A droplet delivery device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The droplet delivery device includes a housing, a reservoir, and ejector mechanism, and at least one differential pressure sensor. The droplet delivery device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The droplet delivery device is then actuated to generate a stream of droplets having an average ejected droplet diameter within the respirable size range, e.g, less than about 5 μm, so as to target the pulmonary system of the user.

A device and method for delivering a fluid as an ejected stream of droplets during inhalation uses inertial filtering to cause a first plurality of droplet particles generated by an ejector mechanism to pass through an airflow exit while a second plurality of droplet particles having a greater mass mean aerodynamic diameter than the first plurality of droplet particles fails to pass through the airflow exit.

Systems and methods for preparing and dispersing dry powders are disclosed herein. The system includes a powder feeder, a rotating holder or disc configured to receive an input powder from the powder feeder, and one or more ultrasonic transducers. The ultrasonic transducer is configured to create standing waves, which suspend the input powder within a space above the rotating holder disc for collection and subsequent processing and/or use. Also disclosed herein is an adapter configured to fit existing off-the-shelf powder dispensers that includes an ultrasonic transducer configured to suspend an input powder in midair for collection.

A supplemental oxygen delivery system is described in which Aerosol is delivered into a housing 10, 20, which sits in the circuit from the supplemental oxygen supply and optional humidifier. The supplemental oxygen passes through this chamber 10, 20 in which the aerosol is located, and collects the aerosol transporting it to a patient via a nasal cannula 3 or a face mask 4. An aerosol generator 9 is mounted to the housing 10, 20 and delivers aerosol into an oxygen stream 13 flowing between an inlet 14 and an outlet 15 of the housing 10. The housing 10 also has a removable plug 16 in the base 17 thereof for draining any liquid that accumulates in the housing 10. There is no disruption of oxygen delivery to patients using nasal cannulas who currently have to use a separate face-mask when receiving nebulized medication.

An inhalation device having a reservoir for storing liquid before being discharged, and a discharge head for dispensing the liquid in droplet mist. The discharge head has a nozzle arrangement for generating the droplet mist and housing on which a discharge channel is provided for use as a respiration piece or for attachment of a separate respiration piece. A main axis of extent of the discharge channel encloses an angle of >0° with a central dispensing direction. In alignment with the central dispensing direction of the nozzle arrangement, either an aperture is provided in the housing through which aperture the droplet mist emerges from the discharge head if it is not sucked into the discharge channel by respiration of the user, or a liquid buffer is provided for receiving the droplet mist if it is not sucked into the discharge channel by respiration of the user.

An ejector mechanism, droplet delivery device and related methods or delivering small droplets to the respiratory system of a users disclosed. The ejector mechanism comprises a piezoelectric actuator and an aperture plate, the aperture plate having and a plurality of openings formed through its thickness, wherein at least the fluid entrance side of one or more of said openings is configured to provide a surface contact angle of less than 90 degrees and the piezoelectric actuator is operable to oscillate the aperture plate at a frequency to thereby generate an ejected stream of droplets during use. The droplet delivery device is automatically breath actuated by a user when the differential pressure sensor senses a predetermined pressure change. The ejector mechanism is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range having a diameter of less than about 4 um so as to target the respiratory system of the user.

The invention relates to a nebulization device (1) for medical mixture. It comprises a containing ampoule (2) for medical mixture, comprising an upper component (2a) and a lower component (2b) connected to each other, at least one emission opening (11) of the nebulized medical mixture from the ampoule (2), and at least one entry window (19) for the intake of air within the ampoule (2). Moreover, the nebulization device (1) comprises at least one atomizer (14) for the intake of pressurized gas, within the lower component (2b) of the ampoule (2), the atomizer (14) being surmounted by the upper component (2a). Advantageously, at least one, preferably two selection side windows (24) are provided on the upper component (2a), the opening of the selection side windows (24) being shielded by shielding means (16), moved by a command shaft (17).

An adjustable aerosol delivery device includes an active liquid container, a carrier liquid container, a piezo disc mounted with a flexible gasket relative to the carrier liquid container, an oscillator configured to generate an ultrasonic wave that causes the piezo disc to oscillate and transmit the oscillations through the carrier liquid to the active liquid to cause at least a portion of the active liquid to become an aerosol, a bushing fixed relative to the carrier liquid container via a fixing portion that conforms to and mates with an entire perimeter of a fixing section of the bushing, and a fastener extending through the piezo disc housing and into the bushing. The fastener is configured to be loosened or tightened to manipulate a compression of the gasket to adjust a particle size of the aerosol. A pull force of the bushing is greater than a counter force of the gasket.

An endonasal drug delivery device, suitable for inhalation, includes a shaped body having a first portion located at a first end of the shaped body, configured to be inserted in a nasal cavity and having an air delivery duct, a second intermediate portion having at least one air supply duct for allowing air to flow from the outside to the inside of the endonasal delivery device, and a third portion located at the opposite end of the first portion and having a mixing chamber, which is in fluid communication with the supply duct, a drug reservoir, and the delivery duct.

Methods are provided for acutely treating migraine headache with or without aura. The methods comprise administering to a subject with migraine headache an effective dose of a liquid pharmaceutical composition comprising dihydroergotamine (DHE) or a salt thereof, wherein the dose is administered by an intranasal delivery device that provides, following intranasal administration, (a) a mean peak plasma DHE concentration (C.sub.max) of at least 750 pg/ml, (b) with a mean time to C.sub.max(T.sub.max) of DHE of less than 45 minutes, and (c) a mean plasma AUC.sub.0-inf of DHE of at least 2500 pg*hr/ml. Also provided are kits for acutely treating migraine with or without aura in which a liquid pharmaceutical composition comprising DHE or DHE salt is contained within a sealed vial that is attachable to a precision intranasal olfactory delivery device packaged therewith.