A device for dispensing individual doses of powder from respective pockets of a disc-shaped carrier by outwardly rupturing a lidding foil by means of pressure on an opposite side surface, the device providing individual respective deaggregation flow paths for each pocket, split airstreams allowing improved entrainment of powder, a cam mechanism for outwardly rupturing the pockets, an indexing mechanism linked to the cam mechanism and a dose counter.

A device for delivering a predetermined volume a substance within a body cavity. The device includes: at least one predefined volume sized and shaped to contain a predetermined volume the substance; a delivery end in fluid communication with a container; and at least one valve mechanically connected to the container and configurable between an active configuration in which the valve enables delivery of a volume of the substance and an inactive configuration, in which the valve prevents delivery.

The present application provides a priming member for an inhaler and a method of loading an inhaler with a carrier for treating a respiratory disease by inhaling a powder from the inhaler. The priming member comprises a cantilever blade configured to engage a chassis of the inhaler, the cantilever blade having a proximal portion, a body and a distal portion, the body being disposed between the proximal portion and the distal portion of the cantilever blade and the cantilever blade having a flexible portion extending with the proximal portion of the cantilever blade to allow movement of the cantilever blade relative to the chassis.

A dispenser device having a dispenser head; an air expeller (20) for generating a flow of air with a piston (21) that slides in an air chamber (22); and a reservoir (30) containing a dose of composition, the reservoir (30) including an air inlet (31) connected to the air expeller (20), and a composition outlet (32) connected to the dispenser outlet (10), the air inlet (31) including a composition retainer member (40), and the composition outlet (32) closed by a closure element (50). The device has an opening system (61, 62) and an indicator (100; 50) that before actuation is in a first state and after actuation passes into a second state. The device includes a pusher element (25) secured to the piston (21). The dispenser head (1) includes a skirt (5) arranged around the air chamber (22), the bottom axial edge of the skirt (5) including a cutout (6).

A dispenser device for dispensing a fluid or powder composition, the dispenser device comprising: a dispenser head (1) that is provided with a dispenser outlet (10) that is formed at the end of a hollow sleeve (3); an air expeller (20) for generating a flow of air while the device is being actuated, said air expeller including a piston (21) that slides in an air chamber (22) between a rest position and a dispensing position, said air chamber (22) including a cylindrical body in which said piston (21) slides in airtight manner; and a reservoir (30) that contains a single dose of composition, said reservoir (30) including an air inlet (31) that is connected to said air expeller (20), and a composition outlet (32) that is connected to said dispenser outlet (10), said air inlet (31) including a composition retainer member (40) for retaining the composition in the reservoir (30) until the composition is dispensed, and said composition outlet (32) being closed by a closure element (50) that is force fitted in the composition outlet (32) of the reservoir (30); said device further comprising a mechanical opening system (61, 62) that co-operates with said closure element (50) so as to expel it mechanically from its closed position while the device is being actuated; said device further comprising an indicator (100; 50) that, in the rest position before actuation, is in a first state, and that after actuation passes into a second state, the passage from the first to the second state informing the user that the device has been actuated, said first state being a visible state and said second state being a non-visible state, said device including a pusher element (25) that is secured to said piston (21), and on which the user presses during actuation, said dispenser head (1) including a skirt (5) that is arranged around said air chamber (22), said pusher element (25), in its rest position before actuation, projecting axially out from said skirt (5), and after actuation, being arranged inside said skirt (5), said pusher element (25) including an indicator (100) that is visible before actuation and that is not visible after actuation.

A dispenser device for dispensing a fluid or powder composition, the dispenser device comprising: a dispenser head (1) that is provided with a dispenser outlet (10) that is formed at the end of a hollow sleeve (3); an air expeller (20) for generating a flow of air while the device is being actuated, said air expeller including a piston (21) that slides in an air chamber (22) between a rest position and a dispensing position, said air chamber (22) including a cylindrical body in which said piston (21) slides in airtight manner; and a reservoir (30) that contains a single dose of composition, said reservoir (30) including an air inlet (31) that is connected to said air expeller (20), and a composition outlet (32) that is connected to said dispenser outlet (10), said air inlet (31) including a composition retainer member (40) for retaining the composition in the reservoir (30) until the composition is dispensed, and said composition outlet (32) being closed by a closure element (50) that is force fitted in the composition outlet (32) of the reservoir (30); said device further comprising a mechanical opening system (61, 62) that co-operates with said closure element (50) so as to expel it mechanically from its closed position while the device is being actuated; said device further comprising an indicator (100; 50) that, in the rest position before actuation, is in a first state, and that after actuation passes into a second state, the passage from the first to the second state informing the user that the device has been actuated, said first state being a visible state and said second state being a non-visible state, said device including a pusher element (25) that is secured to said piston (21), and on which the user presses during actuation, said dispenser head (1) including a skirt (5) that is arranged around said air chamber (22), said pusher element (25), in its rest position before actuation, projecting axially out from said skirt (5), and after actuation, being arranged inside said skirt (5), said pusher element (25) including an indicator (100) that is visible before actuation and that is not visible after actuation.

A dispenser device having a dispenser head; an air expeller (20) for generating a flow of air with a piston (21) that slides in an air chamber (22); and a reservoir (30) containing a dose of composition, the reservoir (30) including an air inlet (31) connected to the air expeller (20), and a composition outlet (32) connected to the dispenser outlet (10), the air inlet (31) including a composition retainer member (40), and the composition outlet (32) closed by a closure element (50). The device has an opening system (61, 62) and an indicator (100; 50) that before actuation is in a first state and after actuation passes into a second state. The device includes a pusher element (25) secured to the piston (21). The dispenser head (1) includes a skirt (5) arranged around the air chamber (22), the bottom axial edge of the skirt (5) including a cutout (6).

A device for inhaling an active agent is provided that can be moved from a first configuration to a second configuration. The device comprises two flexible substrates and a membrane located between the two flexible substrates, and the two flexible substrates being connected at two opposing edges and unconnected at two further opposing edges. An active agent provided on the membrane may be inhaled by a user when the device is in the second configuration. A method of using the device is also provided.

A nozzled cartridge (20) for storing medicine, according to an aspect of the present application, includes a medicine container (21) that is to be filled with a predetermined quantity of a powdered medicine, a nozzle portion (22) that is formed on the medicine container (21) and that ejects the powdered medicine, a closing member (24) that closes an opening (22a) in the nozzle portion (22), and a valve member (25) that functions as a plug to close another opening (23a) in the medicine container (21), and that is opened when administering medicine. The nozzled cartridge (20) is detachably mountable to a sprayer (30) when administering medicine.

The multi-chambered well dosage form and device disclosed herein can be single or multi dose capable for administration of pharmaceuticals of a range of particle sizes. The present dosage devices and systems provide for improved efficiency and patient ease of use owing to its compact size and simple design, low cost, and consistent, contamination free dosing of dry powder medicaments or other agents. The present disclosure provides a multi-chambered dosage form containing dry powder medical composition containing chamber well with an internal piercing device and one or more adjacent gas-filled chamber wells to aid the dispense of the powder contents to the user and in certain embodiments, without the requirement of an external energy sources common with active devices known in the art. Said methods, systems and devices provide increased ejection fraction and hence greater efficiency of drug delivery above that as provided by current devices.