A system for delivering a therapeutic agent to nasopharyngeal mucosa tissue has a shaft, a porous pad of compliant material coupled to the shaft near the distal end, and a drug reservoir. The porous pad is configured to expand from a contracted configuration to an expanded configuration. The expanded configuration is adapted to engage and conform to the mucosa tissue in a nasal cavity, and the contracted configuration has a size suitable for introduction into the nasal cavity. The drug reservoir holds a therapeutic agent and is at least partially covered by the porous pad. The drug reservoir is configured to release a fixed volume of the therapeutic agent into the porous pad within a period of less than about 120 minutes, and has a wall with a plurality of channels fluidly coupled with the porous pad.

The present disclosure provides an agent delivery device (1) for delivery of a therapeutic agent or medicinal agent to an individual. The agent delivery device (1) comprises: a frame (2) having at least one frame member (4) configured to be received and retained or accommodated within a nostril of the individual; and a delivery element (8) provided on and/or carried by the at least one frame member (4) for delivering the agent, the agent preferably being either in a liquid or semi-solid form or contained in a liquid or gel medium. The delivery element (8) is provided on and/or carried by the frame member such that, when the frame member is accommodated in a nostril, the delivery element (8) contacts or engages with an inner surface (e.g., tissue) of the nostril to deliver the agent to the individual, e.g., percutaneously. In this way, the agent delivery device (1) has a delivery element (8) provided on and/or carried by a frame member (4) received and retained or accommodated within a nostril of the individual to deliver the agent in situ there. The disclosure also provides an agent delivery kit, an agent delivery system, and associated methods.

A nasal dilator device comprises a substantially U-shaped body including a central portion arranged to span a septum of a nose when worn by a user and first and second leg members extending from the central portion in a first plane, a first cantilever rib member extending outward from the U-shaped body in a second plane and a second 5 cantilever rib member extending outward from the U-shaped body in a third plane, wherein the first and second cantilever rib members extend away from each other. The nasal dilator device further comprises a first intermediate section connecting an end of the first leg member to a proximal end of the first cantilever rib member, wherein the first intermediate section extends from the first plane to the second plane; and a second intermediate section connecting an end of the second leg member to a proximal end of the second cantilever rib member, wherein the second intermediate section extends from the first plane to the third plane and at least one projection protruding from and extending along at least a portion of a length of each of the first and second cantilever rib members.

A nasal dilator device comprises a substantially U-shaped body including a central portion arranged to span a septum of a nose when worn by a user and first and second leg members extending from the central portion in a first plane. The device further comprises a first cantilever rib member extending outward from the U-shaped body in a second plane and a second cantilever rib member extending outward from the U-shaped body in a third plane, wherein the first and second cantilever rib members extend away from each other. The device further comprises a first intermediate section connecting an end of the first leg member to a proximal end of the first cantilever rib member, wherein the first intermediate section extends between the first plane and second plane and a second intermediate section connecting an end of the second leg member to a proximal end of the second cantilever rib member, wherein the second intermediate section extends between the first plane and the third plane.

A method for delivering medicament such as for ameliorating pain in a patient includes introducing an injector through a nasal passage of the patient into a region substantially medial and/or posterior and/or inferior to a sphenopalatine ganglion (SPG) of the patient; and delivering a medicament from the injector superiorly and/or laterally and/or anteriorly towards the SPG. A device for delivering a medicament to a patient in need thereof includes (a) an injector containing a first end configured to remain outside a nasal passage of the patient and a second end configured for entry into the nasal passage of the patient; and (b) an introducer configured for engagement with a nostril of the patient and containing a passageway configured for slidably receiving the injector. The injector is moveable between a storage position preceding the engagement and an engaging position pursuant to the engagement.

A nasal insert may include a wall in the shape of a tube, the wall including a first end defining a first orifice and a second end defining a second orifice. The first end may have a diameter, diagonal measurement, or cross-sectional area larger than that of the second end. The first end may define at least one break in the wall, so that the first end incompletely encircles the first orifice. The second end may completely encircle the second orifice.

A compact single-nostril atomizer for the inhalation of active ingredients is presented. The atomizer has an elastic U-shaped housing, a first end of which can be introduced into the nostril and a second end of which is formed as a clamping element. In the first end of the housing a cavity for receiving a reservoir is disposed. A reservoir containing an active ingredient can be inserted into the cavity.

The invention relates to an assembly (1) for controlling the dispensing of a product into a nasal cavity of a user, comprising: a first holder (20) configured to be fastened to a product dispensing device (30) for nasal pathway, and comprising a first orientation sensor (21) configured to measure a data relating to the orientation of the first holder (20) in space, a second holder (10) configured to be fastened to the user's head, and comprising a second orientation sensor (11) configured to measure a data relating to the orientation of the second holder (10) in space along three reference axes, and an information processing system suitable for receiving the data measured by the first sensor (21) and the second sensor (11) and for determining an information about the orientation of the first holder (21) with respect to the second holder according to said measured data.

Embodiments disclosed herein relate to respiratory interfaces for use in treating various respiratory issues including, but not limited to, sleep disorder breathing (e.g. snoring, sleep apnea), and in other forms of assisted and unassisted respiration. Embodiments disclosed herein further relate to nasal prongs, flanges and valves for use with respiratory interfaces. Embodiments disclosed herein further relate to evaluating patient compliance with a respiratory interface and harvesting energy for the respiratory.

A device for controlling respiration during sleep based on the user physiological characteristic. The device includes an odor disperser for dispersing an odor; at least one detector for detecting a physiological characteristic of a user; and a controller for controlling respiration of the user by instructing the odor dispenser to disperse an odor responsive to detections by the at least one detector.