A preferred method to obtain a painless or near painless needle 8 penetration is disclosed to be in the following manner: Applying electric current using a TENS device in conjunction with physically stimulating the injection site at a frequency that is dependent on the frequency of the electric current applied to the injection site, followed by a needle 8 penetration into the skin 2.

A handheld cryoanesthesia or analgesia device for cooling a target area on cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone having an elongated body and a thermoelectric cooling system disposed within the elongated body. The thermoelectric cooling system is configured to physically contact and thermally couple the target area of the cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone to induce cryoanesthesia or analgesia. The thermoelectric cooling system includes a thermally-conductive cold tip, a thermally-conductive cooling power concentrator thermally coupled to the cold tip, at least one Peltier unit module thermally coupled to the cooling power concentrator, a heatsink thermally coupled to at least one Peltier unit module, a power source, at least one thermal sensor, and a controller operably outputting a control signal to the Peltier unit module to maintain a predetermined temperature.

The present disclosure provides a device and a method for cooling living tissues for a medical purpose and other purposes. The cooling device comprises: a container configured to accommodate a cooling medium, the container including a plurality of divided members each having a contact surface which is thermally coupled with the cooling medium; a cooling generator configured to provide cooling energy to the container, and disposed on another surface of the divided member other than the contact surface; and a lubricating member provided to the contact surface of the divided member, wherein the container is configured to be thermally coupled with the cooling medium via the lubricating member.

The present disclosure provides a device and a method for cooling living tissues for a medical purpose and other purposes. The cooling device comprises: a container configured to accommodate a cooling medium and thermally coupled with the cooling medium by directly contacting the cooling medium; a cooling generator configured to be thermally coupled with the container by a direct contact and thereby to provide cooling energy to the cooling medium; and a heat sink dissipating heat from the cooling generator, the heat sing being configured to be spaced apart from the cooling generator and to be thermally coupled with the cooling generator without a direct contact with the cooling generator.

The present disclosure provides a device and a method for cooling living tissues for a medical purpose and other purposes. The cooling device includes a cooling medium contacting the living tissues to be cooled. The cooling medium comprises: a first fluid medicine reservoir configured to be installed outside a main body that couples with a medical cooling device and to move into the main body, wherein the first fluid medicine reservoir stores a first fluid medicine to be injected through a hole at a tip of the main body.

A handheld cryoanesthesia or analgesia device for cooling a target area on cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone having an elongated body and a thermoelectric cooling system disposed within the elongated body. The thermoelectric cooling system is configured to physically contact and thermally couple the target area of the cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone to induce cryoanesthesia or analgesia. The thermoelectric cooling system includes a thermally-conductive cold tip, a thermally-conductive cooling power concentrator thermally coupled to the cold tip, at least one Peltier unit module thermally coupled to the cooling power concentrator, a heatsink thermally coupled to at least one Peltier unit module, a power source, at least one thermal sensor, and a controller operably outputting a control signal to the Peltier unit module to maintain a predetermined temperature.

A topical cooling device for cooling and desensitizing the surface of the skin of a patient is provided that includes a thermally insulating container having at least one side wall, an open end and a closed end, and internal cavity. A thermally transmitting member is included for closing the open end of said container. A refrigerant medium is provided within the cavity of the container and in contact said thermally transmitting member for cooling the surface of the skin of a patient in contact with the thermally transmitting member. The refrigerant medium can be hypertonic aqueous sodium chloride solution. The thermally transmitting member can be flexible bladder that is received within the container where the refrigerant medium is thermally insulated by the container. A lid can be attached to the open end of the container to close the device until ready for use.

A pain-reducing injection apparatus to enhance the safety, efficacy, and efficiency of injection procedures which utilize topical pain-reducing measures. Apparatuses and methods of use provide pain reduction through thermal cooling of an injection region or vibrating the region or both, and optionally include safety shielding and lockout features.

The disclosure relates to an automatic medical injection device including a flexible reservoir prefilled with a medical solution. The reservoir includes a needle for injecting the medical solution into a patient's body, and a body removably enclosing the reservoir. The body includes a lower surface adapted to be applied against the patient's skin during an injection of the medical solution, said lower surface including a throughhole adapted for the passage of the needle, and an upper surface opposite to the lower surface, a compression device configured for compressing the reservoir to expel the medical solution through the needle, and an activation button configured to trigger the compression device upon activation by a user.

Methods of modifying a medical device and manufacturing a medical device are disclosed. One embodiment of a method of modifying a medical device includes treating a portion of the medical device with cold plasma and functionalizing the plasma-treated portion with a polymer. One embodiment of a method of manufacturing a medical device includes providing a subcutaneous part configured to be positioned subcutaneously in a user and performing a surface treatment on a portion of the subcutaneous part.