Methods of bioprinting a bio-ink construct on an internal tissue defect or a chondral defect during a minimally invasive surgery on an individual in need thereof are provided, comprising: visualizing the defect; positioning a bioprinter comprising a printhead within proximity of or in contact with the defect; and ejecting a bio-ink from the printhead onto the defect to form a bio-ink layer, thereby generating a bio-ink construct. Further provided are systems for bioprinting a bio-ink construct on an internal tissue defect during a minimally invasive surgery on an individual in need thereof, comprising a control system, an endoscope, and a bioprinter comprising a printhead.

A sensor assembly for an injection device may include a housing and/or a mechanical interface. The housing may include a sensor and/or a wireless communication device. The sensor may be configured to detect a movement of a component of the injection device associated with an injection operation of the injection device. The wireless communication device may be configured to communicate, to a computing device, information associated with the movement of the component of the injection device. The mechanical interface may be configured to attach the housing to an exterior surface of the injection device. A system may include the sensor assembly and the injection device.

A sealable joint including a first component, a second component, and a third component. The first component includes a stem having a bore therethrough for the passage of a fluid. The second component is disposed on the first component, and the third component includes a sealing surface and one or more radially inwardly projecting members. One of the second component and the first component, or a combination of the second component and the first component includes a first flange and a second flange that defines an annular recess therebetween. In a sealing configuration, the second component is received by the third component to form a sealed joint in which at least part of the first flange deforms against the sealing surface, the one or more radially inwardly projecting members are disposed in the annular recess between the first flange and the second flange.

A sealable joint including a first component, a second component, and a third component. The first component includes a stem having a bore therethrough for the passage of a fluid. The second component is disposed on the first component, and the third component includes a sealing surface and one or more radially inwardly projecting members. One of the second component and the first component, or a combination of the second component and the first component includes a first flange and a second flange that defines an annular recess therebetween. In a sealing configuration, the second component is received by the third component to form a sealed joint in which at least part of the first flange deforms against the sealing surface, the one or more radially inwardly projecting members are disposed in the annular recess between the first flange and the second flange.

A disposable, single-dose delivery device for self-administration by a patient of a predefined amount or dose of drug from a reservoir through an outlet of the reservoir includes a device operation lock to prevent a delivery operation of the delivery device as shipped to the patient, an embedded electronic control unit with a wireless receiver for receiving an unlock command or message, and an electromechanical actuator for mechanically unlocking the device operation lock and enabling delivery device operation by the patient. The control unit is configured to activate the actuator instantaneously and unconditionally upon receipt of the unlock command. The unlocking mechanism of the delivery device is adapted to be activated from remote in response to a confirmative message indicative of additional double check by a Health Care Professional HCP or expert system.

A disposable, single-dose delivery device for self-administration by a patient of a predefined amount or dose of drug from a reservoir through an outlet of the reservoir includes a device operation lock to prevent a delivery operation of the delivery device as shipped to the patient, an embedded electronic control unit with a wireless receiver for receiving an unlock command or message, and an electromechanical actuator for mechanically unlocking the device operation lock and enabling delivery device operation by the patient. The control unit is configured to activate the actuator instantaneously and unconditionally upon receipt of the unlock command. The unlocking mechanism of the delivery device is adapted to be activated from remote in response to a confirmative message indicative of additional double check by a Health Care Professional HCP or expert system.

An injector for injecting a medicament in a patient. The injector includes a container comprising a fluid chamber containing a first volume of a medicament, and an injection conduit associated with the fluid chamber for defining a fluid pathway therefrom to inject the medicament from the fluid chamber through the injection conduit to an injection location. The injector also includes a firing mechanism associated with the fluid chamber for expelling the medicament from the fluid chamber through the injection conduit, arid a volume-control mechanism operable to control a fraction of the first volume of medicament that is injected when the firing mechanism is actuated to inject the medicament.

Systems, devices and methods are provided for the integration of an analyte data reader and a medication delivery device. The integrated device can include a medication delivery portion, wireless communications circuitry configured to receive data indicative of an analyte level, and electronics. The integrated device can also include one or more near-field communication (NFC) antennas. Example embodiments of adverse condition protection features of the integrated device are also provided.

Described herein is a generalized injection device for delivering formulations of various mechanical properties to precise locations. Of particular interest is the manifestation intended for the application of a thermally responsive hydrogel to the tear duct for the purpose of occlusion, as a treatment for symptoms associated with dry eye syndrome. Further, a modular solution to the need for an injection device across a variety of applications, mechanism, and physical considerations is provided. This disclosure provides examples of methods for precise injection of low volumes, moisture retention in pre-filled injection devices, and actuation for automatic or manual injection, to name a few.

Medication delivery devices are provided having a housing comprising a reservoir sized sufficiently to hold medication, a dose button being rotatable relative to the housing to select a dose size of the medication for an injection, a printed circuit board, a switch mounted to the printed circuit board, and a controller in communication with the switch. The controller is configured to generate a first count of a set of signals using a first counting technique, generate a second count of the set of signals using a second counting technique, and determine, based on the first and second count, reliability data of the first and/or second count. The controller can connect, using a wireless communication module, to a remote computing device to wirelessly communicate with the remote computing device over an unencrypted wireless communication channel, and transmit, using the wireless communication module, encrypted data to the remote computing device.