A cassette including: a cartridge holder including a first end, a second end having a holder opening, and a holder columnar space located between the first end and the second end and capable of accommodating a drug cartridge, drug cartridge including: a cylinder including a first end at which an injection needle is insertable/extractable, a second end at which a cylinder opening is located, and a cylinder columnar space located between the first end and the second end; a drug placed in the cylinder columnar space; and a gasket being placed in the cylinder columnar space; a cassette cap capable of opening and closing the holder opening, the cassette cap including a first end having a cap opening that is opposed to the holder opening, a second end having a piston insertion opening, and a cap columnar space located between the first end and the second end.

A method for manufacturing or selecting a medical device, such as a reservoir-based delivery device, for use in contact with a fluid composition, such as a drug formulation, includes considering one or more of: (i) the differential Hansen Solubility Parameter (HSP) value for and ingredient of the fluid composition and a component of a medical device; (ii) the concentration of the ingredient in the fluid composition relative to the maximum solubility of the ingredient in the fluid composition at the pH of the concentration; (iii) the potential for chemical reaction between the ingredient of the fluid composition and the component of the medical device; and (iv) baseline reactivity of the fluid composition with the component of the medical device.

An automatic injection device, including a housing arranged along a longitudinal axis and having a forward end and a rearward end, the housing is configured to receive a syringe including at least one syringe piston and a needle coupled to a forward end thereof; a plunger rod adapted to be retained with respect to the housing in an initial operative orientation; at least one resilient element arranged to forwardly bias the plunger rod relative to the syringe; a needle shield adapted for selectable axial displacement with respect to the housing along the longitudinal axis, whereas rearward displacement of the needle shield exposes the needle and forward displacement of the needle shield covers the needle; and a trigger element configured to be axially rearwardly displaced upon rearward displacement of the needle shield relative to the housing and thereby allow forward displacement of the plunger rod relative to the syringe under the urge of the at least one resilient element.

An automatic injection device, including a housing arranged along a longitudinal axis and having a forward end and a rearward end, the housing is configured to receive a syringe including at least one syringe piston and a needle coupled to a forward end thereof; a plunger rod adapted to be retained with respect to the housing in an initial operative orientation; at least one resilient element arranged to forwardly bias the plunger rod relative to the syringe; a needle shield adapted for selectable axial displacement with respect to the housing along the longitudinal axis, whereas rearward displacement of the needle shield exposes the needle and forward displacement of the needle shield covers the needle; and a trigger element configured to be axially rearwardly displaced upon rearward displacement of the needle shield relative to the housing and thereby allow forward displacement of the plunger rod relative to the syringe under the urge of the at least one resilient element.

An ingestible device is disclosed suitable for swallowing into a lumen of a gastrointestinal tract of a patient, the lumen having a lumen wall. The ingestible device (100, 200) comprises: a capsule (110, 120), a delivery member (130) being shaped to penetrate tissue of a lumen wall and having a tissue penetrating end and a trailing end, the delivery member (130) comprising a therapeutic payload, a ram (150) attached relative to the delivery member (130) at the trailing end; and an actuator (140) coupled to the ram (150) and having a first configuration and a second configuration, the delivery member (130) being retained by the ram (150) within the capsule (110, 120) when the actuator (140) is in the first configuration, wherein the delivery member (130) is configured to be advanced from the capsule (110, 120) and into the lumen wall by movement of the actuator (140) from the first configuration to the second configuration such that the delivery member (130) moves along a predefined trajectory. The ram (150) is configured for being tilted relative to the predefined trajectory upon the actuator (140) moving into the second configuration to detach at least a portion of the delivery member (130) from the ram (150) such that the detached portion of the delivery member (130) remains within the lumen wall to release therapeutic payload.

Drug delivery system, injection device, transfer apparatus, vial holder and method of administering and transferring are disclosed which provide for passive warming of chilled injectable transferred through the transfer apparatus and into the injection device. The injection device may include a skin-facing surface including a skin boundary displacement extension or structure around a needle injection site to create a high pressure zone in the tissue. Radio frequency tracking and monitoring features for tracking patient compliance also may be provided.

Drug delivery system, injection device, transfer apparatus, vial holder and method of administering and transferring are disclosed which provide for passive warming of chilled injectable transferred through the transfer apparatus and into the injection device. The injection device may include a skin-facing surface including a skin boundary displacement extension or structure around a needle injection site to create a high pressure zone in the tissue. Radio frequency tracking and monitoring features for tracking patient compliance also may be provided.

The present disclosure relates to a drug delivery device, comprising a shell adapted to contain one of a plurality of medicament containers prefilled with different deliverable volumes of a medicament. The shell is transparent at least in an area adapted to contain the medicament container, and a label adapted to be arranged on the shell. The label comprises a foil having a first surface and a second surface, which is adapted to be connected to the shell. At least one cutout or transparent area is arranged in the foil adapted to be placed on the shell such that a medicament container arrangeable or arranged within the shell is visible through the cutout or transparent area. The cutout or transparent area exhibits a size adapted to allow inspection of the deliverable volume of medicament within the medicament container when the label is applied to the shell.

The present disclosure relates to a drug delivery device, comprising a shell adapted to contain one of a plurality of medicament containers prefilled with different deliverable volumes of a medicament. The shell is transparent at least in an area adapted to contain the medicament container, and a label adapted to be arranged on the shell. The label comprises a foil having a first surface and a second surface, which is adapted to be connected to the shell. At least one cutout or transparent area is arranged in the foil adapted to be placed on the shell such that a medicament container arrangeable or arranged within the shell is visible through the cutout or transparent area. The cutout or transparent area exhibits a size adapted to allow inspection of the deliverable volume of medicament within the medicament container when the label is applied to the shell.

A method for preparing a pre-filled multi-chamber injection system includes providing an injection system body, the injection system body defining an open proximal end, a body interior, and an open distal end. The method also includes introducing a first substance into a distal end of the body interior. The method further includes disposing a distal stopper member in the body interior, the distal stopper member and the injection system body defining proximal and distal chambers in the body interior. Moreover, the method includes introducing a second substance into the body interior. In addition, the method includes disposing a proximal stopper member in the body interior. The method also includes inserting an elongate member at least partially into the body interior, the elongate member having a plurality of flow channels for fluidly coupling the proximal and distal chambers. The method further includes coupling a plunger member to the proximal stopper member.