A respiratory device of negative pressure type comprising a shell fastened to the user's chest and/or abdomen with minimal dead space, one or more vacuum and compressed air chambers attached to the shell; vacuum generating and compressed air generating sources connected to the vacuum and compressed air chambers respectively, one or more openings on the shell to allow exchange of the air enclosed between shell and user's body, with the vacuum and compressed air chambers; a valve shuttling between the vacuum and compressed air chambers. By having low dead space, pre-generated vacuum and compressed air close to the user, and the use of fast acting valves in some embodiments, the power requirement, weight, and size are reduced, making the device low cost and portable. In some embodiments, the vacuum and compressed air generating sources can be mounted on the shell itself, making the device ambulatory.

The invention comprises a method of operating a breathing apparatus comprising measuring a baseline breath flow parameter being respiratory rate and/or tidal volume or a parameter derived therefrom, varying the flow rate provided by the breathing apparatus, measuring a current breath flow parameter being respiratory rate and/or tidal volume or a parameter derived therefrom, comparing the baseline and current breath flow parameters, and altering operation of the breathing apparatus based on the comparison. The invention also comprises a breathing apparatus that implements the above method.

A fluid delivery system provides fluid, such as supplement oxygen, to a patient in response to inhalation. The fluid delivery system includes a valve assembly that is triggered by sensing onset of inspiration by measuring a change in temperature or fluid flow of air flow in a nasal or oral cannula, mask or helmet.

A system and method for providing a therapy to a subject may include a lumen configured to be coupled to a portion of a respiration passage of the subject to receive air respired by the subject. A sensor is configured to monitor the lumen and generate a signal based on the air respired by the subject. A pressure pulse delivery system is configured to deliver a pressure pulse along the lumen to the subject and a reservoir of therapeutic agent is coupled to the lumen. A processor is configured to receive the signal from the sensor, determine, from at least the signal, an exhalation period of the subject, and based on the exhalation period, cause the pressure pulse delivery system to deliver a pressure pulse to the subject. Following the pressure pulse, the processor can cause the therapeutic agent to be delivered from the reservoir.

Some embodiments provide an electronic vapor provision system including a vaporizer for vaporizing liquid for inhalation by a user of the electronic vapor provision system; a power supply comprising a cell or battery for supplying power to the vaporizer; a sensor for detecting airflow through the electronic vapor provision system as a result of the inhalation by the user; a manual activation device; and a control unit for causing power to be supplied to the vaporizer to vaporize the liquid providing the control unit determines that both (i) the sensor is detecting airflow through the electronic vapor provision system and (ii) the manual activation device has been manually activated by the user.

A bi-level positive airway pressure device includes a housing that has a patient port for connecting to an airway of a patient. Within the housing is a device that generates a positive airway pressure directed towards to patient port. Also within the housing is a system that detects exhalation (by a patient that is connected to the patient port) that enters into the patient port. Responsive to detecting exhalation, a blocking device occludes the device that generating positive airway pressure, thereby reducing or stopping the positive airway pressure. Upon the system detects abatement of exhalation, the blocking device is operated to no longer occlude the device for generating positive airway pressure, thereby providing positive airway pressure to the patient port.

A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically-responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.

A breathable gas inlet control device permits flow regulation at the inlet of a flow generator for a respiratory treatment apparatus such as a ventilator or continuous positive airway pressure device. The device may implement a variable inlet aperture size based on flow conditions. In one embodiment, an inlet flow seal opens or closes the inlet to a blower in accordance with changes in pressure within a seal activation chamber near the seal. The seal may be formed by a flexible membrane. A controller selectively changes the pressure of the seal activation chamber by controlling a set of one or more flow control valves to selectively stop forward flow, prevent back flow or lock open the seal to permit either back flow or forward flow. The controller may set the flow control valves as a function of detected respiratory conditions based on data from pressure and/or flow sensors.

The present disclosure relates generally to the field of nicotine delivery. The disclosure teaches a nicotine meta-salicylate. More specifically, the disclosure teaches a condensation nicotine aerosol where nicotine meta-salicylate is vaporized. This disclosure relates to aerosol nicotine delivery devices. The delivery devices can be activated by actuation mechanisms to vaporize thin films comprising a nicotine meta-salicylate. More particularly, this disclosure relates to thin films of nicotine salt with meta salicylic acid for the treatment of nicotine craving and for effecting smoking cessation.

A nebulizer device has an aerosol generator mounted in a housing, and a mouthpiece. The device is adapted for delivery of an active agent in an aerosol into the buccal cavity, with droplet size greater than 10 μm. Aerosolization is started at or after the end of breath inhalation and is stopped at or before the start of breath inhalation. The flow is via mouthpiece with internal ridges which periodically narrow the flow path volume to so that droplets coalesce in the flow path before the mesh.