A method is provided for infusing a therapeutic. The method includes providing a microvalve device having an inner catheter longitudinally displaceable relative to an outer catheter, and a filter valve coupled to the inner catheter adjacent the distal ends of the inner and outer catheters such that longitudinal displacement of the inner catheter relative to the outer catheter permits the filter valve to be reconfigured from a first configuration to a second configuration. The filter valve is advanced to a target location in via a blood vessel in which the filter valve is configured under tension. Then in an embodiment, the tension is released and the filter valve is placed under compression. Then the therapeutic agent is infused through the inner catheter and out of the orifice of the inner catheter beyond the filter valve.

A method is provided for infusing a therapeutic. The method includes providing a microvalve device having an inner catheter longitudinally displaceable relative to an outer catheter, and a filter valve coupled to the inner catheter adjacent the distal ends of the inner and outer catheters such that longitudinal displacement of the inner catheter relative to the outer catheter permits the filter valve to be reconfigured from a first configuration to a second configuration. The filter valve is advanced to a target location in via a blood vessel in which the filter valve is configured under tension. Then in an embodiment, the tension is released and the filter valve is placed under compression. Then the therapeutic agent is infused through the inner catheter and out of the orifice of the inner catheter beyond the filter valve.

The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.

The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.

A filtration device includes: a housing that defines a liquid flow path; and a filtration sheet that separates the liquid flow path into a flow path upstream side and a flow path downstream side. The housing includes: a first housing member and a second housing member that sandwich the filtration sheet, and a joining member that joins the first housing member and the second housing member in a state in which the filtration sheet is sandwiched between the first housing member and the second housing member. A gap is located between the first housing member and the second housing at a position outward of an outer edge of the filtration sheet. The joining member seals the gap between the first housing member and the second housing member at the position outward of the outer edge of the filtration sheet.

A filtration device includes: a housing that defines a liquid flow path; and a filtration sheet that separates the liquid flow path into a flow path upstream side and a flow path downstream side. The housing includes: a first housing member and a second housing member that sandwich the filtration sheet, and a joining member that joins the first housing member and the second housing member in a state in which the filtration sheet is sandwiched between the first housing member and the second housing member. A gap is located between the first housing member and the second housing at a position outward of an outer edge of the filtration sheet. The joining member seals the gap between the first housing member and the second housing member at the position outward of the outer edge of the filtration sheet.

Embodiments of devices and methods to maintain preservative concentration in a medication delivered using a medical device are provided. A barrier layer can be used to prevent migration of preservatives. A vent can be used to allow release of preservatives prior to delivery to the patient. An absorbent element can be used to maintain preservative concentration at a desired level. A filter can be used to capture particulates from the medication prior to delivery to a patient.

A gas conditioning unit for a surgical gas delivery device is disclosed, which includes a filter housing having an insufflation gas flow path for delivering insufflation gas to a body cavity and for facilitating pressure measurements from the body cavity, a pressurized gas flow path for delivering pressurized gas from a pump in the surgical gas delivery device to an internal nozzle in the filter housing that accelerates the pressurized gas and thereby generates a continuous pressure barrier that inhibits egress of insufflation gas from the body cavity, a vacuum return flow path for returning depressurized gas spent by the internal nozzle back to the pump under vacuum, an air entrainment flow path for drawing air into the body cavity to maintain a given pressure therein, and a smoke evacuation flow path for conveying smoke from the body cavity.

A gas conditioning unit for a surgical gas delivery device is disclosed, which includes a filter housing having an insufflation gas flow path for delivering insufflation gas to a body cavity and for facilitating pressure measurements from the body cavity, a pressurized gas flow path for delivering pressurized gas from a pump in the surgical gas delivery device to an internal nozzle in the filter housing that accelerates the pressurized gas and thereby generates a continuous pressure barrier that inhibits egress of insufflation gas from the body cavity, a vacuum return flow path for returning depressurized gas spent by the internal nozzle back to the pump under vacuum, an air entrainment flow path for drawing air into the body cavity to maintain a given pressure therein, and a smoke evacuation flow path for conveying smoke from the body cavity.

A channel for a medicinal liquid is formed in a filter-integrated medicine transfer device according to an embodiment of the present disclosure. The filter-integrated medicine transfer device includes: a housing having an air passage that diverges from a medicinal liquid channel and is connected to outside; at least one hydrophobic air-passing filter disposed in the housing and disposed at a boundary between the air passage and the medicinal liquid channel; and at least one medicine transfer pipe disposed in the housing and having a capillary channel constituting a portion of the medicinal liquid channel.