The invention discloses a sterile syringe (100) comprising a barrel (1) having internal surfaces (2), a plunger (3) movable within the barrel, a non-sliding seal (7) between the barrel and the plunger defining a sealed volume (8) and at least one filter (9) allowing only filtered gases to enter the sealed volume such that the syringe maintains its sterility even after several uses. The filters could be positioned on different locations on the syringe like on the non-sliding seal, the barrel, the barrel flange or the plunger handle.

A drug delivery device includes a container for storing a drug having a longitudinal axis. A plunger rod aligned with the longitudinal axis of the container has a first end and a second end, where the second end is disposed within the container. A stopper is disposed in and movable relative to the container for expelling the drug, and a drive mechanism is operatively coupled to the first end of the plunger rod. The drive mechanism is configured to deliver a drive force to move the plunger rod along the longitudinal axis and through the container. A chamber disposed between a plunger rod and the stopper is adapted to oppose the drive force of the drive mechanism.

A fat suction and graft syringe includes a negative pressure adjustment mechanism. The negative pressure state in a barrel can be maintained during a procedure only by pulling and releasing a plunger, and only by slightly rotating the plunger. The plunger can be pushed inside the barrel without being constrained by a multi-level holding plate and a single-surface rotation clip, whereby the syringe has enhanced convenience in the use and production thereof so that many practitioners accustomed to using a normal syringe can easily use the syringe without separately learning how to manipulate the syringe.

A method for preparing a pre-filled multi-chamber injection system includes providing an injection system body, the injection system body defining an open proximal end, a body interior, and an open distal end. The method also includes introducing a first substance into a distal end of the body interior. The method further includes disposing a distal stopper member in the body interior, the distal stopper member and the injection system body defining proximal and distal chambers in the body interior. Moreover, the method includes introducing a second substance into the body interior. In addition, the method includes disposing a proximal stopper member in the body interior. The method also includes inserting an elongate member at least partially into the body interior, the elongate member having a plurality of flow channels for fluidly coupling the proximal and distal chambers. The method further includes coupling a plunger member to the proximal stopper member.

A syringe with an integrated guidewire tract. The tract provides a physical channel by which a guidewire is guided through the syringe structure. The syringe is configured to allow for a one-handed aspiration operation or injection operation, while freeing the other hand to move the guidewire through the guidewire tract of the syringe system.

A double barreled injector assembly for performing multiple sequential vaccinations includes a pair of barrels, each of which is engaged by a first terminus thereof to a bar and extends from a lower face thereof. A respective agent can be positioned in each barrel. Each barrel has an orifice positioned in a second terminus thereof. A pair of actuators is engaged to an upper face of the bar. Each actuator is operationally engaged to a respective barrel and can be actuated by action of a hand of a user to dispense an associated agent through the orifice of the respective barrel into an animal. The injector assembly allows the user to perform multiple sequential vaccinations with two different vaccines and will be useful in vaccination of herds or flocks of livestock, such as poultry, cattle, and the like.

A closure assembly for a medical device, preferably in the form of a tamper evident closure, having an outer sleeve including an open end and a closed end. A tip cap includes a flow restrictor disposed within the sleeve in accessible relation by the medical device through the open end. An indicator member is removably connected to the tip cap within the sleeve and a retainer member is connected to an interior of the sleeve in an interruptive, disconnecting relation to the indicator member by a snap-fit connection. The indicator member is captured within said hollow interior upon removal of said tip cap from the sleeve through the open end. An end cap may be attached to the sleeve, to define a closed end thereof, by a snap-fit connection similar to, but distinguishable from, the snap-fit connection between the retainer member and the interior of the sleeve.

A closure assembly for a medical device, preferably in the form of a tamper evident closure, having an outer sleeve including an open end and a closed end. A tip cap includes a flow restrictor disposed within the sleeve in accessible relation by the medical device through the open end. An indicator member is removably connected to the tip cap within the sleeve and a retainer member is connected to an interior of the sleeve in an interruptive, disconnecting relation to the indicator member by a snap-fit connection. The indicator member is captured within said hollow interior upon removal of said tip cap from the sleeve through the open end. An end cap may be attached to the sleeve, to define a closed end thereof, by a snap-fit connection similar to, but distinguishable from, the snap-fit connection between the retainer member and the interior of the sleeve.

A device and method for measuring a volume of liquid expelled from a syringe is provided. The device generally includes a syringe barrel, a plunger actuated with a plunger rod, and a sensor. The sensor may include two ports with one port being in fluid communication with a source of fluid external to the syringe barrel, while the second port is in fluid communication either with a proximal end portion of the syringe barrel or a hollow plunger rod having a first end closed by the plunger. The method may include expelling liquid from the syringe; detecting and recording differential pressure with the sensor over time; and calculating the volume of liquid expelled from the syringe from the recorded differential pressure over time.

Syringes, assemblies for use in a filling process, and related methods of manufacture are disclosed. A syringe may include a reservoir filled or configured to be filled with a preselected volume of a drug, including, for example, a preselected volume of 3 mL or approximately 3 mL of the drug. The syringe may further include a wall comprising a cylindrical portion. The cylindrical portion of the wall may include: (a) an inner diameter equal to or approximately equal to a standard inner diameter of a 5 mL syringe or a standard outer diameter of any other syringe volume not equal to the preselected volume or 3 mL; and/or (b) an outer diameter equal to or approximately equal to a standard outer diameter of a 5 mL syringe or a standard outer diameter of any other syringe volume not equal to the preselected volume or 3 mL.