An inhaler includes a casing including a first end wall, a second end wall formed opposite to the first end wall, and a side wall formed between the first end wall and the second end wall, a mouthpiece disposed adjacent to the first end wall of the casing, and a cartridge disposed adjacent to the mouthpiece, in which the cartridge may include a rotation screw.

An inhaler includes a housing having one surface, the other surface opposite to the one surface, and a plurality of side surfaces connecting the one surface and the other surface, a mouthpiece which is disposed on the one side of the housing, a reservoir which is disposed inside the housing and stores an inhalable composition, a nozzle which extends from the mouthpiece to the reservoir, and a needle valve which is movably disposed inside the nozzle, when a suction force is not applied to the mouthpiece, the needle valve is maintained in a first state in which the nozzle is closed, and when a suction force is applied through the mouthpiece, the needle valve is switched into a second state in which the nozzle is opened.

Provided is a system for determining a probability of a respiratory disease exacerbation in a subject. The system comprises an inhaler arrangement for delivering a medicament to the subject. The medicament may be a rescue medicament and/or a maintenance medicament. The inhaler arrangement has a use-detection system configured to determine an inhalation performed by the subject using the inhaler arrangement. A sensor system is configured to measure a parameter relating to airflow during the inhalation. A user interface enables user-input of an indication of a status of the respiratory disease being experienced by the subject. A processor is configured to determine the probability of the respiratory disease exacerbation based on the recorded inhalation(s) from the use-detection system, the parameter(s) received from the sensor system, and the indication received from the user interface. Further provided is a method for determining the probability of a respiratory disease exacerbation in a subject.

The present invention provides a cannabinoid inhaler, compositions, and methods for delivering a cannabinoid composition to a subject. The cannabinoid composition is delivered in the form of inhaled droplets of respirable size via pulmonary administration. The invention may be used in the treatment of a condition or disorder selected from the group consisting of neuropathic pain, cannabis addiction, nausea, motion sickness, arthritis, and neurodegenerative disease.

This invention relates to an inhaler with a respiration indicator, whereby the inhaler has a chamber wall forming a chamber and a dispensing device for fluidic connection of the chamber to a bodily opening, preferably a nostril, whereby the respiration indicator has a wall section of the chamber wall or is formed in this way, whereby the wall section is designed to indicate a respiratory activity by deformation and/or movement.

A method of delivering a therapeutic agent comprises providing an aerosol generator that produces an aerosol of particles or droplets containing a therapeutic agent and an excipient for delivery to a first portion of a respiratory tract. The particles or droplets have an initial diameter from about 1 m to about 8 m, and the initial momentum of the particles or droplets minimizes deposition in the first portion. The particles or droplets are exposed to relative humidity in the respiratory tract by delivering them at a flow rate that defines the residence time in the respiratory tract. The particles or droplets increase in diameter due to hygroscopic growth caused by relative humidity. The aerosol is nasally exhaled so that particles or droplets are delivered to the nasal cavity and deposited in the nasal turbinates or sinus in part because of their increased diameter.

A device having a body (10), a reservoir (100) mounted to slide axially relative to the body, a metering valve (200) on the reservoir (100), a blocking element (500), a trigger element (600), an inhalation-controlled trigger system (60) cooperating with the trigger element, an actuating member (800) cooperating with the blocking element, a cover (11) fixed on the body, a push member (810) fastened tot actuating member (800) and mounted to slide axially in the cover, and a spring (850) between the cover and the push member. Before inhalation, the push member is out of contact with the reservoir, such that the force exerted on the push member by the spring is not transmitted to the reservoir, and during inhalation, the push member moves axially with the actuating member so as to come into contact with the reservoir and move it axially in the body to actuate said valve.

A simulated smoking device (1) comprising a simulated cigarette having a substantially cylindrical cigarette-like shape and a refill device (2, 50) having a substantially cuboid housing with a cigarette pack-like shape containing refill gas (32, 59) for the simulated cigarette and having means for selectively retaining the simulated cigarette. The simulated cigarette may be retained wholly within the housing. It may be retained at a location different from the refill location. A dose counter may be provided to give a visual indication of the doses in the refill device.

An inhaler, preferably for insertion into a nostril, in particular a horse's nostril, with an inhalation valve, which has a movable valve element, whereby the valve element is designed in an annular manner and has an outer edge and an inner edge, whereby the valve element is fastened at the outer edge, the inner edge forms the boundary of an indentation of the valve element, and the inhalation valve has a valve body seat that corresponds to the inner edge.

An aerosol dispensing device comprises a tubular body that provides a plenum, a mouthpiece having an outlet, a valve for dispensing fluid from a canister as an aerosol with relatively large and small droplet sizes into the plenum for supply to a user through the mouthpiece, and a baffle arrangement that provides first and second passageways each coupled at one end to the plenum and so configured in the mouthpiece to supply the small size droplets to the user, and the other end of the second passageway being closed to inhibit passage of the large size droplets to the mouthpiece outlet, and containing an absorbent pad to prevent leakage of liquid from the canister. The pad may be pre-loaded with a flavorant.