Low-profile fluid injection systems and methods for injecting fluid into a tumor within a body comprising an elongate member, a plurality of fluid delivery members, and a plurality of fluid reservoirs. Each of the plurality of fluid reservoirs may be fluidly coupled to a single of fluid delivery lumen of a single fluid delivery member such that each of the fluid delivery members is fluidly independent of every other fluid delivery member. The plurality of fluid delivery members may be configured to extend out of a distal end of the elongate member into the tumor when the system is positioned in the body of a patient. A fluid delivery mechanism may be operably coupled to the plurality of fluid reservoirs in order to deliver fluids from the plurality of fluid reservoirs to the plurality of fluid delivery members and inject the fluids into the tumor.

A drug delivery device (100) for administering a low dose of a medicament includes a housing (111) and a drug reservoir (101) disposed in the housing (111). A needle (135) is connected to the drug reservoir (101). A pressure applying member (113) is movably connected to the housing (111) and is movable between first and second positions. The pressure applying member (113) does not apply pressure to the drug reservoir (101) in the first position and applies pressure to the drug reservoir (101) in the second position to dispense medicament stored in the drug reservoir (101). A method of administering a low dose of insulin to simulate a first-phase insulin response of a pancreas is also disclosed.

A wearable medication injecting device which is worn on a patient's body and adapted to automatically administer medication to the patient via a scheduled injection, the device comprising a detachable medication module containing the medication and a needle, a medication injection assembly having a mounting plate with at least one attachment point for removably engaging the detachable medication module, and a band which secures the mounting plate against the patient's skin surface. The needle is adapted to pass through the mounting plate to penetrate the skin surface and deliver the medication. Replacing the detachable medication module both replenishes the medication and replaces the needle, and attaching additional detachable medication modules allows a second medication to be simultaneously administered. A user control device is adapted to wirelessly communicate with the medication injection assembly to control the scheduled injections and convey device status alerts to a user.

Apparatus and methods for inserting a medicament into a body cavity are described. The apparatus comprises an elongate tube with a plunger rod therein. The plunger rod has at least one projection which cooperatively interacts or engages with at least one discontinuity on the inside of the elongate tube so that proximal movement of the plunger rod with respect to the elongate tube expels the medicament into the body cavity.

Medical devices for delivering compositions or medical articles to a patient are disclosed. The medical plug delivery devices can include a fluid delivery device (e.g., a syringe), a frame, and a rotatable magazine. The rotatable magazine can include a plurality of chambers that each hold a composition or a medical article (e.g., a medical plug). By rotating the rotatable magazine relative to the frame, material within the chambers of the rotatable magazine can be sequentially deployed to a patient.

A delivery device for delivering a gel or liquid pharmaceutical to a treatment site, the delivery device including a body extending from a delivery tip, the body defining a cavity for retaining a pharmaceutical or a pre-assembled cartridge holding the pharmaceutical; and a driver for mechanically discharging the pharmaceutical from the cartridge to the delivery tip. The driver may be adapted to release a consistent flow of the pharmaceutical. In addition, the delivery device may be biased into a release configuration.

A drug delivery device (100) for administering a low dose of a medicament includes a housing (111) and a drug reservoir (101) disposed in the housing (111). A needle (135) is connected to the drug reservoir (101). A pressure applying member (113) is movably connected to the housing (111) and is movable between first and second positions. The pressure applying member (113) does not apply pressure to the drug reservoir (101) in the first position and applies pressure to the drug reservoir (101) in the second position to dispense medicament stored in the drug reservoir (101). A method of administering a low dose of insulin to simulate a first-phase insulin response of a pancreas is also disclosed.

A recharging and medication storage hub for a re-usable drug-delivery device is provided. According to some embodiments, the hub comprises a housing defining a port sized to receive at least part of the re-usable drug-delivery device, a charging station disposed on the housing configured to charge a rechargeable power source mounted on the drug-delivery device, and a medication storage chamber disposed in alignment with the port, the storage chamber configured to store a single-use medication cartridge. When at least part of the drug-delivery device is inserted through the port and into the medication storage chamber, a coupling mechanism is configured to releasably couple with and withdraw the medication cartridge from the medication storage chamber. In some embodiments, the hub may further comprise a temperature-changing device configured to control an interior temperature of the medication storage chamber.

A device for implanting a substance into subcutaneous tissue or the dermis of a patient can include a housing, a hypodermic needle, a rod, and a bolt-action rod displacement mechanism. The hypodermic needle can include a lumen that is preloaded with a dermal filler thread. The rod can be configured to fit within the lumen of the hypodermic needle. Upon displacement within the lumen, the rod can cause displacement of the dermal filler thread within the lumen. The bolt-action rod displacement mechanism can be configured to displace the rod within the lumen away from a starting position toward the dermal filler thread.

A substance delivery device that includes a hypodermic needle with a tube for receiving and containing a volume of a substance. The substance delivery device includes a rod, a portion of which is of a size and shape to fit within the tube of the hypodermic needle. The rod can be displaced into and within the tube to contact and apply a force to a volume of substance contained within the tube to cause, at least in part, the volume of substance to be discharged out of the tube. The substance delivery device includes a rod displacement mechanism that applies a force to the rod to cause the rod to be displaced into and within the tube. The substance delivery device also includes a needle retraction mechanism that is configured to apply a force to the hypodermic needle to cause the hypodermic needle to retract from within a patient.