A breathing mask for use in administering inhalable medications to a patient in need of an inhaled drug is provided. The mask disclosed herein is particularly useful for use with very young children. The mask is made from a flexible molded plastic silicone or elastomeric material, and has an anthropometrically/anatomically/ergonomically contoured shape to provide a good seal, a comfortable fit, and minimal dead space within the mask. The airway is aligned with nose. There may be an orifice for use with a soother device to calm a child using the mask. Also provided is a visual flow indicator to provide an indication of the quality of the seal of the mask on the face.

The present disclosure relates to a pharmaceutical composition comprising an inhalable immunosuppressive macrocyclic active ingredient for use in the prevention or treatment of a pulmonary disease or condition in a subject, wherein the pharmaceutical composition is administered to the subject by inhalation in form of an aerosol, and wherein the aerosol is generated by nebulization of the pharmaceutical composition using a nebulizer (100), the nebulizer comprising: a) an aerosol generator (101) comprising: —a fluid reservoir (103) for holding the pharmaceutical composition or an interface configured to connect a fluid reservoir, and —a vibratable membrane (110) having a plurality of apertures, the apertures being adapted to produce an aerosol comprising droplets having a mass median aerodynamic diameter (MMAD) of up to about 15 4.0 μm as measured with a 0.9% (w/v) aqueous solution of sodium chloride; b) a chamber (105) for temporarily accommodating the aerosol generated by the aerosol generator (101), the chamber having an inner lumen with a volume in the range of from about 50 to about 150 ml; and c) a mouthpiece (40) for delivering the aerosol supplied by the nebulizer (100) to the subject, the mouthpiece having an exhalation filter (30).

A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece (117) for fitting to a nasal cavity of a subject; a mouthpiece (119) into which the subject in use exhales; a delivery unit, which comprises an actuation part which is manually displaceable to actuate the delivery unit to deliver substance from the nosepiece; and a valve assembly (127) which is fluidly connected to the nosepiece and the mouthpiece, wherein the valve assembly comprises a body element (128) and a valve element (131) which is movably disposed to the body element between closed and open configurations by manual displacement of the actuation part of the delivery unit to provide for an air flow through the nosepiece simultaneously with delivery of substance.

A medication delivery system having a holding chamber capable of delivering dosages of medicament from a metered dose inhaler. The holding chamber includes an actuator detector, flow detector and display. In another embodiment, a medication delivery system includes a holding chamber having an input and an output end, a metered dose inhaler operably coupled to the input end of the holding chamber, and a metered dose inhaler identifier associated with the holding chamber and operable to identify the metered dose inhaler coupled to the holding chamber.

The invention relates to a nebulization device (1) for medical mixture, of the type comprising: a containing ampoule (2) for medical mixture, comprising an upper component (2a) and a lower component (2b) connected to each other; at least one emission opening (11) of said nebulized medical mixture from the ampoule (2), and at least one entry window (19) for the intake of air within said ampoule (2); as well as at least one atomizer (14) for the intake of pressurized gas, within the lower component (2b) of the ampoule (2), the atomizer (14) being surmounted by the upper component (2a). Advantageously, at least one, preferably two selection side windows (24) are provided on the upper component (2a), the opening of said selection side windows (24) being shielded by shielding means (16), moved by a command shaft (17).

A medication delivery system having a holding chamber capable of delivering dosages of medicament from a metered dose inhaler. The holding chamber includes a first housing component having a user interface with an outlet opening and a second housing component having an inlet opening spaced apart from the outlet opening of the first housing component. The first housing component is pivotally connected to the second housing component about a pivot axis.

A cartridge is inserted onto a nebulizer that aerosolizes (or vaporizes) liquid drawn from a cartridge reservoir via a flow path into a nebulization chamber. In such a nebulizer, an inlet port is coupled to an external air supply and leads through a Venturi nozzle into the chamber to direct an air stream across an opening of the flow path, while a discharge port leads from the chamber to a user mask, mouthpiece or cannula, where the aerosol or vapor mixture can be inhaled. A filtered outlet port isolates exhaled material from the external environment. Multiple discrete heating elements may be placed around the flow path to preheat the liquid. If the liquid is sufficiently volatile, heating may vaporize the material which can condense back into an aerosol after mixing with the air stream. A set of check valves direct one-way flow and prevent leakage or spillage of material from the cartridge or nebulizer. The cartridge and nebulizer can receive coded information for third-party activation by an authorized establishment.

A nebulizer device aerosolizes (or vaporizes) liquid drawn from a liquid reservoir via a fluid flow path into a nebulization chamber. An inlet port is coupled to an external air supply and leads through a check valve and Venturi nozzle (e.g. a duckbill valve) into the chamber to direct an air stream across an opening of the fluid flow path. A discharge port leads from the chamber to a user mask, mouthpiece or canula, where the aerosol or vapor mixture can be inhaled. A filtered outlet port isolates exhaled material from the external environment. Multiple discrete heating elements may be placed around the fluid flow path to preheat the liquid. If the liquid is sufficiently volatile, heating may vaporize the material which can condense back into an aerosol after mixing with the air stream. A set of check valves direct one-way fluid flow and prevent leakage or spillage of material from the device.

An inhaler device for the delivery of an inhalable liquid to a patient includes an inhaler body, at least one air inlet opening, at least one vapor inhalation opening, and a storage sachet located within the inhaler body. The storage sachet includes a vapor impermeable film or foil for sealingly storing a passive evaporation support material pre-loaded with the inhalable liquid. The stored liquid is configured to be released from the storage sachet into the inhaler body in the form of a vapor when the sachet is opened and further wherein the air inlet opening and vapor inhalation opening provide an air/vapor pathway through the inhaler body. The storage sachet includes a pull tab that protrudes through an opening in the inhaler body and configured such that the pull tab can be gripped and pulled by the user to open the storage sachet.

A handheld digital nebulizer device and related methods for delivering precise and repeatable dosages to a subject for pulmonary use is disclosed. The handheld digital nebulizer device includes a housing having an exhalation valve, a reservoir, an ejector mechanism, and at least one differential pressure sensor. The handheld digital nebulizer device is automatically breath actuated by the user when the differential pressure sensor senses a predetermined pressure change within housing. The handheld digital nebulizer device is then actuated to generate a plume of droplets having an average ejected particle diameter within the respirable size range, e.g, less than about 5-6 μm, so as to target the pulmonary system of the user.