A fluid dispenser device having a dispenser head; an air expeller; and a reservoir containing a single dose of fluid. The reservoir includes a proximal axial end and a distal axial end, and is removably mounted so that after the device has been actuated, the empty reservoir can be removed from the device and replaced by a new full reservoir. The air expeller is adapted to return to its rest position to enable a new actuation with the new full reservoir. The dispenser head includes a proximal perforator tip to perforate the proximal axial end of the reservoir. The device includes a movable perforator member that slides axially around the dispenser head between a loading position and an actuation position and includes a distal perforator tip adapted to perforate the distal axial end of the reservoir when the movable perforator member is moved into its actuation position.

Exemplary embodiments include dry powder inhalers (DPIs) and patient interfaces which improve delivery of aerosols to patients, especially children.

The present invention relates to an inhalation device (1), to the use thereof, and to a kit comprising the inhalation device. The inhalation device (1) has an air inlet (14), an air outlet (15) designed as a mouthpiece or nosepiece, and a recess (17) which is designed to receive a container (2) with an inhalable substance. An air duct (L) extends from the air inlet (14) through the recess (17) to the air outlet (15). Moreover, the inhalation device (1) has at least one hollow mandrel (16, 16′) which protrudes into the recess (17) and from which at least one air delivery line (14′, 14″) extends to the air inlet (14) or at least one air outlet line (15′) extends to the air outlet (15). The inhalation device (1) is characterized in that the inhalation device (1) has two limbs (11, 12), each with a work end (11′, 12′) and with an actuation end (11″, 12″), wherein the limbs (11, 12) are connected by means of a joint (13) which lies between the work ends (11′, 12′) and the actuation ends (11″, 12″). Furthermore, the recess (17) is defined between the mutually facing sides of both limbs (11, 12) at the work ends (11′, 12′), wherein the at least one hollow mandrel (16, 16′) is arranged inside the recess (17) on one of the mutually facing sides of both limbs (11, 12). The air inlet (14) and the air outlet (15) are arranged at the work end (11′, 12′) on a side, directed away from the recess (17), of at least one of the limbs (11, 12).

An inhaler article includes a body extending along a longitudinal axis from a mouthpiece end to a distal end and a capsule cavity defined within the body. The capsule cavity has a length extending along the longitudinal axis. A mouthpiece air channel extends from the capsule cavity to the mouthpiece end. An end cap is disposed within the distal end and extends to the capsule cavity. The end cap includes an air channel extending from the end cap distal end to the end cap inner end. A capsule is disposed within the capsule cavity and has a capsule length. The capsule length is in a range from about 25% to about 99% of the cavity length, or about 50% to about 95% of the cavity length, or about 70% to about 90% of the cavity length, or from about 75% to about 85% of the cavity length, or about 80% of the cavity length.

Provided is a system (10) for determining a probability of an asthma exacerbation in a subject. The system comprises an inhaler (100) for delivering a rescue medicament to the subject. The inhaler has a use-detection system (12B) configured to determine a rescue inhalation performed by the subject using the first inhaler. A sensor system (12A) is configured to measure a parameter relating to airflow during the rescue inhalation. The system further comprises a processor (14) configured to determine a number of the rescue inhalations during a first time period, and receive the parameter measured for at least some of the rescue inhalations. The processor determines, using a weighted model, the probability of the asthma exacerbation based on the number of rescue inhalations and the parameters.

The model is weighted such that the number of rescue inhalations is more significant in the probability determination than the parameters.

The present invention relates to a kit comprising: a) an ampoule; b) a material comprising a hemp plant or parts thereof; and c) a color indicator capable of reacting by contacting the hemp plant and/or at least a part thereof to change the color of the color indicator, wherein the material and the color indicator are disposed in the ampoule; and a method for qualitatively and/or quantitatively detecting one or more substance(s) contained in the hemp plant using the kit.

A device, system, and method for vaporizing substances in a pod or a cartridge, utilized for inhalation by a user. The device includes components to measure the content and dosage pods or cartridges containing substances, among other features. The device includes a graphical user interface that may be integrated with the device or implemented through a mobile device, which allows the user to transmit user data to a remote database and/or healthcare provider for personal and clinical data collection. The user data can be used for enhancing personal treatment or clinical research.

A device, system, and method for vaporizing substances in a pod, utilized for inhalation by a user. The device includes components to measure the content and dosage pods containing substances, among other features. The device includes a graphical user interface that may be integrated with the device or implemented through a mobile device, which allows the user to transmit user data to a remote database and/or healthcare provider for personal and clinical data collection. The user data can be used for enhancing personal treatment or clinical research.

This invention relates to a fixed-dose dry powder inhalation formulation comprising fluticasone propionate and albuterol sulfate, together with an α-lactose monohydrate carrier. In the formulation, the albuterol sulfate stabilises fluticasone propionate.

The method includes defining a cavity within a housing of a vapor-generating article, the vapor-generating article having a first end, a second end and a middle section, first inserting at least one portion of a retention medium within the housing between the first end and the middle section, and second inserting a first frangible capsule to be near or at least partially within the retention medium, the first frangible capsule including a first volatile substrate.