparing measured parameters related to the flow of air into the negative pressure circuit to parameters measured with respect to the flow of air into the selected portion.

Provided are drainage systems that may include a drainage manifold and may be suitable for draining fluid from a tissue site. The drainage manifold may include a plurality of elongate members having a moveable end that may be adapted to configure the drainage manifold to treat a uniquely shaped tissue site. The drainage manifold may be coupled to a drainage tube with a transitional connector to provide a drainage system capable of distributing reduced pressure to the tissue site to enhance the drainage of fluids.

Disclosed herein are systems and methods for providing reduced or negative pressure, and more particularly cyclical reduced pressure, to treat a wound. The system can include a wound dressing, a fluid collection container, a suction source, filters, and conduits. In addition, the system can include a control device and sensors. The sensors may be configured to monitor certain physiological conditions of a patient such as temperature, pressure, blood flow, blood oxygen saturation, pulse, cardiac cycle, and the like. Application of cyclical reduced pressure between two or more values below atmospheric pressure may be synchronized with the physiological conditions monitored by the sensors. Certain embodiments of the system utilize an air reservoir and one or more valves and pressure sensors or gauges to allow for rapid cycling of the level of reduced pressure within the wound dressing between two or more reduced pressure values.

Systems and methods for component stress relief are disclosed. In some embodiments, a wound dressing includes a substantially stretchable wound contact layer including a wound facing side and a non-wound facing side. The wound facing side or the non-wound facing side of the wound contact layer can support a plurality of electronic components and a plurality of electronic connections that connect at least some of the plurality of the electronic components. The wound facing side or the non-wound facing side of the wound contact layer can include a region of substantially non-stretchable material that supports at least one electronic component from the plurality of electronic components. The at least one electronic component can be attached to the wound contact layer with adhesive material. Such arrangement can securely position the at least one electronic component and limit the mechanical strain on the at least one electronic component supported by the region.

A sensor sheet of a wound monitoring and/or therapy apparatus can include one or more electrical connections. The electrical connections can include multiple conductive inks having different impedances. A track of first conductive ink having a first impedance can be coupled to an electrical connector of an electronic component. A track of second conductive ink having a second impedance can be coupled to the track of first conductive ink.