An inhalation-synchronized fluid dispenser device having a body with a mouthpiece, a fluid reservoir containing a fluid and a propellant gas mounted to slide axially in the body, a metering valve including a valve member assembled on the reservoir, an actuator element movable and/or deformable between a non-actuation position in which the metering valve cannot be actuated, and an actuation position in which the metering valve can be actuated; and an inhalation-controlled trigger system including an inhalation-sensitive member deformable and/or movable under the effect of inhaling. The inhalation-sensitive member moves and/or deforms the actuator element from its non-actuation position towards its actuation position. The actuator element is a blocking element that, in the non-actuation position, co-operates firstly with the body and secondly with the reservoir to prevent the reservoir from moving axially in the body.

An inhalation-synchronized fluid dispenser device having a body, a reservoir containing a fluid and a propellant gas that slides axially in the body, a metering valve, a blocking element movable and/or deformable between a non-actuation position and an actuation position, and an inhalation-controlled trigger system that moves and/or deforms the blocking element from the non-actuation position towards the actuation position. The device includes an actuator fastened on the reservoir and having a proximal wall fastened on the end of the reservoir, a body that slides axially past the proximal wall, and a spring arranged between the proximal wall and a distal wall of the body, the body sliding axially past the proximal wall between a rest position and a cocked position in which the spring is compressed, such that on actuation of the trigger system, the compressed spring moves the reservoir so as to actuate the metering valve.

An inhalation-synchronized fluid dispenser device having a body (10) with a mouthpiece (400), a reservoir (100), a valve (200) assembled by a fastener element (5) on the reservoir (100). The device includes a blocking element (500) that pivots about a pivot axis B between a blocking position and an actuation position; a trigger element (600) that pivots about a pivot axis C; and an inhalation-controlled trigger system. The device includes an actuator member (800) mounted to move axially between a rest position and a primed position. A spring (850) is arranged so that when the actuator member (800) moves towards its primed position, the spring (850) is compressed, so as to transmit an axial force (F) to the reservoir (100).

An inhaler (60) has a breath actuated trigger mechanism (100) reactive to an inhalation flow to trigger the release of a substance to be inhaled. The inhaler (60) has an inspiration flow which is subject to a higher degree of flow governing post-triggering than pre-triggering. This allows the triggering flow rate to be closer to, or even higher than, the governing flow rate of the inhaler.

The invention relates to an internal seal system. The internal seal may be incorporated into a pre-filled, small-volume nebulizer assembly with a T-connector. The small-volume nebulizer may be pre-filled with at least one unit-dose of medicine and hermetically sealed until use by an input port seal and the internal seal. The internal seal may operate as a valve when the assembly is changed into a second configuration.

The invention relates to an inhalation device for powdered drugs to be received by a patient by an inhalation-caused air stream, comprising at least one powder reservoir, metering means for repeatedly metering a powder dose from the reservoir, a transportation mechanism for moving said metering means from a filling position for receiving a powder dose into an emptying position for releasing said powder dose into a powder channel, at least one activating device for manual operation by the patient, said activating device being operatively connected to said transportation mechanism such that upon operation a single powder dose is being metered, said activating device comprising a dosage key (5) acting on said transportation mechanism when pressed by the patient. The inhalation device further comprises an advancing mechanism for advancing a counter means each time the inhalation device has been activated by the patient so that a powder dose has been released into the powder channel. The counter means comprises a mechanical index coupled to a locking mechanism blocking the dosage key (5) and/or the activating device and/or the transportation mechanism after a predetermined number of metering cycles after detection of the index. Moreover, the locking mechanism includes a locking lever (7) for positive engagement with the dosage key (5) and/or the activating device and/or the transportation mechanism in the blocked condition. The inhalation device (1) is characterized in that the locking lever includes signaling means integrally formed therewith engaging the index after said predetermined number of metering cycles.

A dry powder inhaler includes an inhalation channel connected to a mouthpiece, a container for storing a powdered medicament, a de-agglomerator with a vortex chamber located at an end of the inhalation channel, a metering device including a shuttle having a dosing recess. The shuttle is movable between a filling position, in which the dosing recess is in alignment with an opening of the container, and an inhalation position, in which the dosing recess is in alignment with the vortex chamber. The opening of the container is elongated along a major axis and the dosing recess is elongated along a main axis and, when the shuttle is in the filling position, an edge of the opening of the container encloses the dosing recess.

A valved-container inhaler (150) has a mechanical return assembly with a spring (214) and a transfer (212) configured to transfer stored potential energy from the spring to a canister (51) and a clutch (208, 210) in a load path of the force between the spring and the transfer, the clutch being rotatable between a first condition in which load is transferred from the spring to the transfer, and a second condition in which the spring and the transfer can move relative to one another to interrupt the load path and thereby allow the canister to resile after actuation.

An inhaler for delivery of a medicament by inhalation includes an inhaler body for receiving a canister having a dispensing valve. A drive mechanism is provided for driving the canister from a rest position in which the valve is closed to an actuating position in which the valve is open. A resetting mechanism is provided for resetting the drive mechanism. A return mechanism is provided for returning the canister from the actuating position to the rest position, wherein the return mechanism comprises a damping system that is configured to enable the canister to automatically return from the actuating position to the rest position within a predetermined time period. A method of operation of an inhaler is also disclosed.

A breath actuated metered dose inhaler including a housing, a canister and a trigger mechanism. The trigger mechanism is activated by the inhalation of air which comprises of a diaphragm. The central rigid disk of the diaphragm is provided with the interlocking means to firmly secure and bound the peripheral flexible polymer ring with the central rigid disc. The mechanical interlock between a central rigid disk and a peripheral flexible polymer ring on the diaphragm prevent peripheral flexible polymer ring from being peeled off from the central rigid disc while the vacuum is being retained prior to inhalation.