Intranasal administration of proteins, such as insulin and insulin analogues, in particular immunogenic proteins to the upper posterior region of a nasal cavity of a subject, and in particular the olfactory bulb region.

A therapeutic device for treating one or more conditions associated with a user's nasal cavities, sinuses, and/or ear canals includes a vibration generator having an acoustic device operable to provide a sound; a seal configured to cover a nose, but not a mouth, of the user to form an air-tight chamber around the nose of the user; the vibration generator disposed in a housing connected to the seal; and a stand extending from the housing and including a ball bearing and a seat on which the ball bearing may rest, the stand including a hollow member and an orifice, the orifice disposed in the seat. The vibration generator provides the sound directly to the nose of the user. A positive pressure is created in the air-tight chamber when the user exhales, the positive pressure generating a lift force to lift the ball bearing from the seat.

A medicament delivery device is provided having an oral tubular section for placement in the mouth of a user and a nasal tubular section for placement in the naris of a user. A medicament located in a corrugated, or flexible, section joining the oral tubular section and the nasal tubular section is dispersed into the nasal cavity of the user by blowing into the oral tubular section. A pinch valve or a one way valve is used to prevent the user from accidentally inhaling the medicament. The medicament delivery device may also be used as a pulmonary delivery device into the mouth of a user.

A wearable-intranasal device for opioid overdose detection via overdose-associated increases of carbon dioxide in exhaled breath, and automatic delivery of naloxone in response. The device comprises a wearable nasal clip with drug reservoir(s) containing naloxone, and a CO.sub.2-sensitive hydrogel occluding or encapsulating the naloxone. The hydrogel transitions from a solid state to a liquid or gas state when exposed to an increase in CO.sub.2, thereby unblocking the drug reservoir(s) and releasing naloxone. The device provides a novel disposable, stimuli-responsive, naloxone delivery system, designed to trigger automatically in response to physical symptoms of an overdose without the need for bystander intervention.

A nosepiece for delivering substance to a nasal cavity of a subject, the nosepiece comprising a body part which comprises a base portion which defines a flow passage therethrough, and a projection at a distal end of the base portion which at least in part provides a tip of the nosepiece and confers a rigidity in the sagittal direction, which enables the tip to open fleshy tissue at an upper region of the nasal valve and thereby expand an open area of the nasal valve, and a flexibility in a lateral direction, orthogonal to the sagittal plane, which facilitates insertion of the tip into the nasal valve.

A nasal delivery device for and method of delivering a substance, preferably comprising oxytocin, non-peptide agonists thereof and antagonists thereof, preferably as one of a liquid, as a suspension or solution, or a powder, to the nasal airway of a subject, preferably the posterior region of the nasal airway, and preferably the upper posterior region of the nasal airway which includes the olfactory bulb and the trigeminal nerve, and preferably in the treatment of neurological conditions and disorders.

A nasal delivery device for and method of delivering particulate substance to the nasal airway of a subject, the delivery device comprising: a body assembly including a mouthpiece unit which includes a mouthpiece through which the subject in use exhales, and a substance-supply unit which is fluidly connected to the mouthpiece unit and actuatable to provide particulate substance for delivery to the nasal airway of the subject; wherein the body assembly is configured to receive a replaceable nosepiece unit which includes a nosepiece and contains a container containing particulate substance.

An exhalation delivery system for and method of treating a patient having sinus disease, comprising, following Draf 2 or Draf 3 surgery, administering a therapeutic agent including a corticosteroid to the patient, wherein the therapeutic agent is administered by an exhalation delivery device comprising a mouthpiece and a nosepiece, fitting the nosepiece to a first nostril of the patient, and the patient exhaling into the mouthpiece to create a fluid flow out of the nosepiece and into the first nostril during administration of the therapeutic agent to the patient.

A rechargeable therapeutic system for treating conditions of a user's nasal cavities, sinuses or ear canals includes a therapeutic device having a housing that includes an inlet that allows air to enter the therapeutic device. An acoustic vibrator located within the housing provides an acoustic vibration to the user, and a power supply located within the housing provides power to the acoustic vibrator. A mask is connected to the housing and configured to be applied around the nose of the user. A valve of the mask is configured to allow the user to breathe through the inlet. The mask further includes a diaphragm and a nasal cavity in which the user's nose is located when the mask is applied around the nose of the user. A recharging station is configured to provide a charging current to the power supply.

A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece for fitting to a nostril of a subject, wherein the nosepiece comprises a tip element which includes a delivery aperture from which substance is in use delivered into the nasal cavity, and the tip element is at least in part tapered such as to be inclined to a longitudinal axis of the nosepiece, with the delivery aperture extending both laterally across the tip element and along a longitudinal extent of the tip element; a nozzle through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity; and a delivery unit for delivering substance through the nozzle of the nosepiece.