The invention relates to a device comprising a body (10), a reservoir (100) mounted in an axially slidable manner relative to said body (10), a metering valve (200) assembled on said reservoir (100), said device comprising: a blocking element (500), a triggering element (600), a triggering system controlled by inhalation (60) cooperating with said triggering element (600), and an actuating member (800) cooperating with said blocking element (500), said device comprising an automatic valve release system which automatically returns said valve (210) of said valve (200) to its rest position after actuation of the valve regardless of the position of said actuating member (800).

A metered liquid droplet inhaling device includes a chassis; a holder releasably connected to the chassis; a container in the holder having a chamber for a composition, an opening for expelling the composition, and a piston; a dose knob accessible outside the chassis for setting a dose to be expelled by accumulating a rotational force; a power supply mechanism for converting the rotational force into an axial force applied to the piston; an activation device connected to the power supply mechanism; a mouth piece connected to the container holder and having a mouth engaging area and an air opening; a droplet generator arranged in the mouth piece and having a plurality of through passing orifices in fluid communication with the opening of the container and with the mouth piece; and a rotation damping member connected to the power supply mechanism for damping an initial pressure peak inside the container.

An inhaler is provided that includes a controller, a driver, an atomizer and one or more sensors for detecting information about a velocity of inhalation of a user of the inhaler. The controller is configured to dispense an inhalant from the inhaler during an inhalation of the user based on information about the velocity of inhalation of the user. Such information can include a duration of maximum inhalation velocity or an increase or maximum in the acceleration in inhalation velocity. Embodiments of the inhaler can be used to enhance the delivery of drugs and therapeutic agents for those patients having a weakened respiratory system who are unable to take a deep or full breadth, e.g., patients having asthma or COPD. Embodiments of the inhaler can be used to deliver a variety of drugs and therapeutic agents including agents for the treatment of asthma, diabetes, epilepsy and heart disease.

A breath-enhanced nebulizer adapted for use in administering an aerosolized pharmaceutical composition to a patient by inhalation wherein the patient is connected to a mechanical ventilator is disclosed. The nebulizer has a Venturi driven by a nebulizer air supply that draws a solution of a pharmaceutical composition into a shear zone where the solution is atomized. The Venturi effect is amplified by the internal configuration of the nebulizer to increase the rate of nebulization of drug. Optionally, breath-actuated nebulization is used, employing a pressure sensor interposed between the nebulizer and mechanical ventilator that controls the nebulizer air supply, such that nebulizer air and concomitant nebulization only occurs during the inhalation phase of a breathing cycle.

A nasal delivery device for and a method of delivering substance to a nasal airway of a subject, the nasal delivery device comprising: a mouthpiece (519) through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece (517) for fitting to a nostril of a subject, the nosepiece including a nozzle (549) through which substance is in use delivered to the nasal airway; and a manually-actuatable substance supply unit (520) for delivering substance through the nozzle of the nosepiece.

A breath actuated metered dose inhaler may comprise a canister fire system configured to fire a medicament containing canister in response to patient inhalation. The canister fire system may comprise a pneumatic force holding unit and having a rest configuration in which a metering valve of the canister is in a refill configuration; a prepared configuration in which a canister actuation force is retained by the pneumatic force holding unit and the canister fire system is actuatable by patient inhalation induced airflow; and a fire configuration in which the metering valve is in a dose delivery position. When in the prepared configuration, the force retained by the pneumatic force holding unit may be reduced by less than about 6% over a period of 5 minutes, preferably less than about 3% over a period of 5 minutes.

An inhalation-synchronized fluid dispenser device having a body with a mouthpiece, a fluid reservoir containing a fluid and a propellant gas mounted to slide axially in the body, a metering valve including a valve member assembled on the reservoir, an actuator element movable and/or deformable between a non-actuation position in which the metering valve cannot be actuated, and an actuation position in which the metering valve can be actuated; and an inhalation-controlled trigger system including an inhalation-sensitive member deformable and/or movable under the effect of inhaling. The inhalation-sensitive member moves and/or deforms the actuator element from its non-actuation position towards its actuation position. The actuator element is a blocking element that, in the non-actuation position, co-operates firstly with the body and secondly with the reservoir to prevent the reservoir from moving axially in the body.

A ventilator circuit apparatus is provided for the administration of an aerosolized drug from a nebulizer through an endotracheal tube to a patient on a mechanical ventilator with humidification of the breathing gases. Means to disconnect the nebulizer without interrupting the airflow to the patient is provided, with a T-fitting and three-way valve in the ventilator circuit that permits the nebulizer to be bypassed by the airflow, allowing the nebulizer to be removed from the apparatus without interrupting the flow of breathing gases to the patient. In embodiment, the nebulizer is breath-enhanced jet nebulizer. In an embodiment, the jet nebulizer is breath-actuated, by the use of an air pressure sensor that toggles the flow of pressurized air to the nebulizer that drives the jet required for nebulization.

A ventilator circuit apparatus is disclosed for the administration of an aerosolized drug from a nebulizer through an endotracheal tube to a patient on a mechanical ventilator with humidification of the breathing gases. In an embodiment, the nebulizer can be disconnected without interrupting the airflow to the patient. In an embodiment, a T-fitting and three-way valve in the ventilator circuit permits the nebulizer to be bypassed by the airflow, allowing the nebulizer to be removed from the apparatus without interrupting the flow of breathing gases to the patient. In an embodiment, the nebulizer is breath-enhanced jet nebulizer. In an embodiment, the jet nebulizer is breath-actuated, by use of an air pressure sensor that toggles the flow of pressurized air to the nebulizer that drives the jet required for nebulization. A related method is also disclosed.