A mask includes a body having an interior surface defining a cavity shaped to receive a user's nose. An exterior surface of the body is exposed to an ambient environment. The body includes an inlet in fluid communication with the cavity and a one-way exhaust valve in fluid communication between the cavity and the ambient environment. A therapeutic substance dispenser is in fluid communication with the cavity. In one embodiment, a nasal aromatic decongestant is disposed in the therapeutic dispenser. A mask includes an upper nasal cavity separate from a lower oral cavity, with an inlet in fluid communication with only the upper nasal cavity. A medicament delivery assembly, and methods for the use thereof, are also provided.

A method of delivering a substance, such as fluticasone propionate, a nasal steroid and/or carbon dioxide gas, to the nasal cavity of a subject, in particular for the treatment of sinus and/or nasal inflammatory diseases, for example, chronic rhinosinusitis with or without nasal polyps, to reduce sinus inflammation, reduce sinus opacification, and/or improve associated symptoms.

Disclosed herein are formulations of pirfenidone or pyridone analog compounds for aerosolization and use of such formulations for aerosol administration of pirfenidone or pyridone analog compounds for the prevention or treatment of various fibrotic and inflammatory diseases, including disease associated with the lung, heart, kidney, liver, eye and central nervous system. In some embodiments, pirfenidone or pyridone analog compound formulations and delivery options described herein allow for efficacious local delivery of pirfenidone or pyridone analog compound. Compositions include all formulations, kits, and device combinations described herein. Methods include inhalation procedures, indications and manufacturing processes for production and use of the compositions described.

A nebulizer has a body, a fluid reservoir, and a flutter valve. The body has a first end that has a mouthpiece, a second end, an aerosol delivery channel extending though the body from the first end to the second end, and a fluid reservoir receiving compartment in communication with the aerosol delivery channel. The fluid reservoir is positioned in the fluid reservoir receiving compartment. The fluid reservoir contains a volume of fluid and has a vibrating mesh disc for delivering the fluid to the aerosol delivery channel in an aerosol form upon the vibrating mesh disc being energized. The flutter valve is positioned in the aerosol delivery channel of the body near the second end of the body. The flutter valve is moveable between a closed position and an open position when the expiratory pressure greater than a predetermined expiratory pressure is exerted on the flutter valve.

A nebulizer kit includes: a housing body that houses an atomization portion configured to atomize a liquid and includes a first opening portion and a second opening portion; and a mouthpiece in which a first attachment portion including a first check valve and configured to be attachable to and detachable from the first opening portion and a tubular second attachment portion including a second check valve and configured to be attachable to and detachable from the second opening portion are integrally configured. An inhalation attachment different from the mouthpiece is attachable to the second opening portion in a state in which the mouthpiece is removed from the housing body.

Described herein are devices, systems and methods for monitoring the use of a nebulized medication, such as can be administered using a nebulizer. These can be used for monitoring a patient undergoing treatment for COPD and improve compliance to the recommended therapy. Monitored parameters include flow, humidity and acceleration and provide data as to the quantity and quality of nebulizer use.

A nasal delivery device for and method of delivering particulate substance to the nasal airway of a subject, the delivery device comprising: a body assembly including a mouthpiece unit which includes a mouthpiece through which the subject in use exhales, and a substance-supply unit which is fluidly connected to the mouthpiece unit and actuatable to provide particulate substance for delivery to the nasal airway of the subject; wherein the body assembly is configured to receive a replaceable nosepiece unit which includes a nosepiece and contains a container containing particulate substance.

An inhaler with an evaluation unit, a housing with a mouthpiece and a chamber with a container unit. Provided between the container unit and a chamber wall is an annular gap, through which air is sucked in and mixes with medium flowing through a discharge. The evaluation unit is mounted on the container unit and is pressed down together with a container of the container unit and detects air sucked through the annular gap. A measuring channel forms part of a first flow path for air flowing into the chamber from a surrounding area and a flow sensor detects the air flowing through the measuring channel. A second flow path is provided for air flowing into the chamber from a surrounding area, the flow resistance of which second path is equal to or lower than that of the first flow path.

The invention relates to a nebulization device (1) for medical mixture. It comprises a containing ampoule (2) for medical mixture, comprising an upper component (2a) and a lower component (2b) connected to each other, at least one emission opening (11) of the nebulized medical mixture from the ampoule (2), and at least one entry window (19) for the intake of air within the ampoule (2). Moreover, the nebulization device (1) comprises at least one atomizer (14) for the intake of pressurized gas, within the lower component (2b) of the ampoule (2), the atomizer (14) being surmounted by the upper component (2a). Advantageously, at least one, preferably two selection side windows (24) are provided on the upper component (2a), the opening of the selection side windows (24) being shielded by shielding means (16), moved by a command shaft (17).

Described herein are devices, systems and methods for monitoring the use of a nebulized medication, such as can be administered using a nebulizer. These can be used for monitoring a patient undergoing treatment for COPD and improve compliance to the recommended therapy. Monitored parameters include flow, humidity and acceleration and provide data as to the quantity and quality of nebulizer use.