A medication inhalation apparatus preferably formed of a single, unitary sheet of stock, includes an outer housing, movable between collapsed and expanded states, encompassing a first volume. An inner housing within the outer housing encompasses an inner or second volume. An inhaler opening to the first volume is within a wall of the outer housing at a first location. A mouth opening to the inner volume is within a wall of the outer housing and the inner housing at a second location. A one-way inhalation valve connecting the first volume and the inner volume is within a wall of the inner housing. A one-way exhalation valve connecting the inner volume and the exterior of the outer housing is within a wall of the outer housing and inner housing at a third location. The valve preferably includes an elongated spring body formed of a semi-pliant material with a strength and rigidity providing limited flexibility. A first separation is perpendicular to the elongate axis of the spring body, and extends from a first edge of the spring body across at least a portion of a width of the spring body. A second separation perpendicular to the elongate axis of the spring body extends from a second edge of the spring body across at least a portion of the width of the spring body.

A nebulizer device aerosolizes (or vaporizes) liquid drawn from a liquid reservoir via a fluid flow path into a nebulization chamber. An inlet port is coupled to an external air supply and leads through a check valve and Venturi nozzle (e.g. a duckbill valve) into the chamber to direct an air stream across an opening of the fluid flow path. A discharge port leads from the chamber to a user mask, mouthpiece or canula, where the aerosol or vapor mixture can be inhaled. A filtered outlet port isolates exhaled material from the external environment. Multiple discrete heating elements may be placed around the fluid flow path to preheat the liquid. If the liquid is sufficiently volatile, heating may vaporize the material which can condense back into an aerosol after mixing with the air stream. A set of check valves direct one-way fluid flow and prevent leakage or spillage of material from the device.

Disclosed herein is a nebulizer comprising of a medicine cup reservoir containing an aqueous pirfenidone solution a medicine cup reservoir cap, an aerosol generator, an aerosol mixing chamber to which freshly generated aerosol resides until inhaled, a one-way inhalation valve, a mouthpiece and a one-way exhalation valve. The invention allows atmospheric pressure to be maintained inside the medicine cup reservoir during nebulization and optimizes the volume of the aerosol mixing chamber to minimize freshly generated aerosol inter-droplet collision, impaction of aerosol to the aerosol mixing chamber wall, droplet growth and/or condensation during exhalation, prior to inhalation, or during inhalation. The larger aerosol mixing chamber volume also allows the aerosol to accumulate during the exhalation phase. Despite venting producing a larger generated aerosol droplet population mean compared to the non-vented aerosol generator, The combined effect of the invention increases device output rate of respirable aerosol droplets, increases pirfenidone Cmax and AUC to improve treatment or prevention of various diseases, including disease associated with the lung, heart and kidney, including fibrosis, inflammatory conditions and transplant rejection.

An inhaler, preferably for insertion into a nostril, in particular a horse's nostril, with a pressure generator, which has a tensioning device for the drive, and with a tensioning mechanism for tensioning the tensioning device, whereby the tensioning mechanism has a lever gear for tensioning the tensioning device.

The present invention provides a new inhaler device for the storage and/or administration of inhalable liquids to a patient offering one or more advantages or improvements over known inhalers, particularly inhalers for the delivery of halogenated volatile liquids such as methoxyflurane for use as an analgesic.

A medication delivery system having a holding chamber capable of delivering dosages of medicament from a metered dose inhaler. The holding chamber includes an actuator detector, flow detector and display. In another embodiment, a medication delivery system includes a holding chamber having an input and an output end, a metered dose inhaler operably coupled to the input end of the holding chamber, and a metered dose inhaler identifier associated with the holding chamber and operable to identify the metered dose inhaler coupled to the holding chamber.

A smoking pipe has a a combustion bowl, a mouthpiece, and an inhalation conduit. An inhalation check valve is connected to the inhalation conduit and positioned between the bowl and the mouthpiece, oriented to pass smoke of combustion in one direction from the bowl to the mouthpiece. An exhalation check valve is positioned between the mouthpiece and the atmosphere, and is oriented to pass exhalation in one direction from the mouthpiece to the atmosphere. A body is partially fillable to retain water, and the inhalation conduit passes from the bowl into the body and extends to an upper area inside the body, and then turns to extend towards a lower area inside the body, terminating in an open end. The inhalation conduit has a second portion that has an opening in the upper inner area and extends to the inhalation check valve.

A breath-enhanced jet nebulizer is configured with a low liquid retention reservoir and a narrow liquid delivery passage to efficiently and efficiently aerosolize small drug volumes with minimal waste. Aerosol particles are directed through aerosol passage for delivery, although larger liquid particles are directed away from the aerosol outlet and recycled to the liquid reservoir.

A personalized drug delivery apparatus comprising drug containing means; a spout configured to receive full lung exhalation; a mechanism configured to determine a personalized drug dosage according to the exhalation, the spout further configured to enable inhalation of the determined dosage.

A delivery device for use in administering a dry powder to a biological subject's airway is provided. The device comprises (a) a housing having an inlet in fluid communication with an outlet for delivering a flow of gas to the subject's airway; and (b) one or more cantilever structures located within the housing. Vibration of the one or more cantilever structures facilitates entry of the dry powder into the flow of gas, such that the dry powder can be delivered by the flow of gas through the outlet to the subject's airway. Also provided is a container for releasably storing a particulate composition, the container comprising a shell sealed by a seal in which the particulate composition is stored, wherein a puncturing device for rupturing the seal to release the particulate composition is housed within the shell. Further provided are associated methods for administering dry powder using the delivery device and/or container.