A delivery device for and method of delivering a powdered substance, in particular a triptan, such as sumatriptan, to the posterior region of a nasal cavity of a subject, in particular for the treatment of headaches, for example, cluster headaches and migraine, and neuropathic pain, the delivery device comprising: a nosepiece for insertion into a nasal cavity of a subject through which the powdered substance is delivered to the posterior region of the nasal cavity of the subject, in particular the upper posterior two thirds of the nasal cavity; and a substance supply unit which is operable to deliver the powdered substance through the nosepiece.

A dry powder inhaler for providing pharmaceutically active particles includes a mouthpiece portion removably coupled to a distal end portion. The mouthpiece portion extends between the mouthpiece end and a first mating end. The distal end portion extends between a second mating end and the distal end. A capsule cavity is defined within the first mating end. An airflow element is disposed within the distal end portion and extends a longitudinal length to the capsule cavity. The airflow element includes an airflow channel extending the longitudinal length of the airflow channel and non-parallel with the longitudinal axis, the airflow channel directs inlet air into the capsule cavity, and a resealable membrane configured to reseal when a piercing element is withdrawn from the resealable membrane.

The present disclosure provides systems and methods for delivering a gel to a surface. In one embodiment, the system may have a first vessel with a first low viscosity aqueous solution comprising a binder/crosslinking agent; and a second vessel with a second low viscosity aqueous solution comprising a gelling component. The separate first and second low viscosity aqueous solutions are sprayed onto a surface where the solutions mix forming a gel.

The present disclosure provides systems and methods for disrupting the outer membrane of an oocyst in solution and delivering the solution to an animal. The system includes a vessel containing unbroken oocysts in solution, an oocyst processing chamber, and a delivery outlet. The unbroken oocysts are moved from the vessel through the processing chamber and a portion of the oocyst membranes are disrupted releasing sporocysts, the resulting solution is moved from the processing chamber into the delivery outlet where the solution is delivered to an animal. Methods of vaccination, including vaccination against an Eimeria infection, are also provided.

A laser heater assembly for a vaporizer includes a power source, a laser source, a lens, and a reaction chamber. The lens is disposed within the optical path. During operation, the laser source emits light, the light propagating along an optical path during operation of the light source. The lens receives the emitted light from the laser source, and outputs a modified light having an energy profile that is substantially spatially uniform. The modified light traverses at least a portion of an opening of the reaction chamber and vaporizes a vaporization substance (e.g., a dry plant material) received within the reaction chamber. The emitted light can be collimated light, and the modified light can be a homogeneous line profile beam.

An electronic inhaler having an embedded system and a method for precise and repeatable delivery of multiple types of medications in different forms to the pulmonary system of a human user. The inhaler can include a housing defining an internal chamber for accommodating at least two cartridges (reservoirs) containing multiple medicines in different states, and a meter reservoir compartments that can automatically provide precise doses of medicine using vacuum pressure sensors. The sensors can be in communication with the internal embedded system/electronics (microcontroller) of the inhaler and the electronics/microcontroller can be in permanent communication with a software application running on the user's smart phone or other electronic device.

An automated drug delivery and monitoring system for use on mechanically ventilated patients in the intensive care unit is presented. Medication in the form of respirable particles is transported through ventilator circuitry by a delivery unit. Multiple medications may be delivered into the gas flow of the ventilator, with each medication delivered in a defined dose for a frequency and interval as specified by an operator. The particles mixed into the gas flow of the ventilator are inhaled and ingested by the patent's lungs.

A laser heater assembly for a vaporizer includes a power source, a laser source, a lens, and a reaction chamber. The lens is disposed within the optical path. During operation, the laser source emits light, the light propagating along an optical path during operation of the light source. The lens receives the emitted light from the laser source, and outputs a modified light having an energy profile that is substantially spatially uniform. The modified light traverses at least a portion of an opening of the reaction chamber and vaporizes a vaporization substance (e.g., a dry plant material) received within the reaction chamber. The emitted light can be collimated light, and the modified light can be a homogeneous line profile beam.

An inhaler article includes a body extending from a mouthpiece end to a distal end with an endpiece element at the distal end. A capsule cavity is defined within the body and extends a cavity length. An air inlet region is between the endpiece element and the capsule cavity. The air inlet region has an air inlet and an air passageway extending from the air inlet to the capsule cavity. The air passageway has an inner diameter less than an inner diameter of the capsule cavity. A porous support element defines a downstream end of the capsule cavity. The porous support element includes one or more apertures extending the length of the porous support element.

A laser heater assembly for a vaporizer includes a power source, a laser source, a lens, and a reaction chamber. The lens is disposed within the optical path. During operation, the laser source emits light, the light propagating along an optical path during operation of the light source. The lens receives the emitted light from the laser source, and outputs a modified light having an energy profile that is substantially spatially uniform. The modified light traverses at least a portion of an opening of the reaction chamber and vaporizes a vaporization substance (e.g., a dry plant material) received within the reaction chamber. The emitted light can be collimated light, and the modified light can be a homogeneous line profile beam.