Provided herein are, inter alia, devices, methods, and systems are provided for delivering pharmaceutical fluid formulations, such as with metered infusion capabilities delivered extravascularly to target locations within a patient while maintaining positional stability. An exemplary device can be configured to deliver non-continuous streams or boluses of fluid to a target site. In certain embodiments, the injection device can engage with an exemplary trocar that is configured to have one or more stabilization mechanisms on a shaft thereof such that the trocar provides a stable delivery mechanism to the injection device. The trocar is configured to receive an injection needle therein that is attached to the injection device, and the injection device can deliver fluid therethrough to a target tissue site.

A device for delivery of a radiopharmaceutical and, in some embodiments, delivery of a pharmaceutical agent are described herein. Various other components for delivery systems including tubing management systems, primer caps, diffusion chambers, radiation shields and syringe shields, and other devices and methods are also described.

In the present disclosure, embodiments include flaring tip microcatheters, methods of deploying flaring tip microcatheters, and embolization treatment methods. The flaring tip microcatheter may include a hollow shaft having a shaft lumen defined therein, a core disposed within the shaft lumen, and a tip including at least two petals affixed to a distal end of the core, the at least two petals including at least two wires wherein the core is hollow and defines a core lumen. The at least two wires may be configured to pull the at least two petals to form a flared configuration of the tip. The flared configuration of the tip may allow for laminar flow of a therapeutic agent distally from the tip.

A shielding assembly for an infusion system includes a plurality of compartments and a door for each compartment, and provides a radioactive radiation barrier for the compartments. One of the compartments contains a radioisotope generator of the infusion system and another of the compartments may contain a waste bottle of the infusion system. An opening into each of the generator and waste bottle compartments may be oriented upward, and the opening into the latter may be at a higher elevation than the opening into the former, for example, to facilitate independent removal and replacement of each. A door of at least one of the compartments, other than the generator compartment, when closed, may prevent the door of the generator compartment from being opened. A cabinet structure for the infusion system may enclose the shielding assembly and secure the generator.

The invention is a theranostic delivery system or radiopharmaceutical drugs delivery system with movable workstation having handles. The workstation of theranostic delivery system or radiopharmaceutical drugs delivery system also has an on-board shielded disposal system for waste collection, which is operated by foot actuated system for locked and unlocked modes during the device journey. The theranostic delivery system or radiopharmaceutical drugs delivery system comprises a status light system that illuminates the working area to enable distance monitoring. Further, the delivery system includes a disposable secondary containment system that protects the core workstation from contamination, a configurable dose transporter and a disposable sealed fluid cartridge to withdraw custom volume from the vial or syringe. The delivery system includes a theranostic informatics management system, which contains a computer screen as a graphical user interface with a retractable rotating arm to receive the various patient infusion parameters.

In the present disclosure, embodiments of flaring tip microcatheters, methods of deploying flaring tip microcatheters, and embolization treatment methods are disclosed. The flaring tip microcatheter may include a hollow shaft having a shaft lumen defined therein, a core disposed within the shaft lumen, and a tip comprising at least two petals affixed to a distal end of the core, the at least two petals comprising at least two wires wherein the core is hollow and defines a core lumen. The at least two wires may be configured to pull the at least two petals to form a flared configuration of the tip. The flared configuration of the tip may allow for laminar flow of a therapeutic agent distally from the tip.

The invention is a theranostic delivery system or radiopharmaceutical drugs delivery system with movable workstation having handles. The workstation of theranostic delivery system or radiopharmaceutical drugs delivery system also has an on-board shielded disposal system for waste collection, which is operated by foot actuated system for locked and unlocked modes during the device journey. The theranostic delivery system or radiopharmaceutical drugs delivery system comprises a status light system that illuminates the working area to enable distance monitoring. Further, the delivery system includes a disposable secondary containment system that protects the core workstation from contamination, a configurable dose transporter and a disposable sealed fluid cartridge to withdraw custom volume from the vial or syringe. The delivery system includes a theranostic informatics management system, which contains a computer screen as a graphical user interface with a retractable rotating arm to receive the various patient infusion parameters.

Methods and systems for determination of flow parameters of administered fluid from a radioembolization delivery device may include translationally moving a device delivery arm of the radioembolization delivery device in a translational direction, wherein the device delivery arm is coupled to a syringe holder such that move in the translational direction one of proximally or distally advances the syringe holder; sensing, via one or more pattern sensors, a corresponding movement of a pattern associated with the translational device delivery arm movement as a sensed pattern movement; generating, via the one or more pattern sensors, one or more output signals based on the sensed pattern movement; and generating, via a processor, a flow rate of the administered fluid, a flow amount of the administered fluid, and/or the translational direction of movement of the device delivery arm with respect to the syringe holder based on the one or more output signals.

A vial holder is provided to protect a user's hand from needle sticks. The holder includes a handle and a shield attached to a distal end of the handle. An opening is formed in the distal end of the handle to receive a vial. The vial is placed through the opening and into a passageway of the handle with the upper end of the vial exposed. A user grasps the handle which holds the vial in a stabilized manner. A needle may then safely approach the vial in which inadvertent slippage or movement of the needle results in contact with the needle against the shield and not contact with the user's hand.

An integrated radiopharmaceutical patient treatment system is disclosed including a patient support platform with an associated patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with a patient, and an integrated system controller operably associated with the patient stimulus apparatus, imager, radiopharmaceutical fluid delivery system, and patient monitor to control and coordinate their operations. Within the patient treatment system the radiopharmaceutical fluid delivery system may be included comprising a radionuclide supply module, a radiopharmaceutical processing module, a quality control module, a patient injection module, and a controller. A hazardous fluid handling system including a docking station and a hazardous fluid transport device adapted to detachably dock with the docking station is further disclosed.