Disclosed herein are systems comprising a pressure adjustment manifold, a pressure distribution manifold, and an electronic board, each of which are operatively connected. Also provided herein are methods of making and using the same.

The present invention relates to an apparatus for controlling microorganism load on or near a medical infusion line. The apparatus comprises an electronic illuminator, including a light emitting diode (LED) that emits light radiation at a wavelength of 100 nm to 400 nm, and a lens for directing light from the LED. Additionally, a side emitting fiber optic line, equipped with a protective end cap, is attached to the electronic illuminator at the lens. The side emitting fiber optic line is configured to the medical infusion line. This apparatus effectively controls the microorganism load by emitting light radiation in the specified wavelength range, thereby reducing the risk of contamination and infection in medical infusion procedures.

An integrated skin patch artificial pancreas includes an infusion mechanism module, including a case, provided with multiple second electrical contacts exposed on the case and multiple second engaging portions; a control mechanism module, provided with multiple first electrical contacts exposed on the surface of the control mechanism module and multiple first engaging portions, the control mechanism module including an input end and an output end, and the input end including electrically connective regions for receiving signals of analyte data in the body fluid and an infusion tube (150), provided with multiple electrodes.

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade within the wall to release the drug to produce a therapeutic effect. The preparation can be coupled to an actuator having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

Disclosed herein is a system and method for calculating an expected peak blood glucose level of user during a post-prandial period, based on a quantity of carbohydrates to be ingested. The user's expected peak blood glucose levels for slow, medium and fast acting carbohydrates are calculated. The results are presented to the user to allow the user to make an informed decision regarding the type of meal to be ingested.

A skin patch drug infusion device is disclosed. The skin patch drug infusion device includes an infusion mechanism module, the infusion mechanism module includes an infusion module and a circuit module, the circuit module includes: a circuit board or a three-dimensional circuit coated on the surface of part components, for supplying power to specific units; a power supply, for supplying power to the infusion device; an elastic conductor, provided with at least a protrusion, for electrically connecting the power supply to the specific connection end on the circuit board or three-dimensional circuit; a control mechanism module, electrically connected with the infusion mechanism module; and an adhesive patch, for attaching the infusion mechanism module and the control mechanism module to the skin surface. The elastic conductor is provided with protrusions.

Invasive glucose sensors and noninvasive glucose sensors may be used in conjunction to improve glucose management for a user. The rate of change (ROC) of glucose levels from a noninvasive glucose sensor may be used rather than or in conjunction with a glucose level of the user from a CGM. A basal insulin delivery rate to the user may be adjusted responsive to the ROC glucose level data from the noninvasive sensor. The glucose level ROC from a noninvasive glucose sensor may be used to predict future glucose level ROCs of the user between operational cycles of an insulin delivery device and/or to identify possible hypoglycemic or hyperglycemic events. These predicted future glucose level ROCs may be used in a cost function of the control system of the insulin delivery device to select basal insulin delivery doses. Glucose level readings may be used to calibrate a noninvasive glucose level sensor.

A monitor for measuring the flow rate of a fluid medicament is incorporated into an elastomeric tube that will be used to transfer fluid medicament from a supply source to the patient. Structurally, the monitor includes a hollow shell having a flexible membrane that is affixed across the inside the shell to create a fluid tight barrier which bifurcates the shell's interior into a gas enclosure and a liquid pathway. As fluid passes through the liquid pathway from the supply source and on to the patient, movements of the flexible membrane cyclically indicate changes in the volume of the gas enclosure. Volume changes of the gas enclosure are measured by a pressure gage to indicate the flow rate of the fluid medicament.

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade within the wall to release the drug to produce a therapeutic effect. The preparation can be coupled to an actuator having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Some embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. The device comprises a capsule sized to be swallowed and pass through the intestinal tract. The capsule can include at least one guide tube, one or more tissue penetrating members positioned in the guide tube, a delivery member, an actuating mechanism and a release element. The release element degrades upon exposure to various conditions in the intestine so as to release and actuate the actuating mechanism. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.