Systems, methods, and/or apparatuses may be operative to perform a dialysis process that includes a displacer infusion process. The dialysis machine may include at least one processor and a memory coupled to the at least one processor, the memory comprising instructions that, when executed by the processor, may cause the at least one processor to access dialysis information for a dialysis process performed by a dialysis machine, the dialysis information indicating a target substance to be displaced from a binding compound by a displacer, and determine an infusion profile for infusing the displacer into a patient during a displacer infusion process of the dialysis process, the infusion profile determined based on the dialysis information and an infusion constraint. Other embodiments are described.

A device for injecting a product into a site, having: a body provided with a bearing wall for bearing on the site, a needle support mounted so as to be movable with respect to the bearing wall between: a pre-insertion position, at least one insertion position, and at least one retracted position, a catheter mounted so as to be movable with respect to the needle and intended to dispense product into the site, a drive unit intended to translate the needle support between the various positions of the needle support, a pump connected to a reservoir so as to transfer product from the reservoir to the catheter, a single electric motor intended to drive the drive unit and to supply the pump.

Various exemplary pumps with orientation independent liquid drug accessibility are provided. In general, a pump includes a reservoir configured to contain a liquid drug therein, a conduit configured to receive the drug therein from the reservoir, and a needle in fluid communication with the conduit and configured to deliver the drug therethrough to a patient wearing the pump. The conduit includes a mechanism configured to ensure that the conduit is in complete communication with the drug in the reservoir at least when the conduit is receiving the drug therein from the reservoir regardless of the patients orientation. In one exemplary embodiment, the mechanism includes a weight attached to the conduit. In another exemplary embodiment, the mechanism includes a fork at a free end of the conduit that is located in the reservoir.

Delivery systems and their methods of use for delivering one or more therapeutic compounds to a user are described. A delivery system may include an implantable pump and an external actuator. The implantable pump may include an actuatable portion that may be actuated to dispense a volume of fluid. The external actuator may include a pusher configured to deform skin to engage an actuatable portion of the pump. The external actuator may also include a positioning magnet configured to magnetically attract a portion of the implantable pump such that the external actuator and the pump may be aligned prior to applying force to the portion of the skin between the external actuator and the actuatable portion of the pump.

A device for delivering a medication to a patient in a drug infusion system is disclosed. The device is configured as a fully autonomous and integrated wearable apparatus for managing the medication delivery. The device comprises: a reservoir for storing the medication to be delivered to the patient; a continuous glucose monitoring device for monitoring glucose levels in the patient to set flow rates for medication delivery; a needle for delivering the medication from reservoir into the patient; and a pumping unit including one or more MEMS devices configured to function as (a) a pump for pumping the medication from the reservoir through a flow path for medication to the needle at set flow rates and/or (b) a valve for regulating flow of the medication in the flow path from the reservoir through the needle.

A device for delivering a medication to a patient in a drug infusion system is disclosed. The device is configured as a fully autonomous and integrated wearable apparatus for managing the medication delivery. The device comprises: a reservoir for storing the medication to be delivered to the patient; a continuous glucose monitoring device for monitoring glucose levels in the patient to set flow rates for medication delivery; a needle for delivering the medication from reservoir into the patient; and a pumping unit including one or more MEMS devices configured to function as (a) a pump for pumping the medication from the reservoir through a flow path for medication to the needle at set flow rates and/or (b) a valve for regulating flow of the medication in the flow path from the reservoir through the needle.

Urine collection systems and associated methods and devices are disclosed herein. A representative system can include a urine collection device, a flow control assembly configured to direct a urine flow from the patient to the urine collection device, and a urine measurement device including a first sensor and a second sensor. The first sensor is configured to generate first sensor data based on a weight of the container, and the second sensor is configured to generate second sensor data based on the urine flow from the patient to the container. The system can further include non-transitory computer readable media having instructions that, when executed by one or more processors, cause the system to perform operations comprising determining a first patient urine output based on the first sensor data; and determining a second patient urine output based on the second sensor data.

This application relates to a wearable multi-shot injection patch. In one aspect, the patch includes a base that has a bottom surface and a top surface and is configured so that the bottom surface is disposed against a patient's skin. The patch may also include a first container that is supported by the base and accommodates a first drug, and a second container that is supported by the base and accommodates a second drug. The patch may further include a first pyrotechnic charge disposed between the top surface and the first container inside the base, and a second pyrotechnic charge disposed between the top surface and the second container inside the base. The patch may further include one or more electronic components configured to detonate the first pyrotechnic charge and the second pyrotechnic charge.

A crawling mechanism for a drug delivery device has a central longitudinal axis and is arranged to crawl in an axial direction. The crawling mechanism includes a housing and one or more swing members pivotally coupled to the housing that are arranged to swing relative to the housing between an initial position and a terminal position suitable for urging crawling of the mechanism.

Integrated sensor and infusion devices are disclosed herein. The present technology includes, for example, an integrated sensor and infusion device for sensing physiological parameter(s) and delivering a medicament to a body of a user based at least in part on the sensed parameter(s). The device can comprise an insertion assembly comprising a carrier assembly comprising a cannula carrier, a trocar assembly removably coupled to the carrier assembly, and a drive assembly comprising a torsion spring coupled to the trocar assembly such that, when actuated, the torsion spring rotates to drive the trocar assembly and the carrier assembly axially downward to insert an infusion cannula and sensor electrode into a user's skin. The drive assembly can comprise a plurality of coupled drive wheels and/or a scissor assembly with multiple interacting links.