A wound therapy system includes a first sensor assembly, a second sensor assembly, and a processing circuit. The first sensor assembly is configured to be located at a wound treatment site on a patients body and to record physical characteristics representative of periwound tissue at the wound treatment site. The second sensor assembly is configured to be located at a healthy tissue site on the patients body contralateral to the wound treatment site and to record one or more physical characteristics representative of healthy tissue at the healthy tissue site. The physical characteristics representative of the healthy tissue are recorded concurrently with the physical characteristics representative of the periwound tissue. The processing circuit is configured to receive the one or more physical characteristics representative of the periwound tissue from the first sensor assembly at the wound treatment site, receive the one or more physical characteristics representative of the healthy tissue from the second sensor assembly at the healthy tissue site, and determine a healing progression of the wound based on a difference between the one or more physical characteristics representative of the periwound tissue and the one or more physical characteristics representative of the healthy tissue.

A wound therapy system includes an instillation fluid canister configured to contain an instillation fluid, a pump fluidly coupled to the instillation fluid canister and operable to deliver the instillation fluid from the instillation fluid canister to a wound, a user interface configured to receive user input indicating one or more geometric attributes of the wound, and a controller electronically coupled to the pump and the user interface. The controller is configured to determine a volume of the wound based on the user input, determine a volume of the instillation fluid to deliver to the wound based on the volume of the wound, and operate the pump to deliver the determined volume of the instillation fluid to the wound.

A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.

In-vivo systems and methods for the detection of early signs of post-surgery infection are described. The in-vivo systems include a drain system with a tube configured to drain fluids from a surgery site, at least one sensor unit for sensing the presence of at least one infection biomarker, a processor for processing a signal generated by the at least one sensor unit, a transmitter for transmitting the signal, and a notification system for receiving the signal, analyzing the signal by comparing it to a threshold, determining presence of infection, and generating an indication on the presence of infection.

In some examples, a system for treating a tissue site may include a dressing, at least one fluid sampling conduit, and at least one fluid sampling assembly. The dressing may be configured to be positioned at the tissue site. The at least one fluid sampling assembly may be configured to be in fluid communication with the tissue site through the at least one fluid sampling conduit. The at least one fluid sampling assembly may include a fluid vessel for receiving a fluid from the tissue site. The fluid may be a sampling fluid communicated directly from the tissue site and representative of the physiological condition of the tissue site. Other devices, systems, and methods are disclosed.

An apparatus for use in treating a tissue site with negative pressure, which may comprise a fluid path between a first end and a second end. The fluid conductor may additionally comprise a plurality of pressure indicators configured to indicate a pressure state between the first end and the second end. In some examples, the fluid conductor may be fluidly coupled to a source of negative pressure and a dressing, which can be configured to be applied to a tissue site for treatment with negative pressure.

A system for applying reduced pressure to tissue includes a multi-lumen reduced pressure delivery tube having a proximate end, a distal end, a primary lumen extending through the conduit from the proximate end to the distal end, and an ancillary lumen extending through the conduit from the proximate end to the distal end. A vacuum pump is coupled to the proximate end of the primary lumen, and a reduced pressure adapter is coupled to the distal end of the reduced pressure delivery tube. The adapter includes channels to direct liquid away from the ancillary lumens and into the primary lumen.

A system for applying reduced pressure to tissue includes a multi-lumen reduced pressure delivery tube having a proximate end, a distal end, a primary lumen extending through the conduit from the proximate end to the distal end, and an ancillary lumen extending through the conduit from the proximate end to the distal end. A vacuum pump is coupled to the proximate end of the primary lumen, and a reduced pressure adapter is coupled to the distal end of the reduced pressure delivery tube. The adapter includes channels to direct liquid away from the ancillary lumens and into the primary lumen.

Embodiments of negative pressure wound therapy systems, apparatuses, and methods for operating the systems and apparatuses are disclosed. In some embodiments, a medical device is configured to detect an identity of a patient-contacting disposable connected to the medical device. The medical device automatically modifies one or more operational parameters of the medical device based on the identity of the patient-contacting disposable connected to the medical device. The medical device can include a user interface and modify automatically available selections in the user interface based on the identity of the patient-contacting disposable connected to the medical device.

An assembly includes a drape substantially sealable over a wound bed and a trackpad configured to couple a tube to the drape and allow the tube to provide suction to the wound bed. The assembly also includes a vent opening in the drape, a filter coupled to the drape and communicating with the vent opening, a cover coupled to the drape and movable between a first position to cover the vent opening and filter and a second position to uncover the vent opening and the filter, and a fluid indicator coupled to the drape and operable to provide a visual indication that fluid build-up is present in the wound bed.