A single-use medical syringe having a plunger with a sealing element arranged on a distal end of the plunger head to contact the medicament in the syringe body and one or more hollow piercing elements disposed in the interior of the syringe body between a distal surface of the interior and the sealing element of the plunger head, wherein the one or more hollow piercing elements are arranged axially with respect to the syringe and positioned to be driven though the sealing element when the sealing element is driven against the distal surface at the end of the injection operation, wherein, at the end of the injection operation, the one or more hollow piercing elements create a fluid passageway across the plunger head when the one or more hollow piercing elements pierce through the sealing element of the plunger head.

A drug delivery device includes a housing, a mechanical assembly which is at least partially accommodated in the housing and a retaining member for retaining the mechanical assembly in the housing wherein the retaining member is engaged with the housing such that the device is configured to be damaged when the mechanical assembly or parts thereof are forcefully separated from the housing.

A safety syringe (100; 700; 1200) comprising: a barrel (104; 704; 1204) having an opening at an end thereof; a syringe plunger (108; 708; 1208) configured to move within the barrel such that an inward stroke of the syringe plunger causes a substance within the barrel to be expelled from the opening; and a sheath (112; 712; 1212) configured to cover at least partially the opening in the barrel after use of the syringe, wherein the sheath is coupled to the syringe plunger and is configured to decouple from the syringe plunger at a point on the inward stroke such that the sheath is moveable independently of the syringe plunger and further movement of the sheath after decoupling at least partially covers the opening in the barrel.

A pre-filled pharmaceutical package comprising a liquid formulation of a VEGF-antagonist, for example Ranibizumab, inside the package. A nonlimiting example of the package can be a syringe, cartridge, or vial, made in part or in whole of a thermoplastic polymer, coated on the interior with a tie coating or layer, a barrier coating or layer, a pH protective coating or layer, and optionally a lubricity coating or layer. Optionally, the package further comprises a bag, a blister, a pouch or any other vessel. Stability performance of the VEGF-antagonist packaged in the coated COP vessel comparable to or better than glass was obtained. The said pre-filled pharmaceutical package comprising a liquid formulation of a VEGF-antagonist is suitable for sterilization (such as for surface and/or terminal sterilization) with sterilization gas residuals being minimal and/or lower than required by ISO 10993-7.

A safety syringe (100; 700; 1200) comprising: a barrel (104; 704; 1204) having an opening at an end thereof; a syringe plunger (108; 708; 1208) configured to move within the barrel such that an inward stroke of the syringe plunger causes a substance within the barrel to be expelled from the opening; and a sheath (112; 712; 1212) configured to cover at least partially the opening in the barrel after use of the syringe, wherein the sheath is coupled to the syringe plunger and is configured to decouple from the syringe plunger at a point on the inward stroke such that the sheath is moveable independently of the syringe plunger and further movement of the sheath after decoupling at least partially covers the opening in the barrel.

An improved system and method for a syringe capable of reducing re-usage and limiting wasted contents. The syringe has a plunger with a plunger plug that extends beyond the barrel of the syringe when the contents are fully dispensed and prevents the plunger from being drawn backward. The plunger may also consist of a two-piece design that separates upon exceeding a predetermined force when attempting to draw the plunger backward after use.

An injection device including a barrel having a medicament reservoir therein capable of fluid communication with a needle assembly at a distal end thereof and sealed at a proximal end thereof with a stopper. The injection device further includes a plunger rod having a distal rod end which is couplable with said stopper, wherein, when the plunger rod is coupled to the stopper, forward axial movement of the plunger rod causes forward axial movement of the stopper coupled thereto into the medicament reservoir in order to expel medicament through the needle assembly. Further, the plunger rod can be decoupled from the stopper by applying a rearward axial force on the plunger rod, said rearward axial decoupling force being less than a rearward axial force required to move the stopper rearwardly with respect to the barrel.

Embodiments of a retractable syringe assembly are provided that include a dual syringe barrel configuration. One or more embodiments include reuse prevention features and features that prevent premature activation of the retraction mechanism. Methods for aspirating and expelling liquid from medical devices are also provided.

A syringe includes a barrel having first and second ends, with the barrel defining an interior space and a stopper positioned therein, the stopper moveable within the interior space relative to the barrel, a plunger connected to the stopper, and a collar having threads configured to engage threads of a medical connector. The collar is at least partially received by the barrel, with one of the barrel and the collar defining a slot and the other of the barrel and the collar having a pin received within the slot. The collar has a connection position where the collar is fixed relative to the barrel when the syringe is being connected to the medical connector, a disconnection position where the collar is fixed relative to the barrel when the syringe is being disconnected from the medical connector, and a reuse prevention position wherein the collar is rotatable relative to the barrel.

Disclosed is a single use self-disabling syringe capable of preventing the syringe from being reused after the syringe is used once on a patient, thereby preventing syringe reuse. The single use self-disabling syringe includes: a barrel having a needle attached to a tip end thereof and a fluid containing space defined therein, the fluid containing space being open at a rear end of the barrel; a plunger contained in the barrel and configured to draw in and expel a fluid; and a syringe reuse prevention means provided in the barrel along an inner surface thereof in an axial direction and configured to tear a part of the plunger so as to prevent the syringe from being reused.