An aerosol medicament delivery adapter (20) comprises a first conduit (22), second conduit (24) and a diverter element (26). The first conduit (22) encloses a flow path chamber (28) and extends between an upstream first end (34) and a downstream second end (36). The second conduit (24) comprises an aerosol medicament delivery conduit that includes an upstream first end (48) adapted to be fluidly coupled to a particle generator (14), and a downstream second end (50) fluidly coupled to the first conduit at a Y-junction (54) proximate the upstream first end of the first conduit. The diverter element (26) comprises a flow diverter chamber (60) disposed within the first conduit (22) or the second conduit (24). The cylindrical flow diverter chamber (60) includes a transitional flow cross-section (62) and a principal axis (64), extending between a first end (66) and a second end (68) thereof. The diverter element creates flow eddies for enhancing an entrainment of aerosol particles, delivered via the second conduit, within a pressurized gas flow along the flow path within the first conduit.

The present invention relates to a single-dose dry powder inhaler comprising a base assembly comprising a chamber (14) configured for receiving a medication; and a mouthpiece assembly comprising air intake passages (25) for supplying air to the inhaler, a rotation chamber (26) for generating an aerosol of a medication, wherein the rotation chamber (26) is in air communication with the air intake passages (25), a tube (21C) comprising an internal passage in air communication with the rotation chamber (26) for discharging an aerosol of a medication and for administering said aerosol to a patient; wherein the base assembly and the mouthpiece assembly are configured such that the inhaler is capable of assuming an open configuration, in which access to the chamber (14) of the base assembly is provided for inserting therein a medication, and a closed configuration, in which the chamber (14) of the base assembly is in air communication with the rotation chamber (16) of the mouthpiece assembly for transferring a medication from the chamber (14) to the rotation chamber (16) for forming out of it an aerosol of the medication, and wherein at least one of the air intake passages (25) and the tube (21C) of the mouthpiece assembly is selectable, and in that the air intake passages (25) have a ratio of one of the transverse dimensions (H, W) to the other of the transverse dimensions (H, W) in the range from 1:1 to 1:0.10 and the tube (21C) comprises a constriction (27) arranged in the internal passage of the tube such that the coverage of the passage is in the range from 0% to 95%. The present invention relates also to a method for adjusting a single-dose dry powder inhaler for administering a specific medication.

Nebulizer systems, apparatus, and methods are disclosed. The apparatus includes a body, a breathing gas inlet and outlet, and a barrier. The body is sized to be positioned within an adaptor of the nebulizer system. The breathing gas inlet and the breathing gas outlet are at opposite ends of the body. The barrier is coupled to the body. A plurality of holes are formed in the barrier. The plurality of holes open in a direction orthogonal to the breathing gas inlet. The system employs the apparatus in conjunction with a nebulizer and an adaptor. The method includes generating an aerosolized medicament, providing the aerosolized medicament to the adaptor, passing the aerosolized medicament through the barrier of the apparatus, providing a breathing gas to the apparatus, and flowing the aerosolized medicament and the breathing gas through the breathing gas outlet of the apparatus.

A system and a method for generating a respirable dry powder aerosol (15) from a liquid solution or liquid suspension at a respirable dry powder aerosol volume flow (91). A liquid aerosol generating nozzle (3) generates from the liquid solution or liquid suspension a liquid aerosol (13) that is diluted by dilution gas (4) and dried in a cylindrical evaporation chamber (6) to generate a dry powder aerosol (14) that is subsequently concentrated. The system and method may include heliox as a gas, specifically dilution gas (4), for enhancing both the drying process in the cylindrical evaporation chamber (6) and for enhancing the concentration efficiency, but also as a nozzle gas (2) for enhancing generating the liquid aerosol (13) from the liquid solution or liquid suspension.

A fluid dispenser device with a main body (10); a reservoir (21) containing a dose of powder; a reservoir opening mechanism (80); a dispenser orifice (5); a movable support mechanism (50) to displace a reservoir (21) against the opening mechanism on actuation and displaceable between a non-dispensing position and a dispensing position, urged towards the dispensing position, and held in the non-dispensing position by a blocking mechanism (100). An inhalation trigger system (60) is provided that has a deformable air chamber (61) and a trigger element (600) that co-operates firstly with the air chamber (61) and secondly with the blocking mechanism. The fluid dispenser device further includes an electronic dose counter or indicator device (300) including a sensor (306) to detect displacement or deformation of a portion of the fluid dispenser device, generated while the user is inhaling or after the user has inhaled.

A system can include a nebulizer having a tip and a spray chamber configured to be in fluid communication with the nebulizer. The tip of the nebulizer and/or an interior of the spray chamber can have a treated surface. The nebulizer and/or the spray chamber can be treated using a physical abrasion technique, chemically etched, and so forth. In some embodiments, treated surfaces of the nebulizer and the spray chamber can be proximate to one another. The spray chamber can include a drain ridge, which can project into an interior of the spray chamber, be depressed away from an interior of the spray chamber, and/or include a treated surface. The spray chamber can also include an output port having a treated surface. In some embodiments, the output port can include an additional port so that rinse liquid can flow through the spray chamber (e.g., continuously and/or intermittently).

A supplemental oxygen delivery system is described in which Aerosol is delivered into a housing 10, 20, which sits in the circuit from the supplemental oxygen supply and optional humidifier. The supplemental oxygen passes through this chamber 10, 20 in which the aerosol is located, and collects the aerosol transporting it to a patient via a nasal cannula 3 or a face mask 4. An aerosol generator 9 is mounted to the housing 10, 20 and delivers aerosol into an oxygen stream 13 flowing between an inlet 14 and an outlet 15 of the housing 10. The housing 10 also has a removable plug 16 in the base 17 thereof for draining any liquid that accumulates in the housing 10. There is no disruption of oxygen delivery to patients using nasal cannulas who currently have to use a separate face-mask when receiving nebulized medication.

Systems and methods for preparing and dispersing dry powders are disclosed herein. The system includes a powder feeder, a rotating holder or disc configured to receive an input powder from the powder feeder, and one or more ultrasonic transducers. The ultrasonic transducer is configured to create standing waves, which suspend the input powder within a space above the rotating holder disc for collection and subsequent processing and/or use. Also disclosed herein is an adapter configured to fit existing off-the-shelf powder dispensers that includes an ultrasonic transducer configured to suspend an input powder in midair for collection.

A breath actuated nebulizer for administration of an inhaled medication to a patient is provided with a generally cylindrical body in a horizontal orientation to the patient. Within the body is a Venturi configured to nebulizer a liquid medication in a reservoir. Within the body is a shaft integrated with a baffle and diaphragm that slides horizontally in response to the breathing of a patient. During inhalation by the patient, the diaphragm flexes shifting the baffle over the Venturi, allowing nebulization to occur. When the patient exhales, the diaphragm flexes to a default position in which the baffle is distal to the Venturi, thereby stopping the nebulization. The diaphragm is biased to rest in this default position until the patient inhales again.

The invention relates to an internal seal system. The internal seal may be incorporated into a pre-filled, small-volume nebulizer assembly with a T-connector. The small-volume nebulizer may be pre-filled with at least one unit-dose of medicine and hermetically sealed until use by an input port seal and the internal seal. The internal seal may operate as a valve when the assembly is changed into a second configuration.